Non-homogeneous systems for the resolution of enantiomeric mixtures
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United States of America Patent
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Feb 9, 2010
Grant Date -
Jan 4, 2007
app pub date -
Dec 27, 2005
filing date -
Oct 9, 1998
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Abstract
The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogenous reaction system.
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