Methods and compositions with reduced opalescence
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United States of America Patent
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Jun 29, 2010
Grant Date -
Jun 26, 2008
app pub date -
Oct 12, 2007
filing date -
Oct 12, 2006
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods for reducing the opalescent appearance of a protein preparation by modifying the ionic strength of the preparation, as well as compositions, e.g., pharmaceutical compositions, of concentrated protein with decreased opalescence are disclosed. Purification methods which monitor and/or reduce the salt concentrations at selected steps are also disclosed.
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