US Patent No: 7,632,521

Number of patents in Portfolio can not be more than 2000

Controlled release potassium chloride tablets

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ALSO PUBLISHED AS: 20080279937, 20050013860
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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A unit dosage form, such as a tablet for delivering potassium into the body in a controlled release fashion, comprises of a multiplicity of microencapsulated potassium chloride crystals, which are further coated with a plasticized polymer to improve compressibility of the microcapsules. The compressible microcapsules are blended with a compression aid, such as microcrystalline cellulose and a glidant, such as colloidal silicon dioxide, to form controlled release potassium chloride tablets. The tablets may optionally include other excipients such as surfactants and disintegrants. The tablets thus produced exhibit not only high crushing strength and low friability but also release potassium in humans in a desired controlled release fashion similar to commercially available potassium chloride tablets.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
APTALIS PHARMATECH, INC.VANDALIA, OH37

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kramer, Craig West Carrollton, OH 7 4
Venkatesh, Gopi Vandalia, OH 28 34

Cited Art Landscape

Patent Info (Count) # Cites Year
 
APTALIS PHARMATECH, INC. (8)
5,252,337 Controlled release calcium channel blocker microcapsules 22 1991
5,422,122 Controlled release potassium chloride tablet 11 1992
5,622,723 Procedure for encapsulating chlorpheniramine 3 1995
5,639,475 Effervescent microcapsules 44 1995
5,651,984 Controlled release potassium tablet 8 1995
5,653,993 Procedure for encapsulating ibuprofen 11 1995
5,814,332 Procedure for encapsulating ibuprofen 5 1997
6,139,865 Taste-masked microcapsule compositions and methods of manufacture 44 1997
 
Key Pharmaceuticals, Inc. (5)
4,508,702 Sustained release aspirin 11 1984
4,555,399 Aspirin tablet 38 1984
4,634,587 Sustained release quinidine dosage form 21 1984
4,587,118 Dry sustained release theophylline oral formulation 46 1984
4,863,743 Controlled release potassium chloride 16 1986
 
ALZA CORPORATION (4)
4,519,801 Osmotic device with wall comprising cellulose ether and permeability enhancer 71 1982
4,553,973 Process for preparing osmotic device 32 1985
4,915,953 Dosage form for delivering acetaminophen or phenylpropanolamine 44 1989
5,156,850 Dosage form for time-varying patterns of drug delivery 31 1990
 
ANDRX PHARMACEUTICALS, INC. (3)
5,397,574 Controlled release potassium dosage form 10 1993
5,567,441 Diltiazem controlled release formulation 69 1995
6,210,716 Controlled release bupropion formulation 21 1999
 
CIMA LABS INC. (3)
5,219,574 Magnesium carbonate and oil tableting aid and flavoring additive 31 1991
5,223,264 Pediatric effervescent dosage form 86 1991
5,178,878 Effervescent dosage form with microparticles 161 1992
 
TANABE SEIYAKU CO., LTD. (3)
4,389,331 Process for preparing pharmaceutically active compound-containing microcapsules 10 1980
4,462,982 Microcapsules and method of preparing same 43 1982
4,542,042 Process for preparing free-flowing ethylcellulose microcapsules 16 1983
 
Astra Lakemedel Aktiebolag (2)
4,994,260 Pharmaceutical mixture 25 1985
5,085,868 Liquid dosage form for all oral administration of a pharmaceutically active substance 17 1990
 
CIBA-GEIGY CORPORATION (2)
4,666,703 Storage-stable, quick-disintegrating pressed shapes containing pharmaceutical active substances 38 1985
4,954,349 Oral magnesium and potassium compositions and use 10 1989
 
ELAN CORPORATION, PLC (2)
4,898,737 Controlled absorption pharmaceutical composition 13 1988
5,505,962 Controlled release pharmaceutical formulation 17 1994
 
EURAND AMERICA, INC. (2)
5,709,886 Effervescent microcapsules 42 1997
6,451,345 Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration 11 2000
 
EURAND S.P.A. (2)
4,460,563 Process for preparing microcapsules in a liquid vehicle 89 1981
5,409,711 Pharmaceutical formulations 49 1991
 
Nortec Development Associates, Inc. (2)
4,800,087 Taste-masked pharmaceutical compositions 100 1986
5,084,278 Taste-masked pharmaceutical compositions 100 1989
 
NYCOMED DANMARK A/S (2)
4,572,833 Method for preparing a pharmaceutical controlled release composition 75 1983
4,716,041 Diffusion coated multiple-units dosage form 73 1985
 
PURDUE PHARMA L.P. (2)
5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 132 1993
6,316,031 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 20 1999
 
A/S ALFRED BENZON (1)
4,193,985 Multiple-units drug dose 62 1978
 
A/S ALFRED BENZON, HALMTORVET 29, DK-1700 COPENHAGEN V, DENMARK, A CORP OF DENMARK (1)
4,713,248 Diffusion coated multiple-units dosage form 72 1985
 
Adria Laboratories, Inc. (1)
4,316,884 Sustained release pharmaceutical formulation 30 1980
 
ALKERMES CONTROLLED THERAPEUTICS INC. II (1)
4,389,330 Microencapsulation process 273 1980
 
AMERICAN HOME PRODUCTS CORPORATION (1)
4,259,315 Controlled release potassium dosage form 38 1980
 
BENZON PHARMA, A DANISH LIMITED COMPANY (1)
4,574,080 Combination formulation 26 1983
 
BioAdvances LLC (1)
5,840,329 Pulsatile drug delivery system 135 1997
 
CAPSULE, INC. (1)
2006/0222,699 FLAVORED VEGETARIAN CELLULOSE CAPSULE AND METHODS FOR PRODUCING SAID CAPSULE. 3 2005
 
DAINIPPON PHARMACEUTICAL CO., LTD. (1)
5,082,669 Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked 28 1990
 
DRUGTECH CORPORATION (1)
5,133,974 Extended release pharmaceutical formulations 231 1990
 
E. I. DU PONT DE NEMOURS AND COMPANY (1)
5,180,587 Tablet formulations of pesticides 15 1990
 
E. R. Squibb & Sons, Inc. (1)
5,137,730 Tablet composition and method for problem pharmaceutical materials using citric acid 12 1991
 
EGIS GYOGYSZERGYAR (1)
5,192,552 Process for preparing microcapsules providing the rapid release of a drug as active ingredient 5 1989
 
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARY (1)
4,748,023 Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content 39 1984
 
ELAN PHARMA INTERNATIONAL LIMITED (1)
4,952,402 Controlled release powder and process for its preparation 177 1988
 
EM Diagnostic Systems, Inc. (1)
4,820,627 Method of preparing particles suitable for tabletting into diagnostic reagents 30 1986
 
ETHYPHARM (1)
5,464,632 Rapidly disintegratable multiparticular tablet 124 1994
 
EURAND INTERNATIONAL S.P.A. (1)
5,008,117 Formulation for preparing extemporaneous homogeneous microcapsule suspension 21 1988
 
FARMITALIA CARLO ERBA S.P.A. (1)
4,895,836 Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them 5 1987
 
FIRST NATIONAL BANK OF GRAPEVINE (1)
5,002,774 Sustained release pharmaceutical tablet 17 1989
 
GACELL LABORATORIES AB (1)
4,629,620 Membrane-coated sustained-release tablets and method 29 1985
 
General Foods Corporation (1)
4,182,778 Encapsulation of vitamin and mineral nutrients 22 1978
 
GLAXO WELLCOME INC. (1)
5,879,706 Valaciclovir tablets containing colloidal silicon dioxide 11 1997
 
GLAXOSMITHKLINE LLC (1)
5,578,316 Palatable pharmaceutical compositions 14 1995
 
JANSSEN PHARMACEUTICA INC. (1)
5,215,756 Preparation of pharmaceutical and other matrix systems by solid-state dissolution 24 1990
 
John Wyeth & Brother Limited (1)
4,524,060 Slow release pharmaceutical composition 54 1983
 
Laboratories Smith Kline & French (1)
5,229,134 Pharmaceutical compositions 14 1990
 
MAYNE PHARMA INTERNATIONAL PTY LTD (1)
5,807,579 Pseudoephedrine combination pharmaceutical compositions 42 1996
 
MCNEIL-PPC, INC. (1)
5,075,114 Taste masking and sustained release coatings for pharmaceuticals 81 1990
 
MILES INC. (1)
5,073,377 Method of preparing oral dosage forms with a granulating composition 29 1990
 
N.V. ORGANON (1)
5,238,688 Method for preparing a powdered particulate composition 5 1990
 
Norwich Eaton Pharmaceuticals, Inc. (1)
5,032,406 Dual-action tablet 44 1989
 
PFIZER INC. (1)
4,321,253 Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration 29 1980
 
Roussel Uclaf (1)
4,432,966 Compressed tablets for disintegration in the colon comprising an active ingredient containing nucleus coated with a first layer containing microcrystalline cellulose which is coated with an enteric organic polymer coating 79 1982
 
SCHERING CORPORATION (1)
5,073,374 Fast dissolving buccal tablet 58 1988
 
Sterling Drug Inc. (1)
4,302,440 Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof 37 1980
 
TCF BANK SAVINGS FSB N/K/A TCF NATIONAL BANK (1)
5,126,145 Controlled release tablet containing water soluble medicament 103 1990
 
The Procter & Gamble Company (1)
4,971,791 Taste masking compositions 12 1990
 
WATSON PHARMACEUTICALS, INC. (1)
4,832,955 Controlled release potassium chloride composition 7 1988
 
Other [Check patent profile for assignment information] (2)
4,777,044 Therapeutic preparation having ammonium nitrate as its active substance 1 1987
2008/0207,673 Method for Treating Cancer, Coronary, Inflammatory and Macular Disease, Combining the Modulation of Zinc-and/or Copper Dependent Proteins 2 2006

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