Viruses for the treatment of cellular proliferative disorders
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United States of America Patent
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Sep 1, 2009
Grant Date -
Jan 24, 2008
app pub date -
May 30, 2007
filing date -
Nov 12, 1999
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Abstract
Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering a immunosuppressive agent.
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