39-desmethoxy derivatives of rapamycin
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United States of America Patent
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Jan 19, 2010
Grant Date -
Aug 7, 2008
app pub date -
Mar 10, 2006
filing date -
Mar 11, 2005
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Abstract
The present invention relates to novel 39-desmethoxyrapamycin derivatives, methods for their production, and uses thereof. In a further aspect the present invention provides for the use of these 39-desmethoxyrapamycin derivatives in the treatment of cancer and/or B-cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation, vascular disease and fibrotic diseases, the stimulation of neuronal regeneration or the treatment of fungal infections.
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