Optical sampling interface system for in-vivo measurement of tissue
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United States of America Patent
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Oct 20, 2009
Grant Date -
Sep 15, 2005
app pub date -
Dec 8, 2004
filing date -
May 2, 2000
priority date (Note) -
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status (Latency Note)
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Abstract
An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
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