Methods and compositions for treatment of lesioned sites of body vessels
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United States of America Patent
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Jun 29, 2010
Grant Date -
Oct 18, 2007
app pub date -
Apr 14, 2006
filing date -
Apr 14, 2006
priority date (Note) -
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Abstract
Methods and compositions for inducing apoptosis of cells, such as macrophages, at a lesioned site of a body vessel are disclosed herein. Nitric oxide can be directly or indirectly delivered to a treatment site to increase macrophage apoptosis. Delivery can include site specific delivery of nitric oxide gas, nitric oxide in aqueous solution or a substance(s) which releases nitric oxide or causes nitric oxide to be generated from an endogenous source. Delivery can be achieved by a delivery system such as a catheter assembly, stent or other suitable device.
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