US Patent No: 7,713,297

Number of patents in Portfolio can not be more than 2000

Drug-releasing stent with ceramic-containing layer

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ALSO PUBLISHED AS: 20040039438
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Abstract

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A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen at the site of the implant. The sidewall of the open-ended tubular structure of the stent is a base layer of a metal biologically compatible with blood and tissue of the human body. An intermediate metal particle layer of substantial greater radiopacity overlies the base layer, with particles bonded to the base layer and to each other to leave interstices therebetween as a repository for retaining and dispensing drugs or other agents for time release therefrom after the stent is implanted, to assist the stent in maintaining the lumen open. The particles are composed primarily of a noble metal—an alloy of platinum-iridium. The sidewall has holes extending therethrough, and the particle layer resides along the outward facing and inward facing surfaces, and the edges of the through holes and open ends of the sidewall. The larger particles are bonded to surfaces of the sidewall and progressively smaller particles are bonded to those and to each other up to the outer portion of the particle layer. Exposed surfaces of the particle layer are coated with ceramic-like iridium oxide or titanium nitrate, as a biocompatible material to inhibit irritation of tissue at the inner lining of the vessel when the stent is implanted. One or more anti-thrombotic, anti-platelet, anti-inflammatory and/or anti-proliferative drugs are retained in the interstices, together with a biodegradable carrier for time release therefrom. In an alternative embodiment, the intermediate layer is solid and the biodegradable carrier and drugs or agents therein are applied to the surface of the ceramic-like coating. Gene transfer is alternatively used to control tissue proliferation.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4726

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alt, Eckhard Ottobrunn, DE 132 5756

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5,439,446 Stent and therapeutic delivery system 248 1994
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MEDTRONIC, INC. (5)
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5,624,411 Intravascular stent and method 502 1995
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (3)
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SCIMED LIFE SYSTEMS, INC. (3)
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AMS MEDINVENT S.A. (2)
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5,061,275 Self-expanding prosthesis 617 1989
 
CORDIS CORPORATION (2)
4,994,071 Bifurcating stent apparatus and method 905 1989
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LIFESHIELD SCIENCES LLC (2)
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MED INSTITUTE, INC. (2)
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BOSTON SCIENTIFIC CORPORATION (1)
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BRIDGE BLOOD TECHNOLOGIES LLC, NEW YORK LIMITED LIABILITY COMPANY (1)
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COCHLEAR LIMITED (1)
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COOK INCORPORATED (1)
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DAI NIPPON PRINTING CO., LTD. (1)
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DUKE UNIVERSITY (1)
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Lathrotec, Inc. (1)
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MEDINOL LTD. (1)
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MEDTRONIC AVE, INC. (1)
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Quanam Medical Corporation (1)
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RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
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SHIRKHANZADEH, MORTEZA (1)
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SMITH & NEPHEW RICHARDS INC. (1)
5,649,951 Zirconium oxide and zirconium nitride coated stents 122 1995
 
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UNIVERSITY OF UTAH (1)
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WORLD HEART CORPORATION (1)
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Other [Check patent profile for assignment information] (5)
5,236,413 Method and apparatus for inducing the permeation of medication into internal tissue 235 1990
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Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
BOSTON SCIENTIFIC SCIMED, INC. (36)
8,089,029 Bioabsorbable metal medical device and method of manufacture 1 2006
8,187,620 Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents 1 2006
8,048,150 Endoprosthesis having a fiber meshwork disposed thereon 1 2006
8,067,054 Stents with ceramic drug reservoir layer and methods of making and using the same 2 2007
7,976,915 Endoprosthesis with select ceramic morphology 1 2007
8,002,823 Endoprosthesis coating 1 2007
7,942,926 Endoprosthesis coating 1 2007
7,931,683 Articles having ceramic coated surfaces 12 2007
8,052,743 Endoprosthesis with three-dimensional disintegration control 0 2007
8,353,949 Medical devices with drug-eluting coating 1 2007
8,052,744 Medical devices and methods of making the same 1 2007
8,052,745 Endoprosthesis 0 2007
8,002,821 Bioerodible metallic ENDOPROSTHESES 3 2007
8,128,689 Bioerodible endoprosthesis with biostable inorganic layers 1 2007
8,057,534 Bioerodible endoprostheses and methods of making the same 5 2007
7,955,382 Endoprosthesis with adjustable surface features 7 2007
7,981,150 Endoprosthesis with coatings 4 2007
8,216,632 Endoprosthesis coating 0 2007
8,029,554 Stent with embedded material 2 2007
7,938,855 Deformable underlayer for stent 2 2007
8,080,055 Bioerodible endoprostheses and methods of making the same 0 2007
8,431,149 Coated medical devices for abluminal drug delivery 0 2008
8,070,797 Medical device with a porous surface for delivery of a therapeutic agent 2 2008
7,998,192 Endoprostheses 1 2008
8,236,046 Bioerodible endoprosthesis 0 2008
8,221,822 Medical device coating by laser cladding 0 2008
7,985,252 Bioerodible endoprosthesis 1 2008
8,382,824 Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides 0 2008
8,071,156 Endoprostheses 1 2009
8,287,937 Endoprosthese 1 2009
8,449,603 Endoprosthesis coating 1 2009
8,231,980 Medical implants including iridium oxide 0 2009
8,267,992 Self-buffering medical implants 0 2010
8,066,763 Drug-releasing stent with ceramic-containing layer 0 2010
8,574,615 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 0 2010
8,668,732 Surface treated bioerodible metal endoprostheses 0 2011
 
REMON MEDICAL TECHNOLOGIES LTD. (1)
8,303,643 Method and device for electrochemical formation of therapeutic species in vivo 0 2010

Maintenance Fees

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