Modified carbocyanine dyes and their conjugates
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United States of America Patent
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Mar 2, 2010
Grant Date -
Aug 2, 2007
app pub date -
Feb 14, 2007
filing date -
Sep 29, 2000
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Abstract
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
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