Compositions and methods for inhibiting expression of Nav1.8 gene
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United States of America Patent
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Sep 1, 2009
Grant Date -
May 10, 2007
app pub date -
Nov 3, 2006
filing date -
Nov 4, 2005
priority date (Note) -
Expired
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Abstract
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.
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