Heterocyclic compounds as P2X7 ion channel blockers
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United States of America Patent
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Jun 22, 2010
Grant Date -
Jun 5, 2008
app pub date -
Nov 29, 2007
filing date -
Jul 21, 2003
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Abstract
The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II:, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
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