ErbB4 receptor-specific neuregulin related ligands and uses therefor

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United States of America Patent

PATENT NO 7662585
SERIAL NO

10944116

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Abstract

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The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.

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Patent Owner(s)

Patent OwnerAddress
GENENTECH INCSOUTH SAN FRANCISCO CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Godowski, Paul J Burlingame, US 1845 7409
Mark, Melanie Rose Burlingame, US 11 48
Zhang, Dong-Xiao Burlingame, US 12 68

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