Methods and compositions for blood pool identification, drug distribution quantification and drug release verification
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United States of America Patent
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Mar 2, 2010
Grant Date -
May 27, 2004
app pub date -
Sep 11, 2003
filing date -
Sep 11, 2002
priority date (Note) -
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Abstract
Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
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