High-throughput screening method for intergrin antagonist and new peptide screened therefrom
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United States of America Patent
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Oct 20, 2009
Grant Date -
Oct 25, 2007
app pub date -
Nov 26, 2004
filing date -
Nov 29, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.
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