US Patent No: 7,642,074

Number of patents in Portfolio can not be more than 2000

PUFA polyketide synthase systems and uses thereof

ALSO PUBLISHED AS: 20070256146

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Abstract

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The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
DSM IP ASSETS B.V.6411 TE HEERLEN968

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barclay, William R Boulder, CO 160 2706
Flatt, James H Longmont, CO 77 1523
Metz, James G Longmont, CO 139 2297
Weaver, Craig A Boulder, CO 90 1427

Cited Art Landscape

Patent Info (Count) # Cites Year
 
DSM IP ASSETS B.V. (38)
5,130,242 Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids 232 1990
5,908,622 Food product containing thraustochytrium and/or schizochytrium microflora and an additional agricultural based ingredient 71 1997
6,566,583 Schizochytrium PKS genes 72 1999
7,001,772 Product and process for transformation of Thraustochytriales microorganisms 66 2002
7,247,461 Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof 36 2002
7,214,853 Schizochytrium PKS genes 50 2002
7,211,418 PUFA polyketide synthase systems and uses thereof 61 2004
7,217,856 PUFA polyketide synthase systems and uses thereof 60 2004
7,256,022 Pufa polyketide synthase systems and uses thereof 48 2005
7,256,023 PUFA polyketide synthase systems and uses thereof 49 2005
7,259,295 PUFA polyketide synthase systems and uses thereof 48 2005
7,271,315 PUFA polyketide synthase systems and uses thereof 60 2006
2007/0244,192 PLANT SEED OILS CONTAINING POLYUNSATURATED FATTY ACIDS 61 2007
2007/0270,494 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 57 2007
2008/0026,434 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0026,435 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0026,438 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0026,439 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0026,440 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
2008/0032,351 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
2008/0038,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0022,422 CHIMERIC PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 57 2007
2008/0148,433 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0038,791 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0038,792 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 36 2007
2008/0044,867 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
2008/0038,793 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0038,794 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0038,795 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0038,796 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0038,797 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0040,822 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0044,868 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0044,869 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 42 2007
2008/0044,871 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0044,872 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0044,873 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
2008/0050,790 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 41 2007
 
Sagami Chemical Research Center (3)
5,246,841 Microbial process for production of eicosapentaenoic acid 66 1991
5,683,898 Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid 73 1995
5,798,259 Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid 61 1996
 
ABBOTT LABORATORIES (2)
6,677,145 Elongase genes and uses thereof 59 2001
7,208,590 Genes involved in polyketide synthase pathways and uses thereof 21 2003
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
2004/0172,682 Production of very long chain polyunsaturated fatty acids in oilseed plants 63 2004
7,125,672 Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts 66 2004
 
MARTEK BIOSCIENCES CORPORATION (2)
2008/0038,378 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 37 2007
2008/0038,379 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 46 2007
 
MONSANTO COMPANY (2)
5,639,790 Plant medium-chain thioesterases 97 1993
6,140,486 Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants 93 1998
 
BIORIGINAL FOOD & SCIENCE CORP. (1)
7,087,432 Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof 54 2001
 
BIOTICA TECHNOLOGY LIMITED (1)
6,033,883 Production of polyketides in bacteria and yeast 78 1997
 
IACR-ROTHAMSTED (1)
2005/0089,865 Delta 6 desaturases from primulaceae, expressing plants and pufa-containing oils 61 2004
 
KOSAN BIOSCIENCES, INC. (1)
2004/0005,672 Heterologous production of polyketides 53 2003
 
Miami University, an Ohio corporation (1)
2004/0139,498 Fatty acid elongase 3-ketoacyl CoA synthase polypeptides 46 2004
 
ROCHE DIAGNOSTICS GMBH (1)
6,503,706 Method for identifying human and animal cells having an unlimited proliferation of tumor-formation potential 49 1996
 
SEMBIOSYS GENETICS INC. (1)
2007/0245,431 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 63 2007
 
SUPERMEDIA LLC (1)
2008/0044,870 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 43 2007
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
5,672,491 Recombinant production of novel polyketides 169 1994
 
THE UNIVERSITY OF YORK (1)
2005/0164,192 Transgenic plants expressing enzymes involved in fatty acid biosynthesis 122 2005
 
WASHINGTON STATE UNIVERSITY (1)
2004/0010,817 Plant acyl-CoA synthetases 46 2003
 
Other [Check patent profile for assignment information] (1)
5,310,242 Portable infant seat 58 1992
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
DSM IP ASSETS B.V. (2)
8,309,796 Chimeric PUFA polyketide synthase systems and uses thereof 0 2011
8,859,855 Chimeric PUFA polyketide synthase systems and uses thereof 0 2012
* Cited By Examiner

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