US Patent No: 7,729,771

Number of patents in Portfolio can not be more than 2000

Nerve stimulation and blocking for treatment of gastrointestinal disorders

1 Status Updates

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
ENTEROMEDICS INC.ST PAUL, MN40

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Conrad, Timothy R Eden Prairie, US 95 4119
Knudson, Mark B Shoreview, US 145 10361
Tweden, Katherine S Mahtomedi, US 66 3324
Wilson, Richard R Arden Hills, US 58 2330

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (4)
4,776,349 Tubular device for the treatment of hollow organs with electric current 167 1986
5,292,344 Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system, with optional delivery port 228 1992
2004/0036,377 HIGH VOLTAGE LC ELECTRIC AND MAGNETIC FIELD MOTIVATOR 23 2001
2006/0229,685 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 16 2006
 
University Technologies International, Inc. (1)
6,243,607 Gastro-intestinal electrical pacemaker 152 1999
 
Advanced Neuromodulation Systems, Inc. (2)
2003/0181,958 Electric modulation of sympathetic nervous system 201 2002
2006/0190,053 Neural stimulation for treatment of metabolic syndrome and type 2 diabetes 45 2006
 
HITACHI GLOBAL STORAGE TECHNOLOGIES JAPAN, LTD. (1)
6,111,715 Storage apparatus using a magnetoresistive head that employs a sense current selected from plural predetermined sense currents 29 1998
 
Mederi Therapeutics, Inc. (1)
6,405,732 Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors 316 1999
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,826,428 Gastrointestinal electrical stimulation 210 2002
 
NDI MEDICAL, LLC (1)
2006/0030,919 Devices, systems, and methods employing a molded nerve cuff electrode 70 2005
 
NEUROTRONIC LTEE 11251 RUE NOTRE-DAME EST, MONTREAL, QUEBEC, CANADA H1B 2W2 (1)
4,541,432 Electric nerve stimulator device 222 1982
 
Kosan Biosciences, Inc. (1)
2002/0094,962 Motilide compounds 28 2001
 
DILORENZO BIOMEDICAL, LLC (1)
2003/0018,367 Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease 251 2002
 
INNERCOOL THERAPIES, INC. (1)
6,364,899 Heat pipe nerve cooler 114 1999
 
VENTURE LENDING & LEASING, INC. A CORP. OF CALIFORNIA (1)
5,370,675 Medical probe device and method 910 1993
 
Bio Control Medical (B.C.M.) Ltd. (3)
6,684,105 Treatment of disorders by unidirectional nerve stimulation 329 2001
2003/0045,909 Selective nerve fiber stimulation for treating heart conditions 316 2002
* 2004/0243,182 Treatment of disorders by unidirectional nerve stimulation 186 2004
 
Pacesetter, Inc. (1)
5,749,907 System and method for identifying and displaying medical data which violate programmable alarm conditions 472 1997
 
UNIVERSITY OF VIRGINIA (1)
5,690,691 Gastro-intestinal pacemaker having phased multi-point stimulation 459 1996
 
Endovx, Inc. (3)
2004/0181,178 Methods and apparatus for treatment of obesity 43 2003
2005/0203,501 Methods and apparatus for treatment of obesity with an ultrasound device movable in two or three axes 60 2005
2006/0015,151 Method of using endoscopic truncal vagoscopy with gastric bypass, gastric banding and other procedures 63 2005
 
LEPTOS BIODMEDICAL, INC. (1)
2003/0181,959 Wireless electric modulation of sympathetic nervous system 90 2002
 
Center for Innovative Technology (1)
5,716,385 Crural diaphragm pacemaker and method for treating esophageal reflux disease 107 1996
 
KNIGHT, MARTHA (1)
5,620,955 Bombesin receptor antagonists and uses thereof 36 1993
 
INTRAPACE, INC. (1)
7,054,690 Gastrointestinal stimulation device 102 2003
 
SOLSTICE NEUROSCIENCES, LLC (1)
6,290,961 Method for treating dystonia with botulinum toxin type B 46 2000
 
Cerebral Stimulation, Inc. (1)
5,514,175 Auricular electrical stimulator 165 1994
 
EMORY UNIVERSITY (2)
7,072,720 Devices and methods for vagus nerve stimulation 157 2002
7,142,910 Methods of indirectly stimulating the vagus nerve with an electrical field 76 2004
 
Palo Alto Investors (1)
2005/0143,378 Treatment of conditions through pharmacological modulation of the autonomic nervous system 31 2003
 
CIT GROUP/BUSINESS CREDIT, INC., THE, AS AGENT (3)
4,702,254 Neurocybernetic prosthesis 453 1985
4,867,164 Neurocybernetic prosthesis 420 1987
5,025,807 Neurocybernetic prosthesis 378 1989
 
Michael J. Jaro (1)
5,836,994 Method and apparatus for electrical stimulation of the gastrointestinal tract 278 1997
 
ALLERGAN, INC. (5)
5,437,291 Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction 245 1993
6,312,708 Botulinum toxin implant 192 2000
6,261,572 Method for treating a pancreatic disorder with a neurotoxin 56 2000
2001/0012,828 Intraspinal botulinum toxin for treating pain 28 2001
2004/0086,531 Methods for treating ulcers and gastroesophageal reflux disease 59 2002
 
MEDICAL UNIVERSITY OF SOUTH CAROLINA (1)
5,830,434 Methods of treating non-insulin dependent diabetes mellitus with pancreatic polypeptide 27 1997
 
TECHNOLOGIES INTERNATIONAL INC., UNIVERSITY (1)
6,449,511 Gastrointestinal electrical stimulator having a variable electrical stimulus 132 2000
 
Medtronic Transneuronix, Inc. (1)
6,895,278 Gastric stimulator apparatus and method for use 109 1999
 
CYBERONICS, INC. (16)
5,188,104 Treatment of eating disorders by nerve stimulation 523 1991
5,269,303 Treatment of dementia by nerve stimulation 444 1991
5,215,086 Therapeutic treatment of migraine symptoms by stimulation 499 1991
5,299,569 Treatment of neuropsychiatric disorders by nerve stimulation 611 1991
5,335,657 Therapeutic treatment of sleep disorder by nerve stimulation 756 1991
5,231,988 Treatment of endocrine disorders by nerve stimulation 548 1991
5,330,515 Treatment of pain by vagal afferent stimulation 449 1992
5,263,480 Treatment of eating disorders by nerve stimulation 485 1992
5,571,150 Treatment of patients in coma by nerve stimulation 422 1994
5,540,730 Treatment of motility disorders by nerve stimulation 612 1995
5,707,400 Treating refractory hypertension by nerve stimulation 639 1995
6,587,719 Treatment of obesity by bilateral vagus nerve stimulation 344 1999
6,473,644 Method to enhance cardiac capillary growth in heart failure patients 428 1999
6,609,025 Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation 283 2001
6,622,038 Treatment of movement disorders by near-diaphragmatic nerve stimulation 197 2001
2007/0027,484 Autonomic nerve stimulation to treat a pancreatic disorder 64 2005
 
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (1)
2002/0055,779 NEURAL PROSTHESIS 167 1997
 
SECOND SIGHT MEDICAL PRODUCTS, INC. (1)
2003/0195,601 High-density array of micro-machined electrodes for neural stimulation 48 2002
 
EURO-CELTIQUE S.A. (1)
5,747,060 Prolonged local anesthesia with colchicine 156 1996
 
NIDUS MEDICAL, LLC (1)
6,746,474 Apparatus and methods for cooling a region within the body 106 2002
 
Vidamed, Inc. (1)
6,129,726 Medical probe device and method 111 1999
 
MEDTRONIC, INC. (24)
5,344,438 Cuff electrode 162 1993
5,861,014 Method and apparatus for sensing a stimulating gastrointestinal tract on-demand 265 1997
6,216,039 Method and apparatus for treating irregular gastric rhythms 105 1997
5,919,216 System and method for enhancement of glucose production by stimulation of pancreatic beta cells 181 1997
6,093,167 System for pancreatic stimulation and glucose measurement 225 1997
5,967,977 Transesophageal medical lead 78 1997
6,091,992 Method and apparatus for electrical stimulation of the gastrointestinal tract 188 1997
6,104,955 Method and apparatus for electrical stimulation of the gastrointestinal tract 173 1997
6,083,249 Apparatus for sensing and stimulating gastrointestinal tract on-demand 258 1998
5,995,872 Method and apparatus for electrical stimulation of the gastrointestinal tract 239 1998
6,097,984 System and method of stimulation for treating gastro-esophageal reflux disease 199 1998
6,135,978 System for pancreatic stimulation and glucose measurement 386 1999
6,308,105 Medical electrical stimulation system using an electrode assembly having opposing semi-circular arms 88 1999
6,238,423 Apparatus and method for treating chronic constipation 158 1999
6,418,346 Apparatus and method for remote therapy and diagnosis in medical devices via interface systems 340 1999
6,612,983 Pancreatic secretion response to stimulation test protocol 107 2000
6,853,862 Gastroelectric stimulation for influencing pancreatic secretions 137 2000
6,261,280 Method of obtaining a measure of blood glucose 113 2000
6,532,388 Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure 239 2000
6,928,320 Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated 226 2001
2004/0193,229 Gastric electrical stimulation for treatment of gastro-esophageal reflux disease 73 2003
2004/0236,381 Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof 69 2003
2004/0236,382 Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof 67 2003
2005/0075,693 Driver circuitry switchable between energy transfer and telemetry for an implantable medical device 59 2004
 
NEURO AND CARDIAC TECHNOLOGIES, LLC (6)
6,611,715 Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator 190 2001
2003/0212,440 Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system 203 2002
7,076,307 Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders 105 2004
2005/0137,644 Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders 103 2005
2005/0143,787 Method and system for providing electrical pulses for neuromodulation of vagus nerve(s), using rechargeable implanted pulse generator 221 2005
2005/0149,146 Method and system to provide therapy for obesity and other medical disorders, by providing electrical pules to symapthetic nerves or vagal nerve(s) with rechargeable implanted pulse generator 136 2005
 
FLINT HILLS SCIENTIFIC, LLC (1)
6,341,236 Vagal nerve stimulation techniques for treatment of epileptic seizures 515 1999
 
NEUROPACE, INC. (1)
6,591,137 Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders 221 2000
 
JPMORGAN CHASE BANK, N.A. (2)
2002/0062,071 Manual and automatic probe calibration 15 2001
2002/0062,071 Manual and automatic probe calibration 15 2001
 
METACURE LIMITED (2)
6,571,127 Method of increasing the motility of a GI tract 289 2000
6,993,391 Acute and chronic electrical signal therapy for obesity 48 2003
 
THD S.p.A. (1)
6,098,629 Submucosal esophageal bulking device 198 1999
 
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (1)
6,610,713 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation 323 2001
 
Transneuronix, Inc. (2)
5,423,872 Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient 341 1993
2002/0072,780 Method and apparatus for intentional impairment of gastric motility and /or efficiency by triggered electrical stimulation of the gastrointestinal tract with respect to the intrinsic gastric electrical activity 123 2001
 
CEDARS-SINAI MEDICAL CENTER (1)
6,558,708 Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia 77 2000
 
BIOTRONIK MESS-UND THERAPIEGERAETE GMBH & CO. INGENIEURBUERO BERLIN (1)
6,292,703 Neural electrode arrangement 137 1999
 
DEERE & COMPANY (1)
2004/0110,551 UNLOADER TUBE CLEANING SYSTEM FOR HARVESTING APPARATUS 4 2002
 
Inamed Development Company (1)
5,226,429 Laparoscopic gastric band and method 444 1991
 
CARDIOCOMMAND, INC. (1)
6,148,222 Esophageal catheters and method of use 120 1998
 
CVRX, INC. (1)
2004/0254,616 Stimulus regimens for cardiovascular reflex control 174 2004
 
SEPRACOR INC. (1)
6,369,079 Methods for treating irritable bowel syndrome using optically pure (+) norcisapride 28 2000
 
EnteroMedics Inc. (17)
2004/0172,084 Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) 76 2003
7,489,969 Vagal down-regulation obesity treatment 36 2003
2004/0172,085 Nerve stimulation and conduction block therapy 138 2003
2004/0172,086 Nerve conduction block treatment 80 2003
2004/0176,812 Enteric rhythm management 150 2003
7,167,750 Obesity treatment with electrically induced vagal down regulation 218 2004
2005/0070,970 Movement disorder stimulation with neural block 83 2004
2005/0070,974 Obesity and eating disorder stimulation treatment with neural block 100 2004
2005/0038,484 Controlled vagal blockage therapy 163 2004
2005/0131,485 High frequency vagal blockage therapy 152 2005
2007/0043,400 Neural electrode treatment 36 2005
2007/0135,846 Vagal obesity treatment 44 2007
2007/0135,856 Bulimia treatment 36 2007
2007/0135,857 GI inflammatory disease treatment 36 2007
2007/0135,858 Pancreatitis treatment 34 2007
2007/0142,870 Irritable bowel syndrome treatment 35 2007
2008/0021,512 Nerve stimulation and blocking for treatment of gastrointestinal disorders 68 2007
 
FORSCHUNGSZENTRUM JUELICH GMBH (1)
2006/0212,089 Device for the desynchronization of neuronal brain activity 37 2004
 
Active Protective Technologies, Inc. (3)
2005/0067,816 Method and apparatus for body impact protection 18 2004
2005/0067,816 Method and apparatus for body impact protection 18 2004
2005/0067,816 Method and apparatus for body impact protection 18 2004
 
CASE WESTERN RESERVE UNIVERSITY (1)
5,199,430 Micturitional assist device 131 1991
 
BIOENTERIES CORPORATION (1)
5,601,604 Universal gastric band 292 1993
 
BOSTON SCIENTIFIC NEUROMODULATION CORPORATION (8)
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders 12 2001
6,832,114 Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes 248 2001
* 7,292,890 Vagus nerve stimulation via unidirectional propagation of action potentials 232 2002
2006/0036,293 Methods for treating gastrointestinal disorders 89 2005
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
EnteroMedics Inc. (15)
7,844,338 High frequency obesity treatment 31 2004
* 2005/0038,484 Controlled vagal blockage therapy 163 2004
7,986,995 Bulimia treatment 12 2007
* 2007/0135,856 Bulimia treatment 36 2007
8,103,349 Neural electrode treatment 15 2009
8,010,204 Nerve blocking for treatment of gastrointestinal disorders 10 2010
8,046,085 Controlled vagal blockage therapy 21 2010
8,825,164 Neural modulation devices and methods 0 2011
8,369,952 Bulimia treatment 4 2011
8,538,542 Nerve stimulation and blocking for treatment of gastrointestinal disorders 1 2011
8,538,533 Controlled vagal blockage therapy 1 2011
8,862,233 Electrode band system and methods of using the system to treat obesity 0 2013
9,174,040 Nerve stimulation and blocking for treatment of gastrointestinal disorders 0 2013
9,162,062 Controlled vagal blockage therapy 0 2013
9,358,395 Neural modulation devices and methods 0 2014
 
ENDOSTIM, INC. (8)
8,831,729 Systems and methods for treating gastroesophageal reflux disease 0 2012
9,020,597 Device and implantation system for electrical stimulation of biological systems 1 2012
9,037,245 Endoscopic lead implantation method 0 2012
8,798,753 Device and implantation system for electrical stimulation of biological systems 0 2013
9,345,879 Device and implantation system for electrical stimulation of biological systems 0 2014
9,061,147 Device and implantation system for electrical stimulation of biological systems 0 2014
* 2015/0057,718 Device and Implantation System for Electrical Stimulation of Biological Systems 0 2014
* 2015/0224,310 Device and Implantation System for Electrical Stimulation of Biological Systems 0 2015
 
Medibotics LLC (2)
9,067,070 Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type 0 2013
9,011,365 Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food 0 2013
* Cited By Examiner

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Dec 1, 2017
11.5 Year Payment $7400.00 $3700.00 $1850.00 Dec 1, 2021
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00