US Patent No: 7,749,542

Number of patents in Portfolio can not be more than 2000

Opioid agonist/antagonist combinations

ALSO PUBLISHED AS: 20080292694
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Abstract

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The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PURDUE PHARMA L.P.STAMFORD, CT280

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colucci, Robert D Newtown, CT 23 741
Kaiko, Robert F Weston, CT 46 1238

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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4,834,985 Controlled release pharmaceutical composition 185 1987
4,990,341 Controlled release hydromorphone composition 110 1989
5,266,331 Controlled release oxycodone compositions 133 1991
5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 172 1991
5,286,493 Stabilized controlled release formulations having acrylic polymer coating 169 1992
5,549,912 Controlled release oxycodone compositions 125 1993
5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 152 1993
5,478,577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level 140 1993
5,411,745 Powder-layered morphine sulfate formulations 89 1994
5,965,161 Extruded multi-particulates 101 1994
5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 336 1995
5,508,042 Controlled release oxycodone compositions 132 1995
5,968,551 Orally administrable opioid formulations having extended duration of effect 144 1995
5,958,459 Opioid formulations having extended controlled released 84 1995
5,656,295 Controlled release oxycodone compositions 112 1996
5,681,585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 82 1996
5,672,360 Method of treating pain by administering 24 hour oral opioid formulations 138 1996
6,143,322 Method of treating humans with opioid formulations having extended controlled release 95 1997
5,958,452 Extruded orally administrable opioid formulations 127 1997
5,968,547 Method of providing sustained analgesia with buprenorphine 76 1997
6,077,533 Powder-layered oral dosage forms 56 1998
6,228,863 Method of preventing abuse of opioid dosage forms 121 1998
6,277,384 Opioid agonist/antagonist combinations 87 1998
6,103,261 Opioid formulations having extended controlled release 91 1999
6,335,033 Melt-extrusion multiparticulates 66 1999
6,261,599 Melt-extruded orally administrable opioid formulations 106 1999
6,294,195 Orally administrable opioid formulations having extended duration of effect 94 1999
6,375,957 Opioid agonist/opioid antagonist/acetaminophen combinations 114 2000
6,696,088 Tamper-resistant oral opioid agonist formulations 92 2001
6,475,494 Opioid agonist/antagonist combinations 66 2001
2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone 43 2002
2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist 41 2002
6,696,066 Opioid agonist/antagonist combinations 82 2002
2003/0229,111 Naltrexone hydrochloride compositions 14 2003
2004/0186,121 Tamper-resistant oral opioid agonist formulations 35 2003
7,172,767 Opioid agonist / antagonist combinations 45 2003
2006/0182,801 Sequestered antagonist formulations 34 2006
7,419,686 Opioid agonist/antagonist combinations 24 2006
 
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5,622,722 Spheroid formulation 39 1994
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5,670,172 Pharmaceutical spheroid formulation 63 1995
6,024,982 Immediate release tablet cores of insoluble drugs having sustained-release coating 86 1995
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5,763,452 Pharmaceutical compositions and usages 38 1996
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5,879,705 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions 88 1997
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6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same 61 1997
5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions 94 1997
6,077,532 Pharmaceutical ion exchange resin composition 46 1998
6,306,438 Stabilized sustained release tramadol formulations 61 1998
6,399,096 Pharmaceutical formulation 55 1998
6,143,328 Sustained release compositions and a method of preparing pharmaceutical compositions 48 1999
6,162,467 Sustained release compositions and a method of preparing pharmaceutical compositions 68 1999
6,210,714 Immediate release tablet cores of acetaminophen having sustained-release coating 62 2000
6,387,404 Immediate release tablet cores of insoluble drugs having sustained-release coating 63 2001
6,716,449 Controlled-release compositions containing opioid agonist and antagonist 66 2001
6,627,635 Method of preventing abuse of opioid dosage forms 78 2001
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (12)
5,472,943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists 82 1993
5,585,348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 69 1993
5,512,578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists 90 1994
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5,580,876 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 74 1995
5,767,125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 75 1996
6,096,756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 71 1998
6,194,382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 44 1999
2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS 17 1999
6,362,194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 34 2000
6,395,705 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 41 2001
6,765,010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 36 2002
 
MERCK FROSST CANADA LTD. (10)
5,409,944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase 69 1993
5,604,260 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 81 1993
5,436,265 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents 85 1993
5,521,213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 91 1994
5,552,422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents 98 1995
5,536,752 Phenyl heterocycles as COX-2 inhibitors 77 1995
5,550,142 Phenyl heterocycles as cox-2 inhibitors 83 1995
5,510,368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs 87 1995
5,604,253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 70 1995
5,639,780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 69 1995
 
ALZA CORPORATION (6)
4,200,098 Osmotic system with distribution zone for dispensing beneficial agent 312 1978
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5,460,826 Morphine therapy 88 1994
5,866,164 Composition and dosage form comprising opioid antagonist 114 1997
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (6)
4,401,672 Non-addictive narcotic antitussive preparation 57 1981
4,730,048 Gut-selective opiates 77 1985
5,352,680 Delta opioid receptor antagonists to block opioid agonist tolerance and dependence 98 1992
5,457,208 Kappa opioid receptor antagonists 70 1993
5,578,725 Delta opioid receptor antagonists 52 1995
5,780,479 Use of opioid antagonists to treat impulse-control disorders 49 1997
 
UNIVERSITY OF CHICAGO, THE (4)
4,719,215 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 81 1986
4,861,781 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 76 1987
5,102,887 Method for reducing emesis and nausea induced by the administration of an emesis causing agent 76 1990
5,972,954 Use of methylnaltrexone and related compounds 90 1997
 
VIRGINIA COMMONWEALTH UNIVERSITY (4)
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5,321,012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance 117 1993
5,502,058 Method for the treatment of pain 99 1994
5,556,838 Inhibiting the development of tolerance to and/or dependence on an addictive substance 111 1994
 
CONTRAL CLINICS OY (3)
4,882,335 Method for treating alcohol-drinking response 72 1988
5,096,715 Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist 55 1989
5,086,058 Method for treating alcoholism with nalmefene 70 1990
 
NAPP PHARMACEUTICAL GROUP LIMITED (3)
5,591,452 Controlled release formulation 79 1994
6,326,027 Controlled release formulation 70 1995
6,254,887 Controlled release tramadol 64 1996
 
The Rockefeller University (3)
4,987,136 Method for controlling gastrointestinal dysmotility 107 1986
4,769,372 Method of treating patients suffering from chronic pain or chronic cough 81 1986
4,785,000 Method of treating patients suffering from chronic pain or chronic cough 59 1987
 
BASF AKTIENGESELLSCHAFT (2)
4,806,558 Diarylacetylenes and their use in treating acne 50 1985
4,957,681 Preparation of pharmaceutical mixtures 89 1989
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
4,451,470 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans 59 1982
5,593,994 Prostaglandin synthase inhibitors 64 1994
 
Eli Lilly and Company (2)
4,293,539 Controlled release formulations and method of treatment 98 1979
5,998,434 Composition for treating pain 43 1998
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (2)
4,844,909 Controlled release hydromorphone composition 104 1987
4,844,910 Spheroids 49 1987
 
NOVA PHARMACEUTICAL CORPORATION (2)
4,760,069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 63 1985
4,889,860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 66 1987
 
OMEROS CORPORATION (2)
5,858,017 Urologic irrigation solution and method for inhibition of pain, inflammation and spasm 102 1996
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PURDUE PHARMA COMPANY, THE (2)
4,861,598 Controlled release bases for pharmaceuticals 134 1986
4,970,075 Controlled release bases for pharmaceuticals 109 1989
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (2)
4,582,835 Analgesic compositions 100 1984
4,661,492 Analgesic compositions 70 1985
 
Schaap; Robert J. (2)
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5,130,311 Oxazolopyridine compounds, compositions and use 47 1991
 
Aminotek Sciences, Inc. (1)
5,256,669 Methods and compositions for treating acute or chronic pain and drug addiction 56 1992
 
BAKER NORTON PHARMACEUTICALS, INC. (1)
4,873,076 Method of safely providing anesthesia or conscious sedation 59 1989
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,457,933 Prevention of analgesic abuse 98 1981
 
COLMAN PRODUCTS LIMITED (1)
4,935,428 Treating opiate dependence 69 1988
 
DUPONT MERCK PHARMACEUTICAL COMPANY, THE (1)
4,722,928 N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes 22 1985
 
DUPONT PHARMACEUTICALS COMPANY (1)
4,237,140 Analgesic mixture of nalbuphine and acetaminophen 54 1979
 
DYNAGEN, INC. (1)
5,486,362 Controlled, sustained release delivery system for treating drug dependency 94 1993
 
ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (1)
5,869,097 Method of therapy comprising an osmotic caplet 59 1992
 
G. D. Searle & Co. (1)
5,616,601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation 115 1995
 
GENERAL ELECTRIC COMPANY (1)
5,226,331 Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream 41 1991
 
ICN HUNGARY RT. (1)
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LIFESHIELD SCIENCES LLC (1)
2004/0158,312 Braided endoluminal device having tapered filaments 5 2003
 
McGinnis; Carolyn (1)
4,608,376 Opiate agonists and antagonists 48 1982
 
MERCK FROSST COMPANY (1)
5,474,995 Phenyl heterocycles as cox-2 inhibitors 149 1994
 
MERCK SHARP & DOHME LTD. (1)
5,880,132 Tachykinin antagonist and an opioid analgesic effective at treating pain or nociception 55 1997
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,225,440 Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase 55 1991
 
OREGON, UNIVERSITY OF (1)
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ORTHO-MCNEIL PHARMACEUTICAL, INC. (1)
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PEPTECH LIMITED (1)
5,534,492 Muramyl peptide for the treatment of toxicity 45 1995
 
PUREUE PHARMA L.P. (1)
4,834,984 Controlled release dihydrocodeine composition 99 1987
 
RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
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SCULLY SCOTT MURPHY & PRESSER, PC (1)
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SIMON, DAVID L. (1)
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SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (1)
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THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
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THE MCLEAN HOSPITAL CORPORATION (1)
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The United States of America as represented by the Secretary of the Army (1)
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United Biomedical, Inc. (1)
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Warner-Lambert Company (1)
5,149,538 Misuse-resistive transdermal opioid dosage form 139 1991
 
YOUNG, JACQUELINE, MS. (1)
5,356,900 Method of treating chronic herpes virus infections using an opiate receptor antagonist 52 1993
 
Other [Check patent profile for assignment information] (7)
4,464,378 Method of administering narcotic antagonists and analgesics and novel dosage forms containing same 144 1981
4,443,428 Extended action controlled release compositions 81 1982
5,376,662 Method of attenuating nerve injury induced pain 50 1993
2004/0092,542 Tamper-resistant oral opioid agonist formulations 29 2003
2005/0095,291 Tamper-resistant oral opioid agonist formulations 40 2003
2005/0181,046 Tamper-resistant oral opioid agonist formulations 30 2003
2006/0039,970 Tamper-resistant oral opioid agonist formulations 21 2003

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
PURDUE PHARMA L.P. (6)
8,518,925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 0 2005
8,105,631 Opioid agonist/antagonist combinations 7 2010
8,673,355 Opioid agonist/antagonist combinations 0 2011
8,846,090 Matrix for sustained, invariant and independent release of active compounds 0 2012
8,822,487 Opioid agonist/opioid antagonist/acetaminophen combinations 0 2012
8,846,091 Matrix for sustained, invariant and independent release of active compounds 0 2013
 
EGALET LTD. (2)
8,877,241 Morphine controlled release system 0 2004
8,808,745 Morphine polymer release system 0 2013

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