Stable liquid IL-1 antagonist formulations

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United States of America Patent

PATENT NO 7655758
APP PUB NO 20080188817A1
SERIAL NO

12048717

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Formulations of an interleukin-1 (IL-1) antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the IL-1 antagonist is an IL-1 trap composed of a dimer of two fusion proteins having an amino acid sequence of SEQ ID NO: 10. Stable liquid formulations made with and without sodium chloride, and made with phosphate or histidine buffer, are provided.

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bowers, Katherine Clayton, US 3 9
Dix, Daniel Langrangeville, US 36 1358
Goolcharran, Chimanlall Hopewell Junction, US 6 70
Lin, Leu-Fen H White Plains, US 12 178

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