Method and apparatus for analyzing particles in a fluid
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United States of America Patent
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Oct 20, 2009
Grant Date -
May 1, 2008
app pub date -
Oct 28, 2007
filing date -
Oct 30, 2006
priority date (Note) -
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Abstract
A method and apparatus for analyzing particles in a fluid, such as proteinaceous particles in a pharmaceutical formulation intended for parenteral delivery, are disclosed. The method comprises arranging a fluid to form a wide and shallow stream, acquiring a sequence of magnified still images of the stream, and processing said images, so as to highlight images of particles in the flowing fluid. The apparatus includes a light source, a flow cell, a lens with increased depth of view, a detector array, and a processor for acquiring and processing the images of particles in the fluid stream.
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