Opioid agonist/antagonist combinations

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO

7749542

APP PUB NO

20080292694A1

SERIAL NO

12220760

1 Status Updates

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PURDUE PHARMA L.P.STAMFORD, CT397

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colucci, Robert D Newtown, US 21 1465
Kaiko, Robert F Weston, US 46 2401

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
5376662 Method of attenuating nerve injury induced pain 72 1993
2004/0092,542 Tamper-resistant oral opioid agonist formulations 51 2003
2005/0095,291 Tamper-resistant oral opioid agonist formulations 63 2003
2005/0181,046 Tamper-resistant oral opioid agonist formulations 54 2003
2006/0039,970 Tamper-resistant oral opioid agonist formulations 38 2003
 
NOVA PHARMACEUTICAL CORPORATION (2)
4760069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 86 1985
4889860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 91 1987
 
The Lynx Project Limited (1)
6310072 Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist 68 1997
 
VIRGINIA COMMONWEALTH UNIVERSITY (4)
5352683 Method for the treatment of chronic pain 118 1993
5321012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance 179 1993
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Warner-Lambert Company (1)
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THE UNIVERSITY OF CHICAGO (4)
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University of Oregon (1)
5514680 Glycine receptor antagonists and the use thereof 104 1993
 
MERCK FROSST COMPANY (1)
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CONTRAL CLINICS OY (3)
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5356900 Method of treating chronic herpes virus infections using an opiate receptor antagonist 75 1993
 
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5409944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase 108 1993
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5436265 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents 126 1993
5521213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 133 1994
5552422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents 144 1995
5536752 Phenyl heterocycles as COX-2 inhibitors 121 1995
5550142 Phenyl heterocycles as cox-2 inhibitors 125 1995
5510368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs 126 1995
5604253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 113 1995
5639780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 114 1995
 
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4844907 Pharmaceutical composition comprising analgesic and anti-inflammatory agent 152 1986
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5091189 Controlled release dosage forms having a defined water content 60 1991
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5500227 Immediate release tablet cores of insoluble drugs having sustained-release coating 196 1993
5622722 Spheroid formulation 59 1994
5508043 Controlled release matrix for pharmaceuticals 78 1995
5670172 Pharmaceutical spheroid formulation 100 1995
6024982 Immediate release tablet cores of insoluble drugs having sustained-release coating 142 1995
5811126 Controlled release matrix for pharmaceuticals 124 1995
5763452 Pharmaceutical compositions and usages 58 1996
5849240 Method of preparing sustained release pharmaceutical compositions 174 1996
5891471 Pharmaceutical multiparticulates 153 1996
5601845 Pharmaceutical spheroid formulation 105 1996
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5965163 Substained release compositions and a method of preparing pharmaceutical compositions 164 1997
6077532 Pharmaceutical ion exchange resin composition 67 1998
6306438 Stabilized sustained release tramadol formulations 95 1998
6399096 Pharmaceutical formulation 103 1998
6143328 Sustained release compositions and a method of preparing pharmaceutical compositions 77 1999
6162467 Sustained release compositions and a method of preparing pharmaceutical compositions 131 1999
6210714 Immediate release tablet cores of acetaminophen having sustained-release coating 104 2000
6387404 Immediate release tablet cores of insoluble drugs having sustained-release coating 117 2001
6627635 Method of preventing abuse of opioid dosage forms 142 2001
 
PURDUE PHARMA L.P. (40)
4828836 Controlled release pharmaceutical composition 220 1987
4834985 Controlled release pharmaceutical composition 232 1987
4990341 Controlled release hydromorphone composition 178 1989
5266331 Controlled release oxycodone compositions 248 1991
5273760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 260 1991
5286493 Stabilized controlled release formulations having acrylic polymer coating 256 1992
5549912 Controlled release oxycodone compositions 241 1993
5472712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 244 1993
5478577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level 255 1993
5411745 Powder-layered morphine sulfate formulations 157 1994
5965161 Extruded multi-particulates 189 1994
5639476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 523 1995
5508042 Controlled release oxycodone compositions 262 1995
5968551 Orally administrable opioid formulations having extended duration of effect 260 1995
5958459 Opioid formulations having extended controlled released 170 1995
5656295 Controlled release oxycodone compositions 226 1996
5681585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 144 1996
5672360 Method of treating pain by administering 24 hour oral opioid formulations 238 1996
6143322 Method of treating humans with opioid formulations having extended controlled release 173 1997
5958452 Extruded orally administrable opioid formulations 224 1997
5968547 Method of providing sustained analgesia with buprenorphine 112 1997
6077533 Powder-layered oral dosage forms 86 1998
6228863 Method of preventing abuse of opioid dosage forms 215 1998
* 6277384 Opioid agonist/antagonist combinations 136 1998
6103261 Opioid formulations having extended controlled release 166 1999
6335033 Melt-extrusion multiparticulates 130 1999
6261599 Melt-extruded orally administrable opioid formulations 178 1999
6294195 Orally administrable opioid formulations having extended duration of effect 153 1999
6375957 Opioid agonist/opioid antagonist/acetaminophen combinations 211 2000
6696088 Tamper-resistant oral opioid agonist formulations 164 2001
6716449 Controlled-release compositions containing opioid agonist and antagonist 114 2001
* 6475494 Opioid agonist/antagonist combinations 119 2001
2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone 73 2002
2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist 72 2002
* 6696066 Opioid agonist/antagonist combinations 161 2002
2003/0229,111 Naltrexone hydrochloride compositions 35 2003
2004/0186,121 Tamper-resistant oral opioid agonist formulations 60 2003
* 7172767 Opioid agonist / antagonist combinations 100 2003
2006/0182,801 Sequestered antagonist formulations 62 2006
* 7419686 Opioid agonist/antagonist combinations 61 2006
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (2)
4844909 Controlled release hydromorphone composition 170 1987
4844910 Spheroids 70 1987
 
McGinnis; Carolyn (1)
4608376 Opiate agonists and antagonists 70 1982
 
AMINOTEK SCIENCES, INC. A CORP. OF NEW JERSEY (1)
5256669 Methods and compositions for treating acute or chronic pain and drug addiction 78 1992
 
University of Kentucky Research Foundation (1)
4464378 Method of administering narcotic antagonists and analgesics and novel dosage forms containing same 211 1981
 
The United States of America as represented by the Secretary of the Army (1)
5834477 Opiate analgesic formulation with improved safety 61 1994
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (2)
5472943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists 132 1993
5585348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 97 1993
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (2)
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GENERAL ELECTRIC COMPANY (1)
5226331 Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream 48 1991
 
RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
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ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (10)
* 5512578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists 120 1994
5624932 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 70 1995
* 5580876 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 110 1995
5767125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 106 1996
6096756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 119 1998
6194382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 70 1999
2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS 51 1999
6362194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 61 2000
6395705 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 66 2001
6765010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 59 2002
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
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REGENTS OF THE UNIVERSITY OF MINNESOTA (6)
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4730048 Gut-selective opiates 107 1985
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5457208 Kappa opioid receptor antagonists 92 1993
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
RECRO GAINESVILLE LLC (3)
9132096 Abuse resistant pharmaceutical compositions 1 2014
9486451 Abuse resistant pharmaceutical compositions 0 2015
9452163 Abuse resistant pharmaceutical compositions 0 2015
 
PURDUE PHARMA L.P. (26)
8518925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 6 2005
9101625 Buprenorphine-wafer for drug substitution therapy 0 2007
8987290 Use of opioid formulations in needle-less drug delivery devices 0 2007
* 2010/0056,554 USE OF OPIOID FORMULATIONS IN NEEDLE-LESS DRUG DELIVERY DEVICES 0 2007
9271940 Immediate release pharmaceutical compositions comprising oxycodone and naloxone 0 2010
* 8105631 Opioid agonist/antagonist combinations 36 2010
8673355 Opioid agonist/antagonist combinations 11 2011
8846090 Matrix for sustained, invariant and independent release of active compounds 12 2012
8822487 Opioid agonist/opioid antagonist/acetaminophen combinations 11 2012
8846091 Matrix for sustained, invariant and independent release of active compounds 11 2013
9084729 Abuse-resistant controlled-release opioid dosage form 2 2013
8969369 Abuse-resistant controlled-release opioid dosage form 12 2013
9056051 Abuse-resistant controlled-release opioid dosage form 4 2014
9205082 Opioid agonist/antagonist combinations 0 2014
9555000 Pharmaceutical preparation containing oxycodone and naloxone 0 2014
9474750 Opioid agonist/opioid antagonist/acetaminophen combinations 0 2014
8936808 Opioid agonist/opioid antagonist/acetaminophen combinations 2 2014
8932630 Opioid agonist/antagonist combinations 2 2014
9168252 Abuse-resistant controlled-release opioid dosage form 2 2015
9161937 Abuse-resistant controlled-release opioid dosage form 2 2015
9283216 Abuse-resistant controlled-release opioid dosage form 0 2015
9283221 Abuse-resistant controlled-release opioid dosage form 0 2015
9358230 Abuse-resistant controlled-release opioid dosage form 0 2016
9345701 Abuse-resistant controlled-release opioid dosage form 0 2016
9511066 Abuse-resistant controlled-release opioid dosage form 0 2016
9480685 Abuse-resistant controlled-release opioid dosage form 0 2016
 
QRxPharma Ltd. (1)
* 8933092 Methods and compositions comprising sequential administration opioid receptor agonists 1 2012
 
RHODES PHARMACEUTICALS L.P. (1)
9370512 Buprenorphine-wafer for drug substitution therapy 0 2015
 
EGALET LTD. (7)
8877241 Morphine controlled release system 2 2004
9005660 Immediate release composition resistant to abuse by intake of alcohol 2 2010
9023394 Formulations and methods for the controlled release of active drug substances 1 2013
8808745 Morphine polymer release system 6 2013
9044402 Abuse-deterrent pharmaceutical compositions for controlled release 1 2014
9375428 Morphine controlled release system 0 2014
9358295 Immediate release composition resistant to abuse by intake of alcohol 1 2015
* Cited By Examiner

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