Potent, selective and non toxic c-kit inhibitors
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United States of America Patent
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Jun 1, 2010
Grant Date -
Jul 27, 2006
app pub date -
Jun 28, 2002
filing date -
Jun 29, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to a screening method allowing the identification and selection of compounds targeting the transphosphorylase (also called phosphotransferase) domain of c-kit, more particularly compounds selected to be potent inhibitors of constitutively activated c-kit, while being unable to inhibit other activation pathways as for example the pathways leading to death of IL-3 dependent cells cultured in presence of IL-3.
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