US Patent No: 7,749,542

Number of patents in Portfolio can not be more than 2000

Opioid agonist/antagonist combinations

ALSO PUBLISHED AS: 20080292694
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Abstract

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The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PURDUE PHARMA L.P.STAMFORD, CT287

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colucci, Robert D Newtown, CT 28 878
Kaiko, Robert F Weston, CT 51 1434

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
5,376,662 Method of attenuating nerve injury induced pain 54 1993
2004/0092,542 Tamper-resistant oral opioid agonist formulations 35 2003
2005/0095,291 Tamper-resistant oral opioid agonist formulations 46 2003
2005/0181,046 Tamper-resistant oral opioid agonist formulations 33 2003
2006/0039,970 Tamper-resistant oral opioid agonist formulations 24 2003
 
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4,760,069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 67 1985
4,889,860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 70 1987
 
The Lynx Project Limited (1)
6,310,072 Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist 49 1997
 
VIRGINIA COMMONWEALTH UNIVERSITY (4)
5,352,683 Method for the treatment of chronic pain 86 1993
5,321,012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance 128 1993
5,502,058 Method for the treatment of pain 111 1994
5,556,838 Inhibiting the development of tolerance to and/or dependence on an addictive substance 117 1994
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,225,440 Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase 59 1991
 
Eli Lilly and Company (1)
5,998,434 Composition for treating pain 47 1998
 
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (1)
4,803,208 Opiate agonists and antagonists 56 1985
 
ICN HUNGARY RT. (1)
5,317,022 Pharmaceutical composition and use 59 1992
 
G. D. Searle & Co. (1)
5,616,601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation 121 1995
 
SCULLY SCOTT MURPHY & PRESSER, PC (1)
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BAKER NORTON PHARMACEUTICALS, INC. (1)
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OMEROS CORPORATION (2)
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COLMAN PRODUCTS LIMITED (1)
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PEPTECH LIMITED (1)
5,534,492 Muramyl peptide for the treatment of toxicity 49 1995
 
The Rockefeller University (3)
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Schaap; Robert J. (2)
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5,574,052 Agonist-antagonist combination to reduce the use of nicotine and other drugs 121 1994
 
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DYNAGEN, INC. (1)
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MERCK SHARP & DOHME LTD. (1)
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Warner-Lambert Company (1)
5,149,538 Misuse-resistive transdermal opioid dosage form 148 1991
 
UNIVERSITY OF CHICAGO, THE (4)
4,719,215 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 87 1986
4,861,781 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 82 1987
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5,972,954 Use of methylnaltrexone and related compounds 98 1997
 
United Biomedical, Inc. (1)
5,633,259 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 51 1995
 
OREGON, UNIVERSITY OF (1)
5,514,680 Glycine receptor antagonists and the use thereof 70 1993
 
MERCK FROSST COMPANY (1)
5,474,995 Phenyl heterocycles as cox-2 inhibitors 154 1994
 
CONTRAL CLINICS OY (3)
4,882,335 Method for treating alcohol-drinking response 76 1988
5,096,715 Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist 59 1989
5,086,058 Method for treating alcoholism with nalmefene 74 1990
 
ALZA CORPORATION (4)
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5,460,826 Morphine therapy 96 1994
5,866,164 Composition and dosage form comprising opioid antagonist 125 1997
 
YOUNG, JACQUELINE, MS. (1)
5,356,900 Method of treating chronic herpes virus infections using an opiate receptor antagonist 56 1993
 
SIMON, DAVID L. (1)
6,103,258 Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics 46 1998
 
MERCK FROSST CANADA LTD. (10)
5,409,944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase 74 1993
5,604,260 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 86 1993
5,436,265 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents 90 1993
5,521,213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 96 1994
5,552,422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents 104 1995
5,536,752 Phenyl heterocycles as COX-2 inhibitors 82 1995
5,550,142 Phenyl heterocycles as cox-2 inhibitors 88 1995
5,510,368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs 92 1995
5,604,253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 75 1995
5,639,780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 74 1995
 
EURO-CELTIQUE S.A. (36)
4,366,310 Controlled release compositions 51 1980
4,443,428 Extended action controlled release compositions 91 1982
4,940,587 Oral pharmaceutical composition through mucosa 106 1986
4,844,907 Pharmaceutical composition comprising analgesic and anti-inflammatory agent 124 1986
4,834,965 Controlled release pharmaceutical composition 83 1987
4,867,985 Spheroids 84 1988
5,071,646 Pharmaceutical ion exchange resin composition 111 1989
5,091,189 Controlled release dosage forms having a defined water content 43 1991
5,215,758 Controlled release matrix suppository for pharmaceuticals 81 1991
5,324,351 Aqueous dispersions of zein and preparation thereof 93 1992
5,356,467 Controlled release coatings derived from aqueous dispersions of zein 142 1993
5,500,227 Immediate release tablet cores of insoluble drugs having sustained-release coating 140 1993
5,622,722 Spheroid formulation 42 1994
5,508,043 Controlled release matrix for pharmaceuticals 50 1995
5,670,172 Pharmaceutical spheroid formulation 70 1995
6,024,982 Immediate release tablet cores of insoluble drugs having sustained-release coating 93 1995
5,811,126 Controlled release matrix for pharmaceuticals 76 1995
5,763,452 Pharmaceutical compositions and usages 41 1996
5,849,240 Method of preparing sustained release pharmaceutical compositions 108 1996
5,891,471 Pharmaceutical multiparticulates 96 1996
5,601,845 Pharmaceutical spheroid formulation 86 1996
5,843,480 Controlled release diamorphine formulation 76 1996
5,879,705 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions 106 1997
5,908,848 Synergistic composition of codine and ibuprofen to treat arthritis 43 1997
5,942,241 Formulations and methods for providing prolonged local anesthesia 124 1997
6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same 65 1997
5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions 105 1997
6,077,532 Pharmaceutical ion exchange resin composition 49 1998
6,306,438 Stabilized sustained release tramadol formulations 66 1998
6,399,096 Pharmaceutical formulation 68 1998
6,143,328 Sustained release compositions and a method of preparing pharmaceutical compositions 53 1999
6,162,467 Sustained release compositions and a method of preparing pharmaceutical compositions 79 1999
6,210,714 Immediate release tablet cores of acetaminophen having sustained-release coating 71 2000
6,387,404 Immediate release tablet cores of insoluble drugs having sustained-release coating 76 2001
6,716,449 Controlled-release compositions containing opioid agonist and antagonist 74 2001
6,627,635 Method of preventing abuse of opioid dosage forms 85 2001
 
PURDUE PHARMA L.P. (39)
4,828,836 Controlled release pharmaceutical composition 178 1987
4,834,985 Controlled release pharmaceutical composition 195 1987
4,990,341 Controlled release hydromorphone composition 124 1989
5,266,331 Controlled release oxycodone compositions 151 1991
5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 186 1991
5,286,493 Stabilized controlled release formulations having acrylic polymer coating 181 1992
5,549,912 Controlled release oxycodone compositions 144 1993
5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 165 1993
5,478,577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level 162 1993
5,411,745 Powder-layered morphine sulfate formulations 100 1994
5,965,161 Extruded multi-particulates 115 1994
5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 369 1995
5,508,042 Controlled release oxycodone compositions 151 1995
5,968,551 Orally administrable opioid formulations having extended duration of effect 160 1995
5,958,459 Opioid formulations having extended controlled released 96 1995
5,656,295 Controlled release oxycodone compositions 130 1996
5,681,585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 93 1996
5,672,360 Method of treating pain by administering 24 hour oral opioid formulations 159 1996
6,143,322 Method of treating humans with opioid formulations having extended controlled release 110 1997
5,958,452 Extruded orally administrable opioid formulations 144 1997
5,968,547 Method of providing sustained analgesia with buprenorphine 83 1997
6,077,533 Powder-layered oral dosage forms 60 1998
6,228,863 Method of preventing abuse of opioid dosage forms 135 1998
* 6,277,384 Opioid agonist/antagonist combinations 97 1998
6,103,261 Opioid formulations having extended controlled release 105 1999
6,335,033 Melt-extrusion multiparticulates 76 1999
6,261,599 Melt-extruded orally administrable opioid formulations 119 1999
6,294,195 Orally administrable opioid formulations having extended duration of effect 107 1999
6,375,957 Opioid agonist/opioid antagonist/acetaminophen combinations 130 2000
6,696,088 Tamper-resistant oral opioid agonist formulations 103 2001
* 6,475,494 Opioid agonist/antagonist combinations 74 2001
2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone 50 2002
2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist 49 2002
* 6,696,066 Opioid agonist/antagonist combinations 101 2002
2003/0229,111 Naltrexone hydrochloride compositions 17 2003
2004/0186,121 Tamper-resistant oral opioid agonist formulations 41 2003
* 7,172,767 Opioid agonist / antagonist combinations 57 2003
2006/0182,801 Sequestered antagonist formulations 37 2006
* 7,419,686 Opioid agonist/antagonist combinations 33 2006
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (2)
4,844,909 Controlled release hydromorphone composition 118 1987
4,844,910 Spheroids 52 1987
 
McGinnis; Carolyn (1)
4,608,376 Opiate agonists and antagonists 52 1982
 
Aminotek Sciences, Inc. (1)
5,256,669 Methods and compositions for treating acute or chronic pain and drug addiction 60 1992
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
4,464,378 Method of administering narcotic antagonists and analgesics and novel dosage forms containing same 154 1981
 
The United States of America as represented by the Secretary of the Army (1)
5,834,477 Opiate analgesic formulation with improved safety 42 1994
 
GENERAL ELECTRIC COMPANY (1)
5,226,331 Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream 43 1991
 
RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
4,806,341 Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration 118 1986
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (12)
5,472,943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists 90 1993
5,585,348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 75 1993
* 5,512,578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists 96 1994
5,624,932 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 49 1995
* 5,580,876 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 79 1995
5,767,125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 81 1996
6,096,756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 80 1998
6,194,382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 49 1999
2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS 23 1999
6,362,194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 39 2000
6,395,705 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 46 2001
6,765,010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 40 2002
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (2)
4,582,835 Analgesic compositions 110 1984
4,661,492 Analgesic compositions 77 1985
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,806,543 Method and compositions for reducing neurotoxic injury 78 1986
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (6)
4,401,672 Non-addictive narcotic antitussive preparation 62 1981
4,730,048 Gut-selective opiates 83 1985
5,352,680 Delta opioid receptor antagonists to block opioid agonist tolerance and dependence 103 1992
5,457,208 Kappa opioid receptor antagonists 74 1993
5,578,725 Delta opioid receptor antagonists 56 1995
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THE MCLEAN HOSPITAL CORPORATION (1)
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5,336,691 Composition comprising a tramadol material and acetaminophen and its use 77 1992
 
NAPP PHARMACEUTICAL GROUP LIMITED (3)
5,591,452 Controlled release formulation 87 1994
6,326,027 Controlled release formulation 78 1995
6,254,887 Controlled release tramadol 74 1996
 
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PURDUE PHARMA COMPANY, THE (2)
4,861,598 Controlled release bases for pharmaceuticals 151 1986
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DUPONT MERCK PHARMACEUTICAL COMPANY, THE (1)
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PUREUE PHARMA L.P. (1)
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LIFESHIELD SCIENCES LLC (1)
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BASF AKTIENGESELLSCHAFT (2)
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
9,005,660 Immediate release composition resistant to abuse by intake of alcohol 0 2010
 
PURDUE PHARMA L.P. (10)
8,518,925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 1 2005
8,987,290 Use of opioid formulations in needle-less drug delivery devices 0 2007
* 8,105,631 Opioid agonist/antagonist combinations 13 2010
8,673,355 Opioid agonist/antagonist combinations 0 2011
8,846,090 Matrix for sustained, invariant and independent release of active compounds 0 2012
8,822,487 Opioid agonist/opioid antagonist/acetaminophen combinations 0 2012
8,846,091 Matrix for sustained, invariant and independent release of active compounds 0 2013
8,969,369 Abuse-resistant controlled-release opioid dosage form 0 2013
8,936,808 Opioid agonist/opioid antagonist/acetaminophen combinations 0 2014
8,932,630 Opioid agonist/antagonist combinations 0 2014
 
QRXPHARMA LTD. (1)
* 8,933,092 Methods and compositions comprising sequential administration opioid receptor agonists 0 2012
 
EGALET LTD. (2)
8,877,241 Morphine controlled release system 0 2004
8,808,745 Morphine polymer release system 1 2013
* Cited By Examiner

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