Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE)
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United States of America Patent
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Dec 8, 2009
Grant Date -
May 9, 2002
app pub date -
Sep 19, 2001
filing date -
Sep 22, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
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