Systems and methods for drug infusion with feedback control
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United States of America Patent
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Jun 29, 2010
Grant Date -
Jun 19, 2008
app pub date -
Dec 18, 2007
filing date -
Dec 19, 2006
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A system and method for infusing a drug under continuous positive pressure (such as convection enhanced deliver) to a target tissue to be treated is particularly useful for post-resection anticancer drug therapy. The system comprises a drug infusion catheter having an expandable device which is expanded within the target tissue such that the target tissue conforms to an outer surface of the expandable device, thereby creating a form of seal around the target volume in order to maintain an effective drug pressure gradient within the target tissue. The system further comprises a sensor to measure a parameter which can be correlated to the degree of conformance between the target tissue and the outer surface of the expandable device. The sensor is coupled to a feedback control system to determine whether there is a loss of conformance, and to adjust the expansion of the expandable device in order to maintain good conformance.
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