Methods for detection of genetic disorders
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United States of America Patent
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Jun 1, 2010
Grant Date -
Jun 8, 2006
app pub date -
Aug 26, 2005
filing date -
May 8, 2002
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Abstract
The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present invention also provides a non-invasive method for the detection of chromosomal abnormalities in a fetus. The invention is especially useful as a non-invasive method for determining the sequence of fetal DNA. The invention further provides methods of isolation of free DNA from a sample.
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