US Patent No: 7,632,521

Number of patents in Portfolio can not be more than 2000

Controlled release potassium chloride tablets

ALSO PUBLISHED AS: 20080279937, 20050013860

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Abstract

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A unit dosage form, such as a tablet for delivering potassium into the body in a controlled release fashion, comprises of a multiplicity of microencapsulated potassium chloride crystals, which are further coated with a plasticized polymer to improve compressibility of the microcapsules. The compressible microcapsules are blended with a compression aid, such as microcrystalline cellulose and a glidant, such as colloidal silicon dioxide, to form controlled release potassium chloride tablets. The tablets may optionally include other excipients such as surfactants and disintegrants. The tablets thus produced exhibit not only high crushing strength and low friability but also release potassium in humans in a desired controlled release fashion similar to commercially available potassium chloride tablets.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
APTALIS PHARMATECH, INC.VANDALIA, OH41

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kramer, Craig West Carrollton, OH 8 4
Venkatesh, Gopi Vandalia, OH 34 39

Cited Art Landscape

Patent Info (Count) # Cites Year
 
APTALIS PHARMATECH, INC. (8)
5,252,337 Controlled release calcium channel blocker microcapsules 23 1991
5,422,122 Controlled release potassium chloride tablet 11 1992
5,622,723 Procedure for encapsulating chlorpheniramine 3 1995
5,639,475 Effervescent microcapsules 47 1995
5,651,984 Controlled release potassium tablet 8 1995
5,653,993 Procedure for encapsulating ibuprofen 15 1995
5,814,332 Procedure for encapsulating ibuprofen 5 1997
6,139,865 Taste-masked microcapsule compositions and methods of manufacture 49 1997
 
Key Pharmaceuticals, Inc. (5)
4,508,702 Sustained release aspirin 11 1984
4,555,399 Aspirin tablet 38 1984
4,634,587 Sustained release quinidine dosage form 21 1984
4,587,118 Dry sustained release theophylline oral formulation 49 1984
4,863,743 Controlled release potassium chloride 16 1986
 
ALZA CORPORATION (4)
4,519,801 Osmotic device with wall comprising cellulose ether and permeability enhancer 75 1982
4,553,973 Process for preparing osmotic device 33 1985
4,915,953 Dosage form for delivering acetaminophen or phenylpropanolamine 47 1989
5,156,850 Dosage form for time-varying patterns of drug delivery 32 1990
 
ANDRX PHARMACEUTICALS, INC. (3)
5,397,574 Controlled release potassium dosage form 10 1993
5,567,441 Diltiazem controlled release formulation 78 1995
6,210,716 Controlled release bupropion formulation 24 1999
 
CIMA LABS INC. (3)
5,219,574 Magnesium carbonate and oil tableting aid and flavoring additive 31 1991
5,223,264 Pediatric effervescent dosage form 97 1991
5,178,878 Effervescent dosage form with microparticles 175 1992
 
TANABE SEIYAKU CO., LTD. (3)
4,389,331 Process for preparing pharmaceutically active compound-containing microcapsules 10 1980
4,462,982 Microcapsules and method of preparing same 43 1982
4,542,042 Process for preparing free-flowing ethylcellulose microcapsules 17 1983
 
Astra Lakemedel Aktiebolag (2)
4,994,260 Pharmaceutical mixture 28 1985
5,085,868 Liquid dosage form for all oral administration of a pharmaceutically active substance 18 1990
 
CIBA-GEIGY CORPORATION (2)
4,666,703 Storage-stable, quick-disintegrating pressed shapes containing pharmaceutical active substances 38 1985
4,954,349 Oral magnesium and potassium compositions and use 10 1989
 
ELAN CORPORATION, PLC (2)
4,898,737 Controlled absorption pharmaceutical composition 14 1988
5,505,962 Controlled release pharmaceutical formulation 19 1994
 
EURAND AMERICA, INC. (2)
5,709,886 Effervescent microcapsules 43 1997
6,451,345 Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration 11 2000
 
EURAND S.P.A. (2)
4,460,563 Process for preparing microcapsules in a liquid vehicle 89 1981
5,409,711 Pharmaceutical formulations 52 1991
 
Nortec Development Associates, Inc. (2)
4,800,087 Taste-masked pharmaceutical compositions 103 1986
5,084,278 Taste-masked pharmaceutical compositions 104 1989
 
NYCOMED DANMARK A/S (2)
4,572,833 Method for preparing a pharmaceutical controlled release composition 75 1983
4,716,041 Diffusion coated multiple-units dosage form 74 1985
 
PURDUE PHARMA L.P. (2)
5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 147 1993
6,316,031 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 23 1999
 
A/S ALFRED BENZON (1)
4,193,985 Multiple-units drug dose 63 1978
 
A/S ALFRED BENZON, HALMTORVET 29, DK-1700 COPENHAGEN V, DENMARK, A CORP OF DENMARK (1)
4,713,248 Diffusion coated multiple-units dosage form 75 1985
 
Adria Laboratories, Inc. (1)
4,316,884 Sustained release pharmaceutical formulation 30 1980
 
ALKERMES CONTROLLED THERAPEUTICS INC. II (1)
4,389,330 Microencapsulation process 278 1980
 
AMERICAN HOME PRODUCTS CORPORATION (1)
4,259,315 Controlled release potassium dosage form 38 1980
 
BENZON PHARMA, A DANISH LIMITED COMPANY (1)
4,574,080 Combination formulation 26 1983
 
BioAdvances LLC (1)
5,840,329 Pulsatile drug delivery system 146 1997
 
CAPSULE, INC. (1)
2006/0222,699 FLAVORED VEGETARIAN CELLULOSE CAPSULE AND METHODS FOR PRODUCING SAID CAPSULE. 3 2005
 
DAINIPPON PHARMACEUTICAL CO., LTD. (1)
5,082,669 Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked 29 1990
 
DRUGTECH CORPORATION (1)
5,133,974 Extended release pharmaceutical formulations 244 1990
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
5,180,587 Tablet formulations of pesticides 15 1990
 
E. R. Squibb & Sons, Inc. (1)
5,137,730 Tablet composition and method for problem pharmaceutical materials using citric acid 12 1991
 
EGIS GYOGYSZERGYAR (1)
5,192,552 Process for preparing microcapsules providing the rapid release of a drug as active ingredient 5 1989
 
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARY (1)
4,748,023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content 41 1984
 
ELAN PHARMA INTERNATIONAL LIMITED (1)
4,952,402 Controlled release powder and process for its preparation 188 1988
 
EM Diagnostic Systems, Inc. (1)
4,820,627 Method of preparing particles suitable for tabletting into diagnostic reagents 32 1986
 
ETHYPHARM (1)
5,464,632 Rapidly disintegratable multiparticular tablet 134 1994
 
EURAND INTERNATIONAL S.P.A. (1)
5,008,117 Formulation for preparing extemporaneous homogeneous microcapsule suspension 21 1988
 
FARMITALIA CARLO ERBA S.R.L. (1)
4,895,836 Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them 5 1987
 
FIRST NATIONAL BANK OF GRAPEVINE (1)
5,002,774 Sustained release pharmaceutical tablet 18 1989
 
GACELL LABORATORIES AB (1)
4,629,620 Membrane-coated sustained-release tablets and method 29 1985
 
General Foods Corporation (1)
4,182,778 Encapsulation of vitamin and mineral nutrients 22 1978
 
GLAXO WELLCOME INC. (1)
5,879,706 Valaciclovir tablets containing colloidal silicon dioxide 11 1997
 
GLAXOSMITHKLINE LLC (1)
5,578,316 Palatable pharmaceutical compositions 14 1995
 
JANSSEN PHARMACEUTICALS, INC. (1)
5,215,756 Preparation of pharmaceutical and other matrix systems by solid-state dissolution 24 1990
 
John Wyeth & Brother Limited (1)
4,524,060 Slow release pharmaceutical composition 54 1983
 
Laboratories Smith Kline & French (1)
5,229,134 Pharmaceutical compositions 16 1990
 
MAYNE PHARMA INTERNATIONAL PTY LTD (1)
5,807,579 Pseudoephedrine combination pharmaceutical compositions 43 1996
 
MCNEIL-PPC, INC. (1)
5,075,114 Taste masking and sustained release coatings for pharmaceuticals 90 1990
 
MILES INC. (1)
5,073,377 Method of preparing oral dosage forms with a granulating composition 30 1990
 
N.V. ORGANON (1)
5,238,688 Method for preparing a powdered particulate composition 5 1990
 
Norwich Eaton Pharmaceuticals, Inc. (1)
5,032,406 Dual-action tablet 44 1989
 
PFIZER INC. (1)
4,321,253 Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration 31 1980
 
Roussel Uclaf (1)
4,432,966 Compressed tablets for disintegration in the colon comprising an active ingredient containing nucleus coated with a first layer containing microcrystalline cellulose which is coated with an enteric organic polymer coating 80 1982
 
SCHERING CORPORATION (1)
5,073,374 Fast dissolving buccal tablet 66 1988
 
Sterling Drug Inc. (1)
4,302,440 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof 38 1980
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 105 1990
 
The Procter & Gamble Company (1)
4,971,791 Taste masking compositions 12 1990
 
WATSON PHARMACEUTICALS, INC. (1)
4,832,955 Controlled release potassium chloride composition 7 1988
 
Other [Check patent profile for assignment information] (2)
4,777,044 Therapeutic preparation having ammonium nitrate as its active substance 1 1987
2008/0207,673 Method for Treating Cancer, Coronary, Inflammatory and Macular Disease, Combining the Modulation of Zinc-and/or Copper Dependent Proteins 2 2006

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