Reversible inhibition of pyramidal gap junction activity
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United States of America Patent
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Apr 27, 2010
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May 3, 2007
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May 5, 2006
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Abstract
The present invention relates to a novel method of inhibiting gap junction-mediated signaling in pyramid cells. Pyramidal gap junctions are quickly and reversibly inhibited by beta-amyloid or biologically active fragments thereof. The present invention also relates to the use of beta-amyloid as an anticonvulsant for the treatment of epilepsy and other pathological hypersynchrony conditions in humans and non-human animals.
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