Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1
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United States of America Patent
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Oct 27, 2009
Grant Date -
Nov 3, 2005
app pub date -
Apr 27, 2005
filing date -
Mar 2, 2001
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Abstract
Compounds of the formulawherein: Y′ is O or S, W′ isZ′ is selected from the group consisting ofheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
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