US Patent No: 7,713,297

Number of patents in Portfolio can not be more than 2000

Drug-releasing stent with ceramic-containing layer

ALSO PUBLISHED AS: 20040039438

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Abstract

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A vascular or endoluminal stent is adapted to be implanted in a vessel, duct or tract of a human body to maintain an open lumen at the site of the implant. The sidewall of the open-ended tubular structure of the stent is a base layer of a metal biologically compatible with blood and tissue of the human body. An intermediate metal particle layer of substantial greater radiopacity overlies the base layer, with particles bonded to the base layer and to each other to leave interstices therebetween as a repository for retaining and dispensing drugs or other agents for time release therefrom after the stent is implanted, to assist the stent in maintaining the lumen open. The particles are composed primarily of a noble metal—an alloy of platinum-iridium. The sidewall has holes extending therethrough, and the particle layer resides along the outward facing and inward facing surfaces, and the edges of the through holes and open ends of the sidewall. The larger particles are bonded to surfaces of the sidewall and progressively smaller particles are bonded to those and to each other up to the outer portion of the particle layer. Exposed surfaces of the particle layer are coated with ceramic-like iridium oxide or titanium nitrate, as a biocompatible material to inhibit irritation of tissue at the inner lining of the vessel when the stent is implanted. One or more anti-thrombotic, anti-platelet, anti-inflammatory and/or anti-proliferative drugs are retained in the interstices, together with a biodegradable carrier for time release therefrom. In an alternative embodiment, the intermediate layer is solid and the biodegradable carrier and drugs or agents therein are applied to the surface of the ceramic-like coating. Gene transfer is alternatively used to control tissue proliferation.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOSTON SCIENTIFIC SCIMED, INC.MAPLE GROVE, MN4606

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alt, Eckhard Ottobrunn, DE 113 6469

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
REMON MEDICAL TECHNOLOGIES LTD. (1)
8,303,643 Method and device for electrochemical formation of therapeutic species in vivo 0 2010
 
BOSTON SCIENTIFIC SCIMED, INC. (47)
8,840,660 Bioerodible endoprostheses and methods of making the same 1 2006
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8,067,054 Stents with ceramic drug reservoir layer and methods of making and using the same 2 2007
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8,771,343 Medical devices with selective titanium oxide coatings 0 2007
8,002,823 Endoprosthesis coating 2 2007
7,942,926 Endoprosthesis coating 2 2007
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8,353,949 Medical devices with drug-eluting coating 2 2007
8,052,744 Medical devices and methods of making the same 3 2007
8,052,745 Endoprosthesis 0 2007
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* 7,981,150 Endoprosthesis with coatings 8 2007
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7,985,252 Bioerodible endoprosthesis 5 2008
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8,920,491 Medical devices having a coating of inorganic material 0 2009
8,932,346 Medical devices having inorganic particle layers 0 2009
8,287,937 Endoprosthese 1 2009
* 8,449,603 Endoprosthesis coating 4 2009
* 2009/0319,032 ENDOPROSTHESIS COATING 23 2009
* 2011/0022,162 ENDOPROSTHESES 0 2009
8,900,292 Coating for medical device having increased surface area 0 2009
8,231,980 Medical implants including iridium oxide 0 2009
8,267,992 Self-buffering medical implants 5 2010
8,066,763 Drug-releasing stent with ceramic-containing layer 2 2010
8,574,615 Medical devices having nanoporous coatings for controlled therapeutic agent delivery 1 2010
8,668,732 Surface treated bioerodible metal endoprostheses 0 2011
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STERLING VASCULAR SYSTEMS, INC. (1)
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* Cited By Examiner

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7.5 Year Payment $3600.00 $1800.00 $900.00 Nov 11, 2017
11.5 Year Payment $7400.00 $3700.00 $1850.00 Nov 11, 2021
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Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
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