Delivery of bioactive substances to target cells
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United States of America Patent
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May 25, 2010
Grant Date -
Dec 8, 2005
app pub date -
Jun 18, 2004
filing date -
Jun 18, 2003
priority date (Note) -
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Abstract
A system for introducing a bioactive substance into a target cell within a body. The bioactive substance is transported to the target cell using a superparamagnetic nanoparticle and a controllable magnetic field generator that is capable of moving the nanoparticle to the target cell through the body in three dimensions. The nanoparticle may be covered with a biocompatible shell that forms a covalent bond with the bioactive substance. In an alternative embodiment, the bioactive substance and a plurality of nanoparticles are supported by a bioerodable matrix that forms a nanosphere. The nanosphere may be moved into the target cell using an external magnetic field that is controllable to move the nanosphere in three dimensions through the body and the bioactive substance is released from the nanosphere once inside the target cell.
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