Process for preparing quaternary acid and ammonium salts
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United States of America Patent
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May 11, 2010
Grant Date -
Nov 6, 2008
app pub date -
Apr 28, 2008
filing date -
Oct 28, 2005
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Abstract
A process for preparing a quaternary ammonium salt of a fibric acid, represented by the following reaction scheme:is carried out in a single operation starting from a phenol of formula (I), an α-halogenated ester of formula (II) and a quaternary ammonium hydroxide of formula (III). This process makes it possible economically to prepare a choline salt of fenofibric acid in high purity that can be used directly as the active substance in a pharmaceutical composition intended for human consumption.
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