Polyketides and their synthesis
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United States of America Patent
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Sep 29, 2009
Grant Date -
Feb 5, 2004
app pub date -
Aug 14, 2001
filing date -
Aug 14, 2000
priority date (Note) -
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Abstract
Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.
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