US Patent No: 7,729,771

Number of patents in Portfolio can not be more than 2000

Nerve stimulation and blocking for treatment of gastrointestinal disorders

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
ENTEROMEDICS INC.ST PAUL, MN39

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conrad, Timothy R Eden Prairie, US 94 3863
Knudson, Mark B Shoreview, US 141 9813
Tweden, Katherine S Mahtomedi, US 65 3136
Wilson, Richard R Arden Hills, US 56 2143

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (4)
4,776,349 Tubular device for the treatment of hollow organs with electric current 159 1986
5,292,344 Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port 221 1992
2004/0036,377 HIGH VOLTAGE LC ELECTRIC AND MAGNETIC FIELD MOTIVATOR 21 2001
2006/0229,685 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 15 2006
 
UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (1)
6,243,607 Gastro-intestinal electrical pacemaker 147 1999
 
Advanced Neuromodulation Systems, Inc. (2)
2003/0181,958 Electric modulation of sympathetic nervous system 190 2002
2006/0190,053 Neural stimulation for treatment of metabolic syndrome and type 2 diabetes 42 2006
 
HITACHI GLOBAL STORAGE TECHNOLOGIES JAPAN, LTD. (1)
6,111,715 Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents 28 1998
 
MEDERI THERAPEUTICS, INC. (1)
6,405,732 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 291 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,826,428 Gastrointestinal electrical stimulation 201 2002
 
NDI MEDICAL, LLC (1)
2006/0030,919 Devices, systems, and methods employing a molded nerve cuff electrode 66 2005
 
NEUROTRONIC LTEE 11251 RUE NOTRE-DAME EST, MONTREAL, QUEBEC, CANADA H1B 2W2 (1)
4,541,432 Electric nerve stimulator device 201 1982
 
Kosan Biosciences, Inc. (1)
2002/0094,962 Motilide compounds 27 2001
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 232 2002
 
INNERCOOL THERAPIES, INC. (1)
6,364,899 Heat pipe nerve cooler 109 1999
 
VENTURE LENDING & LEASING, INC. A CORP. OF CALIFORNIA (1)
5,370,675 Medical probe device and method 884 1993
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (3)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 308 2001
2003/0045,909 Selective nerve fiber stimulation for treating heart conditions 301 2002
* 2004/0243,182 Treatment of disorders by unidirectional nerve stimulation 173 2004
 
PACESETTER, INC. (1)
5,749,907 System and method for identifying and displaying medical data which violate programmable alarm conditions 457 1997
 
UNIVERSITY OF VIRGINIA (1)
5,690,691 Gastro-intestinal pacemaker having phased multi-point stimulation 431 1996
 
ENDOVX, INC. (3)
2004/0181,178 Methods and apparatus for treatment of obesity 42 2003
2005/0203,501 Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes 58 2005
2006/0015,151 Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures 61 2005
 
LEPTOS BIODMEDICAL, INC. (1)
2003/0181,959 Wireless electric modulation of sympathetic nervous system 85 2002
 
CENTER FOR INNOVATIVE TECHNOLOGY, THE (1)
5,716,385 Crural diaphragm pacemaker and method for treating esophageal reflux disease 103 1996
 
KNIGHT, MARTHA (1)
5,620,955 Bombesin receptor antagonists and uses thereof 35 1993
 
INTRAPACE, INC. (1)
7,054,690 Gastrointestinal stimulation device 97 2003
 
SOLSTICE NEUROSCIENCES, LLC (1)
6,290,961 Method for treating dystonia with botulinum toxin type B 45 2000
 
Cerebral Stimulation, Inc. (1)
5,514,175 Auricular electrical stimulator 146 1994
 
EMORY UNIVERSITY (2)
7,072,720 Devices and methods for vagus nerve stimulation 144 2002
7,142,910 Methods of indirectly stimulating the vagus nerve with an electrical field 74 2004
 
PALO ALTO INVESTORS (1)
2005/0143,378 Treatment of conditions through pharmacological modulation of the autonomic nervous system 26 2003
 
CIT GROUP/BUSINESS CREDIT, INC. (3)
4,702,254 Neurocybernetic prosthesis 441 1985
4,867,164 Neurocybernetic prosthesis 409 1987
5,025,807 Neurocybernetic prosthesis 368 1989
 
Michael J. Jaro (1)
5,836,994 Method and apparatus for electrical stimulation of the gastrointestinal tract 271 1997
 
ALLERGAN, INC. (5)
5,437,291 Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction 240 1993
6,312,708 Botulinum toxin implant 186 2000
6,261,572 Method for treating a pancreatic disorder with a neurotoxin 54 2000
2001/0012,828 Intraspinal botulinum toxin for treating pain 27 2001
2004/0086,531 Methods for treating ulcers and gastroesophageal reflux disease 57 2002
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
5,830,434 Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide 26 1997
 
TECHNOLOGIES INTERNATIONAL INC., UNIVERSITY (1)
6,449,511 Gastrointestinal electrical stimulator having a variable electrical stimulus 125 2000
 
MEDTRONIC TRANSNEURONIX, INC. (1)
6,895,278 Gastric stimulator apparatus and method for use 105 1999
 
CYBERONICS, INC. (16)
5,188,104 Treatment of eating disorders by nerve stimulation 505 1991
5,269,303 Treatment of dementia by nerve stimulation 408 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 473 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 564 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 705 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 512 1991
5,330,515 Treatment of pain by vagal afferent stimulation 421 1992
5,263,480 Treatment of eating disorders by nerve stimulation 463 1992
5,571,150 Treatment of patients in coma by nerve stimulation 402 1994
5,540,730 Treatment of motility disorders by nerve stimulation 583 1995
5,707,400 Treating refractory hypertension by nerve stimulation 603 1995
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 327 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 407 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 273 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 188 2001
2007/0027,484 Autonomic nerve stimulation to treat a pancreatic disorder 60 2005
 
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (1)
2002/0055,779 NEURAL PROSTHESIS 147 1997
 
SECOND SIGHT MEDICAL PRODUCTS, INC. (1)
2003/0195,601 High-density array of micro-machined electrodes for neural stimulation 47 2002
 
EURO-CELTIQUE S.A. (1)
5,747,060 Prolonged local anesthesia with colchicine 145 1996
 
NIDUS MEDICAL, LLC (1)
6,746,474 Apparatus and methods for cooling a region within the body 91 2002
 
Vidamed, Inc. (1)
6,129,726 Medical probe device and method 107 1999
 
MEDTRONIC, INC. (24)
5,344,438 Cuff electrode 151 1993
5,861,014 Method and apparatus for sensing a stimulating gastrointestinal tract on-demand 255 1997
6,216,039 Method and apparatus for treating irregular gastric rhythms 102 1997
5,919,216 System and method for enhancement of glucose production by stimulation of pancreatic beta cells 176 1997
6,093,167 System for pancreatic stimulation and glucose measurement 217 1997
5,967,977 Transesophageal medical lead 77 1997
6,091,992 Method and apparatus for electrical stimulation of the gastrointestinal tract 181 1997
6,104,955 Method and apparatus for electrical stimulation of the gastrointestinal tract 167 1997
6,083,249 Apparatus for sensing and stimulating gastrointestinal tract on-demand 249 1998
5,995,872 Method and apparatus for electrical stimulation of the gastrointestinal tract 221 1998
6,097,984 System and method of stimulation for treating gastro-esophageal reflux disease 193 1998
6,135,978 System for pancreatic stimulation and glucose measurement 374 1999
6,308,105 Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms 80 1999
6,238,423 Apparatus and method for treating chronic constipation 141 1999
6,418,346 Apparatus and method for remote therapy and diagnosis in medical devices via interface systems 317 1999
6,612,983 Pancreatic secretion response to stimulation test protocol 101 2000
6,853,862 Gastroelectric stimulation for influencing pancreatic secretions 132 2000
6,261,280 Method of obtaining a measure of blood glucose 111 2000
6,532,388 Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure 232 2000
6,928,320 Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated 202 2001
2004/0193,229 Gastric electrical stimulation for treatment of gastro-esophageal reflux disease 67 2003
2004/0236,381 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 66 2003
2004/0236,382 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof 65 2003
2005/0075,693 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device 56 2004
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (6)
6,611,715 Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator 180 2001
2003/0212,440 Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system 195 2002
7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders 94 2004
2005/0137,644 Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders 95 2005
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 207 2005
2005/0149,146 Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator 130 2005
 
FLINT HILLS SCIENTIFIC, LLC (1)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 483 1999
 
NEUROPACE, INC. (1)
6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 214 2000
 
JPMORGAN CHASE BANK, N.A. (2)
2002/0062,071 Manual and automatic probe calibration 14 2001
2002/0062,071 Manual and automatic probe calibration 14 2001
 
METACURE LIMITED (2)
6,571,127 Method of increasing the motility of a GI tract 259 2000
6,993,391 Acute and chronic electrical signal therapy for obesity 46 2003
 
THD SPA (1)
6,098,629 Submucosal esophageal bulking device 192 1999
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (1)
6,610,713 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 304 2001
 
TRANSNEURONIX, INC. (2)
5,423,872 Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient 329 1993
2002/0072,780 Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity 120 2001
 
CEDARS-SINAI MEDICAL CENTER (1)
6,558,708 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia 72 2000
 
Biotronik Mess-und Therapiegeraete GmbH & Co. (1)
6,292,703 Neural electrode arrangement 130 1999
 
DEERE & COMPANY (1)
2004/0110,551 UNLOADER TUBE CLEANING SYSTEM FOR HARVESTING APPARATUS 4 2002
 
Inamed Development Company (1)
5,226,429 Laparoscopic gastric band and method 434 1991
 
CARDIOCOMMAND, INC. (1)
6,148,222 Esophageal catheters and method of use 116 1998
 
CVRX, INC. (1)
2004/0254,616 Stimulus regimens for cardiovascular reflex control 161 2004
 
SEPRACOR INC. (1)
6,369,079 Methods for treating irritable bowel syndrome using optically pure (+) norcisapride 27 2000
 
EnteroMedics Inc. (17)
2004/0172,084 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 72 2003
7,489,969 Vagal down-regulation obesity treatment 32 2003
2004/0172,085 Nerve stimulation and conduction block therapy 131 2003
2004/0172,086 Nerve conduction block treatment 76 2003
2004/0176,812 Enteric rhythm management 144 2003
7,167,750 Obesity treatment with electrically induced vagal down regulation 197 2004
2005/0070,970 Movement disorder stimulation with neural block 78 2004
2005/0070,974 Obesity and eating disorder stimulation treatment with neural block 91 2004
2005/0038,484 Controlled vagal blockage therapy 154 2004
2005/0131,485 High frequency vagal blockage therapy 144 2005
2007/0043,400 Neural electrode treatment 31 2005
2007/0135,846 Vagal obesity treatment 43 2007
2007/0135,856 Bulimia treatment 35 2007
2007/0135,857 GI inflammatory disease treatment 34 2007
2007/0135,858 Pancreatitis treatment 33 2007
2007/0142,870 Irritable bowel syndrome treatment 34 2007
2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 60 2007
 
FORSCHUNGSZENTRUM JULICH GMBH (1)
2006/0212,089 Device for the desynchronization of neuronal brain activity 35 2004
 
Active Protective Technologies, Inc. (3)
2005/0067,816 Method and apparatus for body impact protection 14 2004
2005/0067,816 Method and apparatus for body impact protection 14 2004
2005/0067,816 Method and apparatus for body impact protection 14 2004
 
CASE WESTERN RESERVE UNIVERSITY (1)
5,199,430 Micturitional assist device 127 1991
 
BIOENTERIES CORPORATION (1)
5,601,604 Universal gastric band 283 1993
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (8)
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 11 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 11 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 11 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 11 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 11 2001
6,832,114 Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes 234 2001
* 7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 210 2002
2006/0036,293 Methods for treating gastrointestinal disorders 85 2005
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
EnteroMedics Inc. (14)
7,844,338 High frequency obesity treatment 28 2004
* 2005/0038,484 Controlled vagal blockage therapy 154 2004
7,986,995 Bulimia treatment 11 2007
* 2007/0135,856 Bulimia treatment 35 2007
8,103,349 Neural electrode treatment 15 2009
8,010,204 Nerve blocking for treatment of gastrointestinal disorders 9 2010
8,046,085 Controlled vagal blockage therapy 19 2010
8,825,164 Neural modulation devices and methods 0 2011
8,369,952 Bulimia treatment 4 2011
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 1 2011
8,538,533 Controlled vagal blockage therapy 0 2011
8,862,233 Electrode band system and methods of using the system to treat obesity 0 2013
9,174,040 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2013
9,162,062 Controlled vagal blockage therapy 0 2013
 
ENDOSTIM, INC. (6)
8,831,729 Systems and methods for treating gastroesophageal reflux disease 0 2012
9,020,597 Device and implantation system for electrical stimulation of biological systems 0 2012
9,037,245 Endoscopic lead implantation method 0 2012
8,798,753 Device and implantation system for electrical stimulation of biological systems 0 2013
9,061,147 Device and implantation system for electrical stimulation of biological systems 0 2014
* 2015/0057,718 Device and Implantation System for Electrical Stimulation of Biological Systems 0 2014
 
Medibotics LLC (2)
9,067,070 Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type 0 2013
9,011,365 Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food 0 2013
* Cited By Examiner

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Dec 1, 2017
11.5 Year Payment $7400.00 $3700.00 $1850.00 Dec 1, 2021
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00