Methods for using OX-40 ligand to enhance an antigen specific immune response
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United States of America Patent
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Nov 24, 2009
Grant Date -
Sep 6, 2007
app pub date -
Sep 29, 2006
filing date -
Feb 24, 1998
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Abstract
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified OX-40 receptor binding agent and a pharmaceutically acceptable carrier, wherein the composition is administered to the mammal such that the OX-40 receptor binding agent is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.
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