US Patent No: 7,729,771

Number of patents in Portfolio can not be more than 2000

Nerve stimulation and blocking for treatment of gastrointestinal disorders

ALSO PUBLISHED AS: 20080021512
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Abstract

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At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ENTEROMEDICS INC.ST PAUL, MN33

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conrad, Timothy R Eden Prairie, MN 153 2739
Knudson, Mark B Shoreview, MN 204 7690
Tweden, Katherine S Mahtomedi, MN 89 2253
Wilson, Richard R Seattle, WA 84 1255

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MEDTRONIC, INC. (24)
5,344,438 Cuff electrode 112 1993
5,861,014 Method and apparatus for sensing a stimulating gastrointestinal tract on-demand 217 1997
6,216,039 Method and apparatus for treating irregular gastric rhythms 87 1997
5,919,216 System and method for enhancement of glucose production by stimulation of pancreatic beta cells 140 1997
6,093,167 System for pancreatic stimulation and glucose measurement 166 1997
5,967,977 Transesophageal medical lead 70 1997
6,091,992 Method and apparatus for electrical stimulation of the gastrointestinal tract 144 1997
6,104,955 Method and apparatus for electrical stimulation of the gastrointestinal tract 148 1997
6,083,249 Apparatus for sensing and stimulating gastrointestinal tract on-demand 194 1998
5,995,872 Method and apparatus for electrical stimulation of the gastrointestinal tract 183 1998
6,097,984 System and method of stimulation for treating gastro-esophageal reflux disease 164 1998
6,135,978 System for pancreatic stimulation and glucose measurement 306 1999
6,308,105 Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms 60 1999
6,238,423 Apparatus and method for treating chronic constipation 111 1999
6,418,346 Apparatus and method for remote therapy and diagnosis in medical devices via interface systems 248 1999
6,612,983 Pancreatic secretion response to stimulation test protocol 86 2000
6,853,862 Gastroelectric stimulation for influencing pancreatic secretions 111 2000
6,261,280 Method of obtaining a measure of blood glucose 87 2000
6,532,388 Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure 178 2000
6,928,320 Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated 147 2001
2004/0193,229 Gastric electrical stimulation for treatment of gastro-esophageal reflux disease 50 2003
2004/0236,381 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 48 2003
2004/0236,382 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof 49 2003
2005/0075,693 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device 42 2004
 
EnteroMedics Inc. (17)
2004/0172,084 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 55 2003
2004/0172,085 Nerve stimulation and conduction block therapy 101 2003
2004/0172,086 Nerve conduction block treatment 56 2003
2004/0176,812 Enteric rhythm management 109 2003
7,489,969 Vagal down-regulation obesity treatment 21 2003
7,167,750 Obesity treatment with electrically induced vagal down regulation 126 2004
2005/0070,970 Movement disorder stimulation with neural block 55 2004
2005/0070,974 Obesity and eating disorder stimulation treatment with neural block 61 2004
2005/0038,484 Controlled vagal blockage therapy 114 2004
2005/0131,485 High frequency vagal blockage therapy 99 2005
2007/0043,400 Neural electrode treatment 18 2005
2007/0135,846 Vagal obesity treatment 26 2007
2007/0135,856 Bulimia treatment 21 2007
2007/0135,857 GI inflammatory disease treatment 22 2007
2007/0135,858 Pancreatitis treatment 21 2007
2007/0142,870 Irritable bowel syndrome treatment 21 2007
2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 29 2007
 
CYBERONICS, INC. (16)
5,188,104 Treatment of eating disorders by nerve stimulation 428 1991
5,269,303 Treatment of dementia by nerve stimulation 320 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 388 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 461 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 559 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 394 1991
5,330,515 Treatment of pain by vagal afferent stimulation 340 1992
5,263,480 Treatment of eating disorders by nerve stimulation 372 1992
5,571,150 Treatment of patients in coma by nerve stimulation 321 1994
5,540,730 Treatment of motility disorders by nerve stimulation 475 1995
5,707,400 Treating refractory hypertension by nerve stimulation 430 1995
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 239 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 318 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 217 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 141 2001
2007/0027,484 Autonomic nerve stimulation to treat a pancreatic disorder 38 2005
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (8)
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 5 2001
6,832,114 Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes 174 2001
7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 133 2002
2006/0036,293 Methods for treating gastrointestinal disorders 64 2005
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (6)
6,611,715 Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator 130 2001
2003/0212,440 Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system 151 2002
7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders 69 2004
2005/0137,644 Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders 54 2005
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 148 2005
2005/0149,146 Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator 102 2005
 
ALLERGAN, INC. (5)
5,437,291 Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction 213 1993
6,312,708 Botulinum toxin implant 159 2000
6,261,572 Method for treating a pancreatic disorder with a neurotoxin 48 2000
2001/0012,828 Intraspinal botulinum toxin for treating pain 22 2001
2004/0086,531 Methods for treating ulcers and gastroesophageal reflux disease 41 2002
 
ACTIVE PROTECTIVE TECHNOLOGIES, INC. (3)
2005/0067,816 Method and apparatus for body impact protection 2004
2005/0067,816 Method and apparatus for body impact protection 2004
2005/0067,816 Method and apparatus for body impact protection 2004
 
CIT GROUP/BUSINESS CREDIT, INC. (3)
4,702,254 Neurocybernetic prosthesis 388 1985
4,867,164 Neurocybernetic prosthesis 357 1987
5,025,807 Neurocybernetic prosthesis 315 1989
 
ENDOVX, INC. (3)
2004/0181,178 Methods and apparatus for treatment of obesity 34 2003
2005/0203,501 Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes 41 2005
2006/0015,151 Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures 40 2005
 
ADVANCED NEUROMODULATION SYSTEMS, INC. (2)
2003/0181,958 Electric modulation of sympathetic nervous system 150 2002
2006/0190,053 Neural stimulation for treatment of metabolic syndrome and type 2 diabetes 29 2006
 
BIOCONTROL MEDICAL LTD. (2)
2003/0045,909 Selective nerve fiber stimulation for treating heart conditions 245 2002
2004/0243,182 Treatment of disorders by unidirectional nerve stimulation 112 2004
 
EMORY UNIVERSITY (2)
7,072,720 Devices and methods for vagus nerve stimulation 74 2002
7,142,910 Methods of indirectly stimulating the vagus nerve with an electrical field 50 2004
 
JPMORGAN CHASE BANK, N.A. (2)
2002/0062,071 Manual and automatic probe calibration 2 2001
2002/0062,071 Manual and automatic probe calibration 2 2001
 
METACURE LIMITED (2)
6,571,127 Method of increasing the motility of a GI tract 198 2000
6,993,391 Acute and chronic electrical signal therapy for obesity 37 2003
 
TRANSNEURONIX, INC. (2)
5,423,872 Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient 293 1993
2002/0072,780 Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity 94 2001
 
BIO CONTROL MEDICAL (B.C.M.) LTD. (1)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 238 2001
 
BIOENTERIES CORPORATION (1)
5,601,604 Universal gastric band 222 1993
 
Biotronik Mess-und Therapiegeraete GmbH & Co. (1)
6,292,703 Neural electrode arrangement 106 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,826,428 Gastrointestinal electrical stimulation 162 2002
 
CARDIOCOMMAND, INC. (1)
6,148,222 Esophageal catheters and method of use 97 1998
 
CASE WESTERN RESERVE UNIVERSITY (1)
5,199,430 Micturitional assist device 116 1991
 
CEDARS-SINAI MEDICAL CENTER (1)
6,558,708 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia 53 2000
 
CENTER FOR INNOVATIVE TECHNOLOGY, THE (1)
5,716,385 Crural diaphragm pacemaker and method for treating esophageal reflux disease 85 1996
 
Cerebral Stimulation, Inc. (1)
5,514,175 Auricular electrical stimulator 108 1994
 
CVRX, INC. (1)
2004/0254,616 Stimulus regimens for cardiovascular reflex control 124 2004
 
DEERE & COMPANY (1)
2004/0110,551 UNLOADER TUBE CLEANING SYSTEM FOR HARVESTING APPARATUS 4 2002
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 174 2002
 
EURO-CELTIQUE S.A. (1)
5,747,060 Prolonged local anesthesia with colchicine 109 1996
 
FLINT HILLS SCIENTIFIC, LLC (1)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 366 1999
 
FORSCHUNGSZENTRUM JULICH GMBH (1)
2006/0212,089 Device for the desynchronization of neuronal brain activity 27 2004
 
HITACHI GLOBAL STORAGE TECHNOLOGIES JAPAN, LTD. (1)
6,111,715 Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents 24 1998
 
INAMED DEVELOPMENT COMPANY (1)
5,226,429 Laparoscopic gastric band and method 359 1991
 
INNERCOOL THERAPIES, INC., A DELAWARE CORPORATION (1)
6,364,899 Heat pipe nerve cooler 99 1999
 
INTRAPACE, INC. (1)
7,054,690 Gastrointestinal stimulation device 63 2003
 
KNIGHT, MARTHA (1)
5,620,955 Bombesin receptor antagonists and uses thereof 29 1993
 
KOSAN BIOSCIENCES, INC. (1)
2002/0094,962 Motilide compounds 23 2001
 
LEPTOS BIODMEDICAL, INC. (1)
2003/0181,959 Wireless electric modulation of sympathetic nervous system 75 2002
 
MEDERI THERAPEUTICS, INC. (1)
6,405,732 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 198 1999
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
5,830,434 Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide 22 1997
 
MEDTRONIC TRANSNEURONIX, INC. (1)
6,895,278 Gastric stimulator apparatus and method for use 94 1999
 
Michael J. Jaro (1)
5,836,994 Method and apparatus for electrical stimulation of the gastrointestinal tract 240 1997
 
Michigan Instruments, Inc. (1)
4,198,963 Cardiopulmonary resuscitator, defibrillator and monitor 105 1978
 
NDI MEDICAL, LLC (1)
2006/0030,919 Devices, systems, and methods employing a molded nerve cuff electrode 46 2005
 
NEUROPACE, INC. (1)
6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 179 2000
 
NEUROTRONIC LTEE 11251 RUE NOTRE-DAME EST, MONTREAL, QUEBEC, CANADA H1B 2W2 (1)
4,541,432 Electric nerve stimulator device 162 1982
 
NIDUS MEDICAL, LLC (1)
6,746,474 Apparatus and methods for cooling a region within the body 52 2002
 
PACESETTER, INC. (1)
5,749,907 System and method for identifying and displaying medical data which violate programmable alarm conditions 391 1997
 
PALO ALTO INVESTORS (1)
2005/0143,378 Treatment of conditions through pharmacological modulation of the autonomic nervous system 19 2003
 
SECOND SIGHT MEDICAL PRODUCTS, INC. (1)
2003/0195,601 High-density array of micro-machined electrodes for neural stimulation 38 2002
 
SEPRACOR INC. (1)
6,369,079 Methods for treating irritable bowel syndrome using optically pure (+) norcisapride 22 2000
 
SOLSTICE NEUROSCIENCES, LLC (1)
6,290,961 Method for treating dystonia with botulinum toxin type B 38 2000
 
TECHNOLOGIES INTERNATIONAL INC., UNIVERSITY (1)
6,449,511 Gastrointestinal electrical stimulator having a variable electrical stimulus 105 2000
 
THD S.P.A. (1)
6,098,629 Submucosal esophageal bulking device 168 1999
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (1)
6,610,713 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 215 2001
 
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (1)
2002/0055,779 NEURAL PROSTHESIS 113 1997
 
UNIVERSITY OF VIRGINIA (1)
5,690,691 Gastro-intestinal pacemaker having phased multi-point stimulation 370 1996
 
UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (1)
6,243,607 Gastro-intestinal electrical pacemaker 126 1999
 
VENTURE LENDING & LEASING, INC. (1)
5,370,675 Medical probe device and method 810 1993
 
VIDAMED, INC. (1)
6,129,726 Medical probe device and method 81 1999
 
Other [Check patent profile for assignment information] (4)
4,776,349 Tubular device for the treatment of hollow organs with electric current 147 1986
5,292,344 Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port 198 1992
2004/0036,377 HIGH VOLTAGE LC ELECTRIC AND MAGNETIC FIELD MOTIVATOR 18 2001
2006/0229,685 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 11 2006

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
EnteroMedics Inc. (8)
7,844,338 High frequency obesity treatment 13 2004
7,986,995 Bulimia treatment 5 2007
8,103,349 Neural electrode treatment 6 2009
8,010,204 Nerve blocking for treatment of gastrointestinal disorders 3 2010
8,046,085 Controlled vagal blockage therapy 7 2010
8,369,952 Bulimia treatment 2 2011
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2011
8,538,533 Controlled vagal blockage therapy 0 2011
 
ENDOSTIM, INC. (1)
8,798,753 Device and implantation system for electrical stimulation of biological systems 0 2013

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