Polyketides and antibiotics produced by combinatorial techniques
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United States of America Patent
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Jun 22, 2010
Grant Date -
Aug 21, 2008
app pub date -
Oct 2, 2006
filing date -
Sep 20, 1993
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Expired
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Abstract
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
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