US Patent No: 7,651,682

Number of patents in Portfolio can not be more than 2000

Polymerizable emulsions for tissue engineering

ALSO PUBLISHED AS: 20050112186

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Importance

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Abstract

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Provided are biocompatible viscoelastic solid materials derived from polymerization of fluid water-in-oil emulsions, along with methods of their preparation and methods for their use for tissue engineering applications, including for reforming diseased, damaged or degenerated intervertebral discs by acceptably non-invasive means.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
GENTIS, INC.PHILADELPHIA, PA3

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cohen, Charles Fair Lawn, NJ 22 194
Devore, David Nyack, NY 31 103
Ducheyne, Paul Rosemont, PA 49 1582

Cited Art Landscape

Patent Info (Count) # Cites Year
 
HOWMEDICA OSTEONICS CORP. (5)
5,047,055 Hydrogel intervertebral disc nucleus 616 1990
5,192,326 Hydrogel bead intervertebral disc nucleus 517 1991
6,187,048 Intervertebral disc implant 241 1997
6,414,086 Compositions, processes and methods of improving the wear resistance of prosthetic medical devices 26 2000
6,436,137 Compositions, processes and methods of improving the wear resistance of prosthetic medical devices 24 2001
 
3M INNOVATIVE PROPERTIES COMPANY (4)
6,444,725 Color-changing dental compositions 52 2000
6,528,555 Adhesive for use in the oral environment having color-changing capabilities 62 2000
6,623,664 Conductive adhesive and biomedical electrode 5 2002
6,890,963 High internal phase emulsion foams containing polyelectrolytes 7 2004
 
ANOVA CORP. (4)
6,719,797 Nucleus augmentation with in situ formed hydrogels 102 2000
6,685,695 Method and apparatus for providing nutrition to intervertebral disc tissue 72 2002
6,648,920 Natural and synthetic supplements to engineered annulus and disc tissues 65 2002
6,755,863 Rotator cuff repair using engineered tissues 12 2002
 
CORIUM INTERNATIONAL, INC. (3)
2003/0130,427 Two-phase, water-absorbent bioadhesive composition 16 2002
2003/0170,308 Hydrogel compositions 71 2002
6,803,420 Two-phase, water-absorbent bioadhesive composition 72 2002
 
ORTHO DEVELOPMENT CORPORATION (3)
6,852,127 Method of implanting an intervertebral spacer 16 2002
D493225 Implant 34 2003
D501555 Implant 31 2003
 
PAUL ROYALTY FUND, L.P. (3)
5,914,356 Bioactive load bearing bone bonding compositions 76 1998
6,800,245 Sterile polymerizable systems and kits and methods of their manufacture and use 15 2000
6,987,136 Bioactive spinal implant material and method of manufacture thereof 28 2002
 
AXIOMED SPINE CORPORATION (2)
6,607,558 Artificial disc 136 2001
2003/0208,271 Artificial disc 83 2003
 
CORNELL UNIVERSITY (2)
6,716,445 Hydrogel entrapping therapeutic agent and stent with coating comprising this 12 2002
6,709,668 Hydrogel-forming system with hydrophobic and hydrophilic components 19 2003
 
DISC DYNAMICS, INC. (2)
5,888,220 Articulating joint repair 305 1996
6,224,630 Implantable tissue repair device 381 1998
 
HERON THERAPEUTICS, INC. (2)
5,145,675 Two step method for preparation of controlled release formulations 60 1991
7,220,414 Degradable polyacetal polymers 9 2001
 
INCEPT LLC (2)
6,514,534 Methods for forming regional tissue adherent barriers and drug delivery systems 91 1998
7,025,990 Methods for forming regional tissue adherent barriers and drug delivery systems 25 2002
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
6,471,993 Three-dimensional polymer matrices 84 2000
7,097,855 Transdermal thermal polymerization 4 2000
 
RAY MEDICA, INC. (2)
4,772,287 Prosthetic disc and method of implanting 695 1987
4,904,260 Prosthetic disc containing therapeutic material 567 1988
 
ReGen Corporation (2)
5,108,438 Prosthetic intervertebral disc 257 1990
5,258,043 Method for making a prosthetic intervertebral disc 216 1991
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (2)
6,103,255 Porous polymer scaffolds for tissue engineering 93 1999
6,337,198 Porous polymer scaffolds for tissue engineering 30 2000
 
The Procter & Gamble Company (2)
5,500,451 Use of polyglycerol aliphatic ether emulsifiers in making high internal phase emulsions that can be polymerized to provide absorbent foams 43 1995
5,753,359 Foam materials for insulation, derived from high internal phase emulsions 18 1996
 
ASAHI KOGAKU KOGYO KABUSHIKI KAISHA (1)
4,702,997 Photopolymerizable laminate 14 1986
 
BEISANG, AUTHUR A., III (1)
5,258,028 Textured micro implants 128 1991
 
BIOMET 3I, LLC (1)
5,204,106 Process for restoring an osseous defect or deficiency by filling with osseous tissue 125 1990
 
CIBA SPECIALTY CHEMICALS CORPORATION (1)
5,723,512 Dimeric bisacylphosphines, oxides and sulfides 16 1996
 
DEPUY ACROMED, INC. (1)
7,294,617 Method for nonsurgical treatment of the intervertebral disc and kit therefor 3 2004
 
DEPUY SPINE, INC. (1)
6,812,211 Method for nonsurgical treatment of the intervertebral disc and kit therefor 42 2002
 
DSM IP ASSETS B.V. (1)
6,298,189 Radiation-curable optical glass fiber coating compositions, coated optical glass fibers, and optical glass fiber assemblies 21 1998
 
EASTMAN CHEMICAL COMPANY (1)
6,462,109 Surfactantless latex compositions and methods of making polymer blends using these compositions 8 2000
 
Endospine, Ltd. (1)
6,428,576 System for repairing inter-vertebral discs 199 2000
 
ESPE STIFTUNG & CO. (1)
5,008,303 Molding composition for making casting patterns 3 1990
 
HUNTSMAN ADVANCED MATERIALS AMERICAS INC. (1)
6,045,972 Coating method using aqueous photopolymerizable compositions 5 1999
 
IMPERIAL CHEMICAL INDUSTRIES PLC (1)
5,151,217 Micro-emulsions 30 1991
 
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (1)
6,436,426 Process for producing porous polymer materials 11 2001
 
INTRINSIC THERAPEUTICS, INC. (1)
6,482,235 Devices and methods of vertebral disc augmentation 221 2000
 
IS PHARMACEUTICALS LIMITED (1)
7,083,806 Wound gels 13 2001
 
KANSAI PAINT CO., LTD. (1)
4,408,028 Oxidation-curable emulsion composition containing a cellulose derivative 9 1980
 
KERAPLAST TECHNOLOGIES, LTD. (1)
6,849,092 Implantable prosthetic or tissue expanding device 16 2001
 
KIMBERLY-CLARK WORLDWIDE, INC. (1)
2003/0232,088 Materials with both bioadhesive and biodegradable components 5 2002
 
L'OREAL (1)
2003/0235,548 Cosmetic composition for care and/or treatment and/or makeup of the emulsion type structured with silicone polymers 30 2002
 
LOCTITE CORPORATION (1)
6,231,714 Allylic phenyl ether (meth)acrylate compositions and novel allylic phenyl ether (meth)acrylate monomers 8 1998
 
MICROVENTION, INC. (1)
6,878,384 Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use 20 2001
 
Minnesota Mining and Manufacturing Company (1)
5,405,618 Biomosaic polymer obtained by emulsion polymerization of hydrophobic monomers in the presence of bioactive materials 20 1992
 
RAYMEDICA, LLC (1)
5,674,295 Prosthetic spinal disc nucleus 533 1996
 
SPINE WAVE, INC. (1)
6,423,333 Sealing or filling tissue defects using polyfunctional crosslinking agents and protein polymers 42 1999
 
STRYKER TECHNOLOGIES CORPORATION (1)
5,681,872 Bioactive load bearing bone graft compositions 78 1995
 
SYNTHES USA, LLC (1)
2004/0220,296 Thermogelling polymer blends for biomaterial applications 42 2004
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
2007/0005,140 Fabrication and use of biocompatible materials for treating and repairing herniated spinal discs 15 2006
 
The Glidden Company (1)
4,522,961 Aqueous self-curing polymeric blends 26 1984
 
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (1)
6,224,893 Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering 82 1997
 
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (1)
5,964,807 Compositions and methods for intervertebral disc reformation 109 1996
 
UNIVERSITAT ZURICH (1)
2003/0044,468 Two-phase processing of thermosensitive polymers for use as biomaterials 17 2002
 
UNIVERSITY OF CONNECTICUT (1)
6,497,729 Implant coating for control of tissue/implant interactions 173 1999
 
UNIVERSITY OF MASSACHUSETTS (1)
6,773,713 Injection molding of living tissues 31 2002
 
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (1)
6,143,293 Assembled scaffolds for three dimensional cell culturing and tissue generation 99 1998
 
UNIVERSITY OF SOUTHERN CALIFORNIA (1)
6,228,900 Crosslinking of polyethylene for low wear using radiation and thermal treatments 161 1999
 
VERSITECH LIMITED (1)
6,593,394 Bioactive and osteoporotic bone cement 30 2000
 
VIA SPECIAL PURPOSE CORPORATION (1)
7,238,203 Bioactive spinal implants and method of manufacture thereof 111 2002
 
WARSAW ORTHOPEDIC, INC. (1)
6,620,196 Intervertebral disc nucleus implants and methods 172 2000
 
WILLIAM MARSH RICE UNIVERSITY (1)
2005/0158,358 Tissue engineering scaffolds promoting matrix protein production 4 2004
 
Other [Check patent profile for assignment information] (2)
6,376,742 In vivo tissue engineering with biodegradable polymers 36 2000
2001/0038,831 Super-absorbent hydrogel foams 21 2001

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
DEPUY MITEK, LLC (3)
8,524,662 Compositions and methods for treating joints 0 2010
8,455,436 Compositions and methods for treating joints 0 2010
8,623,839 Compositions and methods for stabilized polysaccharide formulations 0 2011
 
DEPUY MITEK, INC. (1)
8,398,611 Compositions and methods for treating joints 2 2010

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