Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
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United States of America Patent
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Jan 5, 2010
Grant Date -
Aug 11, 2005
app pub date -
Dec 17, 2004
filing date -
Nov 6, 1997
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Abstract
This invention provides a method for preparing, in high purity and high yield, heterobifunctional derivatives of poly(ethylene glycol) or related polymers. A chromatographic purification step is not necessary in the method. In accordance with the method of the invention, an intermediate polymer having a formula of W-Poly-OH is provided bearing a removable group W at one terminus. The intermediate polymer W-Poly-OH is first altered by modifying the OH group to a first functional group X, followed by the removal of W to generate a second hydroxyl group. The latter hydroxyl group may then be further converted to a second functional group Y, thus providing the desired heterobifunctional derivative.
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