
US Patent No: 7,729,771
Number of patents in Portfolio can not be more than 2000
Nerve stimulation and blocking for treatment of gastrointestinal disorders
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Jun 1, 2010
Issued date -
Aug 13, 2007
filing date -
11/891,770
serial no -
In Force
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Abstract
At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,344,438 Cuff electrode | 83 | 1993 | |
| 5,861,014 Method and apparatus for sensing a stimulating gastrointestinal tract on-demand | 182 | 1997 | |
| 6,216,039 Method and apparatus for treating irregular gastric rhythms | 74 | 1997 | |
| 5,919,216 System and method for enhancement of glucose production by stimulation of pancreatic beta cells | 117 | 1997 | |
| 6,093,167 System for pancreatic stimulation and glucose measurement | 120 | 1997 | |
| 5,967,977 Transesophageal medical lead | 62 | 1997 | |
| 6,091,992 Method and apparatus for electrical stimulation of the gastrointestinal tract | 111 | 1997 | |
| 6,104,955 Method and apparatus for electrical stimulation of the gastrointestinal tract | 124 | 1997 | |
| 6,083,249 Apparatus for sensing and stimulating gastrointestinal tract on-demand | 143 | 1998 | |
| 5,995,872 Method and apparatus for electrical stimulation of the gastrointestinal tract | 145 | 1998 | |
| 6,097,984 System and method of stimulation for treating gastro-esophageal reflux disease | 132 | 1998 | |
| 6,135,978 System for pancreatic stimulation and glucose measurement | 220 | 1999 | |
| 6,308,105 Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms | 46 | 1999 | |
| 6,238,423 Apparatus and method for treating chronic constipation | 82 | 1999 | |
| 6,418,346 Apparatus and method for remote therapy and diagnosis in medical devices via interface systems | 171 | 1999 | |
| 6,612,983 Pancreatic secretion response to stimulation test protocol | 72 | 2000 | |
| 6,853,862 Gastroelectric stimulation for influencing pancreatic secretions | 86 | 2000 | |
| 6,261,280 Method of obtaining a measure of blood glucose | 72 | 2000 | |
| 6,532,388 Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure | 123 | 2000 | |
| 6,928,320 Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated | 95 | 2001 | |
| 2004/0193,229 Gastric electrical stimulation for treatment of gastro-esophageal reflux disease | 38 | 2003 | |
| 2004/0236,381 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof | 38 | 2003 | |
| 2004/0236,382 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof | 38 | 2003 | |
| 2005/0075,693 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device | 28 | 2004 | |
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| 2004/0172,084 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) | 39 | 2003 | |
| 2004/0172,085 Nerve stimulation and conduction block therapy | 75 | 2003 | |
| 2004/0172,086 Nerve conduction block treatment | 45 | 2003 | |
| 2004/0176,812 Enteric rhythm management | 82 | 2003 | |
| 7,489,969 Vagal down-regulation obesity treatment | 15 | 2003 | |
| 7,167,750 Obesity treatment with electrically induced vagal down regulation | 76 | 2004 | |
| 2005/0070,970 Movement disorder stimulation with neural block | 39 | 2004 | |
| 2005/0070,974 Obesity and eating disorder stimulation treatment with neural block | 47 | 2004 | |
| 2005/0038,484 Controlled vagal blockage therapy | 73 | 2004 | |
| 2005/0131,485 High frequency vagal blockage therapy | 69 | 2005 | |
| 2007/0043,400 Neural electrode treatment | 14 | 2005 | |
| 2007/0135,846 Vagal obesity treatment | 18 | 2007 | |
| 2007/0135,856 Bulimia treatment | 14 | 2007 | |
| 2007/0135,857 GI inflammatory disease treatment | 14 | 2007 | |
| 2007/0135,858 Pancreatitis treatment | 14 | 2007 | |
| 2007/0142,870 Irritable bowel syndrome treatment | 14 | 2007 | |
| 2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders | 18 | 2007 | |
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| 5,188,104 Treatment of eating disorders by nerve stimulation | 349 | 1991 | |
| 5,269,303 Treatment of dementia by nerve stimulation | 242 | 1991 | |
| 5,215,086 Therapeutic treatment of migraine symptoms by stimulation | 295 | 1991 | |
| 5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation | 353 | 1991 | |
| 5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation | 406 | 1991 | |
| 5,231,988 Treatment of endocrine disorders by nerve stimulation | 271 | 1991 | |
| 5,330,515 Treatment of pain by vagal afferent stimulation | 256 | 1992 | |
| 5,263,480 Treatment of eating disorders by nerve stimulation | 276 | 1992 | |
| 5,571,150 Treatment of patients in coma by nerve stimulation | 234 | 1994 | |
| 5,540,730 Treatment of motility disorders by nerve stimulation | 357 | 1995 | |
| 5,707,400 Treating refractory hypertension by nerve stimulation | 293 | 1995 | |
| 6,587,719 Treatment of obesity by bilateral vagus nerve stimulation | 172 | 1999 | |
| 6,473,644 Method to enhance cardiac capillary growth in heart failure patients | 209 | 1999 | |
| 6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation | 162 | 2001 | |
| 6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation | 95 | 2001 | |
| 2007/0027,484 Autonomic nerve stimulation to treat a pancreatic disorder | 28 | 2005 | |
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| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 1 | 2001 | |
| 6,832,114 Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes | 123 | 2001 | |
| 7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials | 75 | 2002 | |
| 2006/0036,293 Methods for treating gastrointestinal disorders | 47 | 2005 | |
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| 6,611,715 Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator | 100 | 2001 | |
| 2003/0212,440 Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system | 104 | 2002 | |
| 7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders | 48 | 2004 | |
| 2005/0137,644 Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders | 39 | 2005 | |
| 2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator | 94 | 2005 | |
| 2005/0149,146 Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator | 76 | 2005 | |
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| 5,437,291 Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction | 186 | 1993 | |
| 6,312,708 Botulinum toxin implant | 137 | 2000 | |
| 6,261,572 Method for treating a pancreatic disorder with a neurotoxin | 45 | 2000 | |
| 2001/0012,828 Intraspinal botulinum toxin for treating pain | 16 | 2001 | |
| 2004/0086,531 Methods for treating ulcers and gastroesophageal reflux disease | 27 | 2002 | |
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| 6,684,105 Treatment of disorders by unidirectional nerve stimulation | 162 | 2001 | |
| 2003/0045,909 Selective nerve fiber stimulation for treating heart conditions | 172 | 2002 | |
| 2004/0243,182 Treatment of disorders by unidirectional nerve stimulation | 76 | 2004 | |
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| 4,702,254 Neurocybernetic prosthesis | 315 | 1985 | |
| 4,867,164 Neurocybernetic prosthesis | 291 | 1987 | |
| 5,025,807 Neurocybernetic prosthesis | 245 | 1989 | |
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| 2004/0181,178 Methods and apparatus for treatment of obesity | 31 | 2003 | |
| 2005/0203,501 Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes | 34 | 2005 | |
| 2006/0015,151 Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures | 27 | 2005 | |
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| 2003/0181,958 Electric modulation of sympathetic nervous system | 116 | 2002 | |
| 2006/0190,053 Neural stimulation for treatment of metabolic syndrome and type 2 diabetes | 23 | 2006 | |
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| 7,072,720 Devices and methods for vagus nerve stimulation | 43 | 2002 | |
| 7,142,910 Methods of indirectly stimulating the vagus nerve with an electrical field | 33 | 2004 | |
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| 6,571,127 Method of increasing the motility of a GI tract | 134 | 2000 | |
| 6,993,391 Acute and chronic electrical signal therapy for obesity | 29 | 2003 | |
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| 5,423,872 Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient | 243 | 1993 | |
| 2002/0072,780 Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity | 80 | 2001 | |
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| 5,601,604 Universal gastric band | 183 | 1993 | |
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| 6,292,703 Neural electrode arrangement | 70 | 1999 | |
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| 6,826,428 Gastrointestinal electrical stimulation | 127 | 2002 | |
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| 6,148,222 Esophageal catheters and method of use | 81 | 1998 | |
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| 5,199,430 Micturitional assist device | 96 | 1991 | |
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| 6,558,708 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia | 43 | 2000 | |
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| 5,716,385 Crural diaphragm pacemaker and method for treating esophageal reflux disease | 66 | 1996 | |
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| 5,514,175 Auricular electrical stimulator | 74 | 1994 | |
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| 2004/0254,616 Stimulus regimens for cardiovascular reflex control | 77 | 2004 | |
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| 2004/0110,551 UNLOADER TUBE CLEANING SYSTEM FOR HARVESTING APPARATUS | 4 | 2002 | |
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| 2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease | 118 | 2002 | |
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| 5,747,060 Prolonged local anesthesia with colchicine | 72 | 1996 | |
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| 6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures | 245 | 1999 | |
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| 2006/0212,089 Device for the desynchronization of neuronal brain activity | 20 | 2004 | |
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| 6,111,715 Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents | 22 | 1998 | |
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| 5,226,429 Laparoscopic gastric band and method | 299 | 1991 | |
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| 6,364,899 Heat pipe nerve cooler | 92 | 1999 | |
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| 7,054,690 Gastrointestinal stimulation device | 44 | 2003 | |
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| 5,620,955 Bombesin receptor antagonists and uses thereof | 25 | 1993 | |
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| 2002/0094,962 Motilide compounds | 21 | 2001 | |
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| 2003/0181,959 Wireless electric modulation of sympathetic nervous system | 61 | 2002 | |
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| 6,405,732 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors | 142 | 1999 | |
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| 5,830,434 Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide | 19 | 1997 | |
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| 6,895,278 Gastric stimulator apparatus and method for use | 82 | 1999 | |
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| 5,836,994 Method and apparatus for electrical stimulation of the gastrointestinal tract | 198 | 1997 | |
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| 4,198,963 Cardiopulmonary resuscitator, defibrillator and monitor | 92 | 1978 | |
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| 2006/0030,919 Devices, systems, and methods employing a molded nerve cuff electrode | 35 | 2005 | |
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| 6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders | 154 | 2000 | |
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| 4,541,432 Electric nerve stimulator device | 128 | 1982 | |
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| 6,746,474 Apparatus and methods for cooling a region within the body | 39 | 2002 | |
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| 5,749,907 System and method for identifying and displaying medical data which violate programmable alarm conditions | 278 | 1997 | |
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| 2005/0143,378 Treatment of conditions through pharmacological modulation of the autonomic nervous system | 16 | 2003 | |
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| 2003/0195,601 High-density array of micro-machined electrodes for neural stimulation | 31 | 2002 | |
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| 6,369,079 Methods for treating irritable bowel syndrome using optically pure (+) norcisapride | 19 | 2000 | |
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| 6,290,961 Method for treating dystonia with botulinum toxin type B | 32 | 2000 | |
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| 6,449,511 Gastrointestinal electrical stimulator having a variable electrical stimulus | 80 | 2000 | |
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| 6,098,629 Submucosal esophageal bulking device | 149 | 1999 | |
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| 6,610,713 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation | 131 | 2001 | |
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| 2002/0055,779 NEURAL PROSTHESIS | 81 | 1997 | |
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| 5,690,691 Gastro-intestinal pacemaker having phased multi-point stimulation | 280 | 1996 | |
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| 6,243,607 Gastro-intestinal electrical pacemaker | 106 | 1999 | |
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| 5,370,675 Medical probe device and method | 723 | 1993 | |
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| 6,129,726 Medical probe device and method | 63 | 1999 | |
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| 4,776,349 Tubular device for the treatment of hollow organs with electric current | 135 | 1986 | |
| 5,292,344 Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port | 165 | 1992 | |
| 2004/0036,377 HIGH VOLTAGE LC ELECTRIC AND MAGNETIC FIELD MOTIVATOR | 13 | 2001 | |
| 2006/0229,685 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) | 8 | 2006 | |
Patent Citation Ranking
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