Opioid delivery system
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United States of America Patent
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Jan 19, 2010
Grant Date -
Apr 21, 2005
app pub date -
Aug 27, 2004
filing date -
Feb 28, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An opioid formulation for pulmonary administration in the treatment or management of pain, a pulmonary drug delivery device containing, method of administering, kit containing, and uses of same. The formulation contains at least one rapid-onset opioid and preferably also contains a sustained-effect opioid to reduce the frequency of administration. The invention employs the side effects of the opioid formulation to permit patients to self-limit drug intake, thereby avoiding toxicity while achieving analgesia. A pharmacokinetic and pharmacodynamic model is employed to determine optimum drug formulations and optimum parameters for administration.
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