Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
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United States of America Patent
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Apr 20, 2010
Grant Date -
Jul 12, 2007
app pub date -
Dec 23, 2004
filing date -
Dec 23, 2003
priority date (Note) -
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Abstract
The present invention is related to 10,20-di-O ester derivatives of camptothecin and pharmaceutical formulations thereof. The compounds and pharmaceutical formulations of the present invention possess increased biological life span and bioavailability and reduced toxicity, while maintaining anti-cancer activity.
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