US Patent No: 7,749,542

Number of patents in Portfolio can not be more than 2000

Opioid agonist/antagonist combinations

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
PURDUE PHARMA L.P.STAMFORD, CT390

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colucci, Robert D Newtown, US 20 1442
Kaiko, Robert F Weston, US 45 2360

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
5,376,662 Method of attenuating nerve injury induced pain 71 1993
2004/0092,542 Tamper-resistant oral opioid agonist formulations 50 2003
2005/0095,291 Tamper-resistant oral opioid agonist formulations 62 2003
2005/0181,046 Tamper-resistant oral opioid agonist formulations 51 2003
2006/0039,970 Tamper-resistant oral opioid agonist formulations 37 2003
 
NOVA PHARMACEUTICAL CORPORATION (2)
4,760,069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 85 1985
4,889,860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 90 1987
 
The Lynx Project Limited (1)
6,310,072 Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist 67 1997
 
VIRGINIA COMMONWEALTH UNIVERSITY (4)
5,352,683 Method for the treatment of chronic pain 117 1993
5,321,012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance 177 1993
5,502,058 Method for the treatment of pain 157 1994
5,556,838 Inhibiting the development of tolerance to and/or dependence on an addictive substance 159 1994
 
The United States of America as represented by the Department of Health and Human Services (1)
5,225,440 Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase 77 1991
 
Eli Lilly and Company (1)
5,998,434 Composition for treating pain 64 1998
 
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (1)
4,803,208 Opiate agonists and antagonists 73 1985
 
ICN HUNGARY RT. (1)
5,317,022 Pharmaceutical composition and use 76 1992
 
G. D. Searle & Co. (1)
5,616,601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation 154 1995
 
SCULLY SCOTT MURPHY & PRESSER, PC (1)
5,426,112 Growth regulation and related applications of opioid antagonists 126 1993
 
BAKER NORTON PHARMACEUTICALS, INC. (1)
4,873,076 Method of safely providing anesthesia or conscious sedation 84 1989
 
OMEROS CORPORATION (2)
5,858,017 Urologic irrigation solution and method for inhibition of pain, inflammation and spasm 128 1996
5,860,950 Arthroscopic irrigation solution and method for inhibition of pain and inflammation 117 1996
 
COLMAN PRODUCTS LIMITED (1)
4,935,428 Treating opiate dependence 98 1988
 
PEPTECH LIMITED (1)
5,534,492 Muramyl peptide for the treatment of toxicity 66 1995
 
The Rockefeller University (3)
4,987,136 Method for controlling gastrointestinal dysmotility 133 1986
4,769,372 Method of treating patients suffering from chronic pain or chronic cough 137 1986
4,785,000 Method of treating patients suffering from chronic pain or chronic cough 99 1987
 
ADIR ET COMPAGNIE (1)
5,130,311 Oxazolopyridine compounds, compositions and use 83 1991
 
Schaap; Robert J. (2)
5,316,759 Agonist-antagonist combination to reduce the use of nicotine and other drugs 96 1992
5,574,052 Agonist-antagonist combination to reduce the use of nicotine and other drugs 154 1994
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
4,451,470 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans 85 1982
5,593,994 Prostaglandin synthase inhibitors 101 1994
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,457,933 Prevention of analgesic abuse 156 1981
 
DynaGen, Inc. (1)
5,486,362 Controlled, sustained release delivery system for treating drug dependency 129 1993
 
MERCK SHARP & DOHME LTD. (1)
5,880,132 Tachykinin antagonist and an opioid analgesic effective at treating pain or nociception 77 1997
 
Warner-Lambert Company (1)
5,149,538 Misuse-resistive transdermal opioid dosage form 208 1991
 
The University of Chicago (4)
4,719,215 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 111 1986
4,861,781 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 105 1987
5,102,887 Method for reducing emesis and nausea induced by the administration of an emesis causing agent 104 1990
5,972,954 Use of methylnaltrexone and related compounds 122 1997
 
United Biomedical, Inc. (1)
5,633,259 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 70 1995
 
University of Oregon (1)
5,514,680 Glycine receptor antagonists and the use thereof 102 1993
 
MERCK FROSST COMPANY (1)
5,474,995 Phenyl heterocycles as cox-2 inhibitors 193 1994
 
CONTRAL CLINICS OY (3)
4,882,335 Method for treating alcohol-drinking response 96 1988
5,096,715 Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist 79 1989
5,086,058 Method for treating alcoholism with nalmefene 92 1990
 
ALZA CORPORATION (4)
4,573,995 Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine 169 1984
5,236,714 Abusable substance dosage form having reduced abuse potential 132 1988
5,460,826 Morphine therapy 133 1994
5,866,164 Composition and dosage form comprising opioid antagonist 204 1997
 
YOUNG, JACQUELINE, MS. (1)
5,356,900 Method of treating chronic herpes virus infections using an opiate receptor antagonist 74 1993
 
SIMON, DAVID L. (1)
6,103,258 Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics 63 1998
 
MERCK FROSST CANADA LTD. (10)
5,409,944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase 106 1993
5,604,260 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 123 1993
5,436,265 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents 124 1993
5,521,213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 131 1994
5,552,422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents 142 1995
5,536,752 Phenyl heterocycles as COX-2 inhibitors 119 1995
5,550,142 Phenyl heterocycles as cox-2 inhibitors 123 1995
5,510,368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs 124 1995
5,604,253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 111 1995
5,639,780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 111 1995
 
EURO-CELTIQUE S.A. (36)
4,366,310 Controlled release compositions 85 1980
4,443,428 Extended action controlled release compositions 138 1982
4,940,587 Oral pharmaceutical composition through mucosa 125 1986
4,844,907 Pharmaceutical composition comprising analgesic and anti-inflammatory agent 151 1986
4,834,965 Controlled release pharmaceutical composition 111 1987
4,867,985 Spheroids 104 1988
5,071,646 Pharmaceutical ion exchange resin composition 146 1989
5,091,189 Controlled release dosage forms having a defined water content 59 1991
5,215,758 Controlled release matrix suppository for pharmaceuticals 120 1991
5,324,351 Aqueous dispersions of zein and preparation thereof 135 1992
5,356,467 Controlled release coatings derived from aqueous dispersions of zein 213 1993
5,500,227 Immediate release tablet cores of insoluble drugs having sustained-release coating 192 1993
5,622,722 Spheroid formulation 58 1994
5,508,043 Controlled release matrix for pharmaceuticals 77 1995
5,670,172 Pharmaceutical spheroid formulation 99 1995
6,024,982 Immediate release tablet cores of insoluble drugs having sustained-release coating 138 1995
5,811,126 Controlled release matrix for pharmaceuticals 122 1995
5,763,452 Pharmaceutical compositions and usages 57 1996
5,849,240 Method of preparing sustained release pharmaceutical compositions 171 1996
5,891,471 Pharmaceutical multiparticulates 151 1996
5,601,845 Pharmaceutical spheroid formulation 104 1996
5,843,480 Controlled release diamorphine formulation 122 1996
5,879,705 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions 158 1997
5,908,848 Synergistic composition of codine and ibuprofen to treat arthritis 59 1997
5,942,241 Formulations and methods for providing prolonged local anesthesia 166 1997
6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same 92 1997
5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions 162 1997
6,077,532 Pharmaceutical ion exchange resin composition 66 1998
6,306,438 Stabilized sustained release tramadol formulations 93 1998
6,399,096 Pharmaceutical formulation 102 1998
6,143,328 Sustained release compositions and a method of preparing pharmaceutical compositions 76 1999
6,162,467 Sustained release compositions and a method of preparing pharmaceutical compositions 129 1999
6,210,714 Immediate release tablet cores of acetaminophen having sustained-release coating 103 2000
6,387,404 Immediate release tablet cores of insoluble drugs having sustained-release coating 116 2001
6,716,449 Controlled-release compositions containing opioid agonist and antagonist 112 2001
6,627,635 Method of preventing abuse of opioid dosage forms 137 2001
 
PURDUE PHARMA L.P. (39)
4,828,836 Controlled release pharmaceutical composition 219 1987
4,834,985 Controlled release pharmaceutical composition 231 1987
4,990,341 Controlled release hydromorphone composition 175 1989
5,266,331 Controlled release oxycodone compositions 244 1991
5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 255 1991
5,286,493 Stabilized controlled release formulations having acrylic polymer coating 251 1992
5,549,912 Controlled release oxycodone compositions 237 1993
5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 237 1993
5,478,577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level 248 1993
5,411,745 Powder-layered morphine sulfate formulations 154 1994
5,965,161 Extruded multi-particulates 186 1994
5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 515 1995
5,508,042 Controlled release oxycodone compositions 257 1995
5,968,551 Orally administrable opioid formulations having extended duration of effect 255 1995
5,958,459 Opioid formulations having extended controlled released 167 1995
5,656,295 Controlled release oxycodone compositions 222 1996
5,681,585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 142 1996
5,672,360 Method of treating pain by administering 24 hour oral opioid formulations 234 1996
6,143,322 Method of treating humans with opioid formulations having extended controlled release 170 1997
5,958,452 Extruded orally administrable opioid formulations 219 1997
5,968,547 Method of providing sustained analgesia with buprenorphine 110 1997
6,077,533 Powder-layered oral dosage forms 85 1998
6,228,863 Method of preventing abuse of opioid dosage forms 211 1998
* 6,277,384 Opioid agonist/antagonist combinations 135 1998
6,103,261 Opioid formulations having extended controlled release 164 1999
6,335,033 Melt-extrusion multiparticulates 129 1999
6,261,599 Melt-extruded orally administrable opioid formulations 175 1999
6,294,195 Orally administrable opioid formulations having extended duration of effect 151 1999
6,375,957 Opioid agonist/opioid antagonist/acetaminophen combinations 206 2000
6,696,088 Tamper-resistant oral opioid agonist formulations 159 2001
* 6,475,494 Opioid agonist/antagonist combinations 118 2001
2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone 72 2002
2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist 70 2002
* 6,696,066 Opioid agonist/antagonist combinations 160 2002
2003/0229,111 Naltrexone hydrochloride compositions 34 2003
2004/0186,121 Tamper-resistant oral opioid agonist formulations 58 2003
* 7,172,767 Opioid agonist / antagonist combinations 99 2003
2006/0182,801 Sequestered antagonist formulations 60 2006
* 7,419,686 Opioid agonist/antagonist combinations 60 2006
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (2)
4,844,909 Controlled release hydromorphone composition 167 1987
4,844,910 Spheroids 69 1987
 
McGinnis; Carolyn (1)
4,608,376 Opiate agonists and antagonists 69 1982
 
AMINOTEK SCIENCES, INC. A CORP. OF NEW JERSEY (1)
5,256,669 Methods and compositions for treating acute or chronic pain and drug addiction 77 1992
 
University of Kentucky Research Foundation (1)
4,464,378 Method of administering narcotic antagonists and analgesics and novel dosage forms containing same 208 1981
 
The United States of America as represented by the Secretary of the Army (1)
5,834,477 Opiate analgesic formulation with improved safety 60 1994
 
GENERAL ELECTRIC COMPANY (1)
5,226,331 Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream 48 1991
 
RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
4,806,341 Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration 166 1986
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (12)
5,472,943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists 130 1993
5,585,348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 96 1993
* 5,512,578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists 119 1994
5,624,932 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 69 1995
* 5,580,876 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 108 1995
5,767,125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 105 1996
6,096,756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 115 1998
6,194,382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 69 1999
2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS 50 1999
6,362,194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 60 2000
6,395,705 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 65 2001
6,765,010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 58 2002
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (2)
4,582,835 Analgesic compositions 143 1984
4,661,492 Analgesic compositions 112 1985
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,806,543 Method and compositions for reducing neurotoxic injury 96 1986
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (6)
4,401,672 Non-addictive narcotic antitussive preparation 81 1981
4,730,048 Gut-selective opiates 106 1985
5,352,680 Delta opioid receptor antagonists to block opioid agonist tolerance and dependence 128 1992
5,457,208 Kappa opioid receptor antagonists 91 1993
5,578,725 Delta opioid receptor antagonists 74 1995
5,780,479 Use of opioid antagonists to treat impulse-control disorders 69 1997
 
The McLean Hospital Corporation (1)
5,075,341 Treatment for cocaine abuse 156 1989
 
Ortho-McNeil Pharmaceutical, Inc. (1)
5,336,691 Composition comprising a tramadol material and acetaminophen and its use 100 1992
 
NAPP PHARMACEUTICAL GROUP LIMITED (3)
5,591,452 Controlled release formulation 105 1994
6,326,027 Controlled release formulation 99 1995
6,254,887 Controlled release tramadol 105 1996
 
ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (1)
5,869,097 Method of therapy comprising an osmotic caplet 90 1992
 
PURDUE PHARMA COMPANY, THE (2)
4,861,598 Controlled release bases for pharmaceuticals 223 1986
4,970,075 Controlled release bases for pharmaceuticals 189 1989
 
DUPONT MERCK PHARMACEUTICAL COMPANY, THE (1)
4,722,928 N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes 40 1985
 
PUREUE PHARMA L.P. (1)
4,834,984 Controlled release dihydrocodeine composition 160 1987
 
LIFESHIELD SCIENCES LLC (1)
2004/0158,312 Braided endoluminal device having tapered filaments 22 2003
 
BASF AKTIENGESELLSCHAFT (2)
4,806,558 Diarylacetylenes and their use in treating acne 71 1985
4,957,681 Preparation of pharmaceutical mixtures 134 1989
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
RECRO GAINESVILLE LLC (3)
9,132,096 Abuse resistant pharmaceutical compositions 1 2014
9,486,451 Abuse resistant pharmaceutical compositions 0 2015
9,452,163 Abuse resistant pharmaceutical compositions 0 2015
 
PURDUE PHARMA L.P. (26)
8,518,925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 6 2005
9,101,625 Buprenorphine-wafer for drug substitution therapy 0 2007
8,987,290 Use of opioid formulations in needle-less drug delivery devices 0 2007
* 2010/0056,554 USE OF OPIOID FORMULATIONS IN NEEDLE-LESS DRUG DELIVERY DEVICES 0 2007
9,271,940 Immediate release pharmaceutical compositions comprising oxycodone and naloxone 0 2010
* 8,105,631 Opioid agonist/antagonist combinations 35 2010
8,673,355 Opioid agonist/antagonist combinations 11 2011
8,846,090 Matrix for sustained, invariant and independent release of active compounds 12 2012
8,822,487 Opioid agonist/opioid antagonist/acetaminophen combinations 11 2012
8,846,091 Matrix for sustained, invariant and independent release of active compounds 11 2013
9,084,729 Abuse-resistant controlled-release opioid dosage form 2 2013
8,969,369 Abuse-resistant controlled-release opioid dosage form 12 2013
9,056,051 Abuse-resistant controlled-release opioid dosage form 4 2014
9,205,082 Opioid agonist/antagonist combinations 0 2014
9,474,750 Opioid agonist/opioid antagonist/acetaminophen combinations 0 2014
8,936,808 Opioid agonist/opioid antagonist/acetaminophen combinations 2 2014
8,932,630 Opioid agonist/antagonist combinations 2 2014
9,168,252 Abuse-resistant controlled-release opioid dosage form 2 2015
9,161,937 Abuse-resistant controlled-release opioid dosage form 2 2015
9,370,512 Buprenorphine-wafer for drug substitution therapy 0 2015
9,283,216 Abuse-resistant controlled-release opioid dosage form 0 2015
9,283,221 Abuse-resistant controlled-release opioid dosage form 0 2015
9,358,230 Abuse-resistant controlled-release opioid dosage form 0 2016
9,345,701 Abuse-resistant controlled-release opioid dosage form 0 2016
9,511,066 Abuse-resistant controlled-release opioid dosage form 0 2016
9,480,685 Abuse-resistant controlled-release opioid dosage form 0 2016
 
QRxPharma Ltd. (1)
* 8,933,092 Methods and compositions comprising sequential administration opioid receptor agonists 1 2012
 
EGALET LTD. (7)
8,877,241 Morphine controlled release system 2 2004
9,005,660 Immediate release composition resistant to abuse by intake of alcohol 2 2010
9,023,394 Formulations and methods for the controlled release of active drug substances 1 2013
8,808,745 Morphine polymer release system 5 2013
9,044,402 Abuse-deterrent pharmaceutical compositions for controlled release 1 2014
9,375,428 Morphine controlled release system 0 2014
9,358,295 Immediate release composition resistant to abuse by intake of alcohol 1 2015
* Cited By Examiner

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Jan 6, 2018
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jan 6, 2022
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00