US Patent No: 7,713,297

Number of patents in Portfolio can not be more than 2000

Drug-releasing stent with ceramic-containing layer

ALSO PUBLISHED AS: 20040039438

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen at the site of the implant. The sidewall of the open-ended tubular structure of the stent is a base layer of a metal biologically compatible with blood and tissue of the human body. An intermediate metal particle layer of substantial greater radiopacity overlies the base layer, with particles bonded to the base layer and to each other to leave interstices therebetween as a repository for retaining and dispensing drugs or other agents for time release therefrom after the stent is implanted, to assist the stent in maintaining the lumen open. The particles are composed primarily of a noble metal—an alloy of platinum-iridium. The sidewall has holes extending therethrough, and the particle layer resides along the outward facing and inward facing surfaces, and the edges of the through holes and open ends of the sidewall. The larger particles are bonded to surfaces of the sidewall and progressively smaller particles are bonded to those and to each other up to the outer portion of the particle layer. Exposed surfaces of the particle layer are coated with ceramic-like iridium oxide or titanium nitrate, as a biocompatible material to inhibit irritation of tissue at the inner lining of the vessel when the stent is implanted. One or more anti-thrombotic, anti-platelet, anti-inflammatory and/or anti-proliferative drugs are retained in the interstices, together with a biodegradable carrier for time release therefrom. In an alternative embodiment, the intermediate layer is solid and the biodegradable carrier and drugs or agents therein are applied to the surface of the ceramic-like coating. Gene transfer is alternatively used to control tissue proliferation.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4586

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alt, Eckhard Ottobrunn, DE 134 6524

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
5,236,413 Method and apparatus for inducing the permeation of medication into internal tissue 263 1990
5,147,370 Nitinol stent for hollow body conduits 511 1991
5,348,553 Method for promoting blood vessel healing 72 1991
5,383,935 Prosthetic implant with self-generated current for early fixation in skeletal bone 76 1993
5,690,670 Stents of enhanced biocompatibility and hemocompatibility 144 1995
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (3)
5,605,696 Drug loaded polymeric material and method of manufacture 641 1995
* 6,174,329 Protective coating for a stent with intermediate radiopaque coating 205 1996
* 5,843,172 Porous medicated stent 394 1997
 
LATHAM, DANIEL W. (1)
5,464,650 Intravascular stent and method 807 1993
 
Shepherd Patents S.A. (1)
4,954,126 Prosthesis comprising an expansible or contractile tubular body 736 1989
 
GENE-TRAK SYSTEMS CORPORATION (1)
5,073,365 Clinical and personal care articles enhanced by lubricants and adjuvants 86 1989
 
TDK CORPORATION (1)
5,125,971 Living hard tissue replacement, its preparation 91 1990
 
SCIMED LIFE SYSTEMS, INC. (3)
5,464,450 Biodegradable drug delivery vascular stent 288 1994
5,551,954 Biodegradable drug delivery vascular stent 295 1994
5,500,013 Biodegradable drug delivery vascular stent 341 1995
 
MEDINOL LTD. (1)
5,449,373 Articulated stent 706 1994
 
MEDTRONIC, INC. (5)
4,886,062 Intravascular radially expandable stent and method of implant 1333 1987
5,607,463 Intravascular medical device 319 1993
5,443,496 Intravascular radially expandable stent 419 1993
5,591,224 Bioelastomeric stent 266 1994
5,624,411 Intravascular stent and method 544 1995
 
DAI NIPPON PRINTING CO., LTD. (1)
5,679,440 Optical card 53 1995
 
COOK INCORPORATED (1)
4,800,882 Endovascular stent and delivery system 1288 1987
 
Quanam Medical Corporation (1)
5,674,242 Endoprosthetic device with therapeutic compound 406 1996
 
WORLD HEART CORPORATION (1)
4,665,896 Power supply for body implant and method of use 143 1985
 
MEDTRONIC AVE, INC. (1)
5,290,585 Lubricious hydrogel coatings 134 1992
 
ULVAC JAPAN, LTD., (1)
4,401,546 Ferromagnetic high speed sputtering apparatus 64 1982
 
SHIRKHANZADEH, MORTEZA (1)
5,205,921 Method for depositing bioactive coatings on conductive substrates 114 1991
 
BRIDGE BLOOD TECHNOLOGIES LLC, NEW YORK LIMITED LIABILITY COMPANY (1)
5,322,520 Iontophoretic structure for medical devices 191 1992
 
ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH (1)
5,405,367 Structure and method of manufacture of an implantable microstimulator 342 1993
 
TINI ALLOY COMPANY (1)
5,061,914 Shape-memory alloy micro-actuator 330 1989
 
SCICO TEC GMBH (1)
5,102,403 Therapeutic medical instrument for insertion into body 164 1990
 
INTERNATIONAL BUSINESS MACHINES CORPORATION (1)
5,693,928 Method for producing a diffusion barrier and polymeric article having a diffusion barrier 50 1996
 
CORDIS CORPORATION (2)
* 4,994,071 Bifurcating stent apparatus and method 961 1989
5,163,958 Carbon coated tubular endoprosthesis 408 1991
 
INTEGRATED DEVICE TECHNOLOGY, INC. (1)
5,672,242 High selectivity nitride to oxide etch process 46 1996
 
SPINAL CORD SOCIETY A MN CORPORATION (1)
5,314,453 Position sensitive power transfer antenna 203 1991
 
PETER RICHTER (1)
5,302,414 Gas-dynamic spraying method for applying a coating 255 1992
 
The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (1)
4,308,868 Implantable electrical device 81 1980
 
STENT TECH, INC. (1)
5,858,556 Multilayer composite tubular structure and method of making 277 1997
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (1)
4,585,652 Electrochemical controlled release drug delivery system 190 1984
 
INTERMEDICAT GMBH, GERLISWILSTRASSE 74, CH-6020 EMMENBRUCKE, SWITZERLAND, (1)
4,784,659 Vessel and prosthesis impregnated with diisocyanate crosslinked gelatin 95 1987
 
SPIRE CORPORATION (1)
* 5,474,797 Bactericidal coatings for implants 99 1994
 
Travenol Laboratories (Israel) Ltd. (1)
4,976,692 Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus 123 1989
 
DUKE UNIVERSITY (1)
5,527,337 Bioabsorbable stent and method of making the same 414 1994
 
EXPANDABLE GRAFTS PARTNERSHIP, 8000 I.H. 10 WEST, STE. 1265, SAN ANTONIO, TX A GENERAL PARTNERSHIP OF TX. (1)
4,733,665 Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft 2295 1985
 
AMS MEDINVENT S.A. (2)
4,655,771 Prosthesis comprising an expansible or contractile tubular body 1386 1983
5,061,275 Self-expanding prosthesis 660 1989
 
TECHNICAL SERVICES AND MARKETING, INC. (1)
5,603,556 Rail car load sensor 62 1995
 
The Kendall Company (1)
4,705,502 Suprapubic catheter with dual balloons 126 1986
 
COCHLEAR LIMITED (1)
5,279,292 Charging system for implantable hearing aids and tinnitus maskers 228 1992
 
MED INSTITUTE, INC. (2)
5,609,629 Coated implantable medical device 687 1995
5,873,904 Silver implantable medical device 790 1997
 
The United States of America as represented by the Secretary of the Navy (1)
5,380,298 Medical device with infection preventing feature 77 1993
 
UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (1)
5,091,205 Hydrophilic lubricious coatings 332 1989
 
BOSTON SCIENTIFIC SCIMED, INC. (10)
5,195,969 Co-extruded medical balloons and catheter using such balloons 297 1991
5,270,086 Multilayer extrusion of angioplasty balloons 407 1991
5,304,121 Drug delivery system making use of a hydrogel polymer coating 534 1991
5,366,504 Tubular medical prosthesis 462 1992
5,674,192 Drug delivery 226 1993
5,397,307 Drug delivery PTCA catheter and method for drug delivery 167 1993
5,449,382 Minimally invasive bioactivated endoprosthesis for vessel repair 388 1994
5,439,446 Stent and therapeutic delivery system 286 1994
5,578,075 Minimally invasive bioactivated endoprosthesis for vessel repair 265 1995
5,824,077 Clad composite stent 144 1995
 
LIFESHIELD SCIENCES LLC (2)
4,657,544 Cardiovascular graft and method of forming same 106 1984
5,693,085 Stent with collagen 512 1995
 
SMITH & NEPHEW RICHARDS INC. (1)
5,649,951 Zirconium oxide and zirconium nitride coated stents 140 1995
 
BOSTON SCIENTIFIC CORPORATION (1)
5,843,089 Stent lining 178 1996
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
5,587,507 Synthesis of tyrosine derived diphenol monomers 112 1995
 
Lathrotec, Inc. (1)
5,120,322 Method and apparatus for treatment of fibrotic lesions 169 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
REMON MEDICAL TECHNOLOGIES LTD. (1)
8,303,643 Method and device for electrochemical formation of therapeutic species in vivo 0 2010
 
BOSTON SCIENTIFIC SCIMED, INC. (46)
8,840,660 Bioerodible endoprostheses and methods of making the same 0 2006
8,089,029 Bioabsorbable metal medical device and method of manufacture 1 2006
8,187,620 Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents 1 2006
8,048,150 Endoprosthesis having a fiber meshwork disposed thereon 3 2006
8,815,275 Coatings for medical devices comprising a therapeutic agent and a metallic material 0 2006
8,067,054 Stents with ceramic drug reservoir layer and methods of making and using the same 2 2007
7,976,915 Endoprosthesis with select ceramic morphology 1 2007
8,771,343 Medical devices with selective titanium oxide coatings 0 2007
8,002,823 Endoprosthesis coating 2 2007
7,942,926 Endoprosthesis coating 1 2007
8,815,273 Drug eluting medical devices having porous layers 0 2007
7,931,683 Articles having ceramic coated surfaces 19 2007
8,052,743 Endoprosthesis with three-dimensional disintegration control 2 2007
8,353,949 Medical devices with drug-eluting coating 2 2007
8,052,744 Medical devices and methods of making the same 2 2007
8,052,745 Endoprosthesis 0 2007
8,002,821 Bioerodible metallic ENDOPROSTHESES 3 2007
8,808,726 Bioerodible endoprostheses and methods of making the same 0 2007
* 8,128,689 Bioerodible endoprosthesis with biostable inorganic layers 1 2007
8,057,534 Bioerodible endoprostheses and methods of making the same 6 2007
* 7,955,382 Endoprosthesis with adjustable surface features 14 2007
* 7,981,150 Endoprosthesis with coatings 8 2007
8,216,632 Endoprosthesis coating 0 2007
8,029,554 Stent with embedded material 4 2007
7,938,855 Deformable underlayer for stent 2 2007
8,080,055 Bioerodible endoprostheses and methods of making the same 1 2007
8,431,149 Coated medical devices for abluminal drug delivery 2 2008
8,070,797 Medical device with a porous surface for delivery of a therapeutic agent 4 2008
7,998,192 Endoprostheses 3 2008
8,236,046 Bioerodible endoprosthesis 1 2008
8,221,822 Medical device coating by laser cladding 0 2008
7,985,252 Bioerodible endoprosthesis 4 2008
8,382,824 Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides 0 2008
8,071,156 Endoprostheses 1 2009
8,920,491 Medical devices having a coating of inorganic material 0 2009
8,932,346 Medical devices having inorganic particle layers 0 2009
8,287,937 Endoprosthese 1 2009
* 8,449,603 Endoprosthesis coating 3 2009
* 2009/0319,032 ENDOPROSTHESIS COATING 22 2009
8,900,292 Coating for medical device having increased surface area 0 2009
8,231,980 Medical implants including iridium oxide 0 2009
8,267,992 Self-buffering medical implants 1 2010
8,066,763 Drug-releasing stent with ceramic-containing layer 2 2010
8,574,615 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 1 2010
8,668,732 Surface treated bioerodible metal endoprostheses 0 2011
8,715,339 Bioerodible endoprostheses and methods of making the same 1 2011
 
STERLING VASCULAR SYSTEMS, INC. (1)
* 2011/0172,763 Matrix Coated Stent 0 2009
* Cited By Examiner

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Nov 11, 2017
11.5 Year Payment $7400.00 $3700.00 $1850.00 Nov 11, 2021
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00