Fully human antibodies directed against the human insulin-like growth factor-1 receptor
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United States of America Patent
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Dec 29, 2009
Grant Date -
Jan 31, 2008
app pub date -
May 3, 2004
filing date -
May 1, 2003
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Abstract
This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific antibodes, or fusion proteins), and to uses of the antibodies and derivatives in therapeutic, and diagnostic methods. The invention relates to nucleic acids encoding the anti-IGF-IR, methods of generating the antibodies and expression. The invention further relates to combination therapies using ant-IGF-IR antibodies with anti-neoplastic drugs.
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