High performance liquid chromatography with an aqueous mobile phase for analysis of drug and its metabolite
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United States of America Patent
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Dec 15, 2009
Grant Date -
Oct 12, 2006
app pub date -
Mar 4, 2004
filing date -
Mar 4, 2003
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Abstract
The amount of drug consumption caused by a specific drug-metabolizing enzyme and/or the amount of the resulting metabolite(s) is measured by chromatography with an aqueous mobile phase under temperature control using a packing material whose surface is coated with a polymer having a hydration force varying in the temperature range of 0° C. to 80° C. This system enables proper evaluation of drug-metabolizing capacity through simple means without adversely affecting the environment.
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