US Patent No: 7,749,542
Number of patents in Portfolio can not be more than 2000
Opioid agonist/antagonist combinations
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Jul 6, 2010
Issued date -
Jul 28, 2008
filing date -
12/220,760
serial no -
In Force
status
Importance
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Abstract
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
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First Claim
Related Publications
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International Classification(s)
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- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,828,836 Controlled release pharmaceutical composition | 128 | 1987 | |
| 4,834,985 Controlled release pharmaceutical composition | 160 | 1987 | |
| 4,990,341 Controlled release hydromorphone composition | 84 | 1989 | |
| 5,266,331 Controlled release oxycodone compositions | 92 | 1991 | |
| 5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer | 124 | 1991 | |
| 5,286,493 Stabilized controlled release formulations having acrylic polymer coating | 125 | 1992 | |
| 5,549,912 Controlled release oxycodone compositions | 81 | 1993 | |
| 5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose | 109 | 1993 | |
| 5,478,577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level | 82 | 1993 | |
| 5,411,745 Powder-layered morphine sulfate formulations | 60 | 1994 | |
| 5,965,161 Extruded multi-particulates | 61 | 1994 | |
| 5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers | 237 | 1995 | |
| 5,508,042 Controlled release oxycodone compositions | 81 | 1995 | |
| 5,968,551 Orally administrable opioid formulations having extended duration of effect | 89 | 1995 | |
| 5,958,459 Opioid formulations having extended controlled released | 52 | 1995 | |
| 5,656,295 Controlled release oxycodone compositions | 67 | 1996 | |
| 5,681,585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer | 56 | 1996 | |
| 5,672,360 Method of treating pain by administering 24 hour oral opioid formulations | 90 | 1996 | |
| 6,143,322 Method of treating humans with opioid formulations having extended controlled release | 63 | 1997 | |
| 5,958,452 Extruded orally administrable opioid formulations | 78 | 1997 | |
| 5,968,547 Method of providing sustained analgesia with buprenorphine | 46 | 1997 | |
| 6,077,533 Powder-layered oral dosage forms | 36 | 1998 | |
| 6,228,863 Method of preventing abuse of opioid dosage forms | 70 | 1998 | |
| 6,277,384 Opioid agonist/antagonist combinations | 51 | 1998 | |
| 6,103,261 Opioid formulations having extended controlled release | 52 | 1999 | |
| 6,335,033 Melt-extrusion multiparticulates | 41 | 1999 | |
| 6,261,599 Melt-extruded orally administrable opioid formulations | 65 | 1999 | |
| 6,294,195 Orally administrable opioid formulations having extended duration of effect | 64 | 1999 | |
| 6,375,957 Opioid agonist/opioid antagonist/acetaminophen combinations | 62 | 2000 | |
| 6,696,088 Tamper-resistant oral opioid agonist formulations | 48 | 2001 | |
| 6,475,494 Opioid agonist/antagonist combinations | 38 | 2001 | |
| 2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone | 24 | 2002 | |
| 2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist | 23 | 2002 | |
| 6,696,066 Opioid agonist/antagonist combinations | 37 | 2002 | |
| 2003/0229,111 Naltrexone hydrochloride compositions | 9 | 2003 | |
| 2004/0186,121 Tamper-resistant oral opioid agonist formulations | 14 | 2003 | |
| 7,172,767 Opioid agonist / antagonist combinations | 20 | 2003 | |
| 2006/0182,801 Sequestered antagonist formulations | 18 | 2006 | |
| 7,419,686 Opioid agonist/antagonist combinations | 11 | 2006 | |
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| 4,366,310 Controlled release compositions | 27 | 1980 | |
| 4,940,587 Oral pharmaceutical composition through mucosa | 71 | 1986 | |
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| 4,867,985 Spheroids | 63 | 1988 | |
| 5,071,646 Pharmaceutical ion exchange resin composition | 73 | 1989 | |
| 5,091,189 Controlled release dosage forms having a defined water content | 24 | 1991 | |
| 5,215,758 Controlled release matrix suppository for pharmaceuticals | 54 | 1991 | |
| 5,324,351 Aqueous dispersions of zein and preparation thereof | 62 | 1992 | |
| 5,356,467 Controlled release coatings derived from aqueous dispersions of zein | 93 | 1993 | |
| 5,500,227 Immediate release tablet cores of insoluble drugs having sustained-release coating | 93 | 1993 | |
| 5,622,722 Spheroid formulation | 24 | 1994 | |
| 5,508,043 Controlled release matrix for pharmaceuticals | 31 | 1995 | |
| 5,670,172 Pharmaceutical spheroid formulation | 44 | 1995 | |
| 6,024,982 Immediate release tablet cores of insoluble drugs having sustained-release coating | 53 | 1995 | |
| 5,811,126 Controlled release matrix for pharmaceuticals | 49 | 1995 | |
| 5,763,452 Pharmaceutical compositions and usages | 23 | 1996 | |
| 5,849,240 Method of preparing sustained release pharmaceutical compositions | 60 | 1996 | |
| 5,891,471 Pharmaceutical multiparticulates | 51 | 1996 | |
| 5,601,845 Pharmaceutical spheroid formulation | 55 | 1996 | |
| 5,843,480 Controlled release diamorphine formulation | 41 | 1996 | |
| 5,879,705 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions | 54 | 1997 | |
| 5,908,848 Synergistic composition of codine and ibuprofen to treat arthritis | 24 | 1997 | |
| 5,942,241 Formulations and methods for providing prolonged local anesthesia | 78 | 1997 | |
| 6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same | 39 | 1997 | |
| 5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions | 59 | 1997 | |
| 6,077,532 Pharmaceutical ion exchange resin composition | 30 | 1998 | |
| 6,306,438 Stabilized sustained release tramadol formulations | 38 | 1998 | |
| 6,399,096 Pharmaceutical formulation | 30 | 1998 | |
| 6,143,328 Sustained release compositions and a method of preparing pharmaceutical compositions | 27 | 1999 | |
| 6,162,467 Sustained release compositions and a method of preparing pharmaceutical compositions | 42 | 1999 | |
| 6,210,714 Immediate release tablet cores of acetaminophen having sustained-release coating | 34 | 2000 | |
| 6,387,404 Immediate release tablet cores of insoluble drugs having sustained-release coating | 34 | 2001 | |
| 6,716,449 Controlled-release compositions containing opioid agonist and antagonist | 38 | 2001 | |
| 6,627,635 Method of preventing abuse of opioid dosage forms | 42 | 2001 | |
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| 5,512,578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists | 63 | 1994 | |
| 5,624,932 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction | 29 | 1995 | |
| 5,767,125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists | 48 | 1996 | |
| 6,096,756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists | 35 | 1998 | |
| 2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS | 8 | 1999 | |
| 6,362,194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists | 16 | 2000 | |
| 6,395,705 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists | 22 | 2001 | |
| 6,765,010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects | 19 | 2002 | |
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| 4,200,098 Osmotic system with distribution zone for dispensing beneficial agent | 263 | 1978 | |
| 4,285,987 Process for manufacturing device with dispersion zone | 241 | 1979 | |
| 4,573,995 Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine | 103 | 1984 | |
| 5,236,714 Abusable substance dosage form having reduced abuse potential | 57 | 1988 | |
| 5,460,826 Morphine therapy | 60 | 1994 | |
| 5,866,164 Composition and dosage form comprising opioid antagonist | 69 | 1997 | |
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| 4,401,672 Non-addictive narcotic antitussive preparation | 41 | 1981 | |
| 4,730,048 Gut-selective opiates | 51 | 1985 | |
| 5,352,680 Delta opioid receptor antagonists to block opioid agonist tolerance and dependence | 67 | 1992 | |
| 5,457,208 Kappa opioid receptor antagonists | 52 | 1993 | |
| 5,578,725 Delta opioid receptor antagonists | 35 | 1995 | |
| 5,780,479 Use of opioid antagonists to treat impulse-control disorders | 29 | 1997 | |
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| 5,436,265 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents | 59 | 1993 | |
| 5,521,213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 | 70 | 1994 | |
| 5,536,752 Phenyl heterocycles as COX-2 inhibitors | 54 | 1995 | |
| 5,550,142 Phenyl heterocycles as cox-2 inhibitors | 61 | 1995 | |
| 5,639,780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors | 48 | 1995 | |
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| 5,409,944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase | 47 | 1993 | |
| 5,604,260 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | 58 | 1993 | |
| 5,552,422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents | 77 | 1995 | |
| 5,510,368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs | 65 | 1995 | |
| 5,604,253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors | 50 | 1995 | |
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| 5,472,943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists | 50 | 1993 | |
| 5,585,348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia | 45 | 1993 | |
| 5,580,876 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists | 49 | 1995 | |
| 6,194,382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists | 27 | 1999 | |
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| 4,719,215 Quaternary derivatives of noroxymorphone which relieve nausea and emesis | 53 | 1986 | |
| 4,861,781 Quaternary derivatives of noroxymorphone which relieve nausea and emesis | 48 | 1987 | |
| 5,102,887 Method for reducing emesis and nausea induced by the administration of an emesis causing agent | 50 | 1990 | |
| 5,972,954 Use of methylnaltrexone and related compounds | 58 | 1997 | |
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| 5,352,683 Method for the treatment of chronic pain | 61 | 1993 | |
| 5,321,012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance | 92 | 1993 | |
| 5,502,058 Method for the treatment of pain | 71 | 1994 | |
| 5,556,838 Inhibiting the development of tolerance to and/or dependence on an addictive substance | 85 | 1994 | |
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| 4,882,335 Method for treating alcohol-drinking response | 53 | 1988 | |
| 5,096,715 Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist | 39 | 1989 | |
| 5,086,058 Method for treating alcoholism with nalmefene | 51 | 1990 | |
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| 5,591,452 Controlled release formulation | 50 | 1994 | |
| 6,326,027 Controlled release formulation | 37 | 1995 | |
| 6,254,887 Controlled release tramadol | 35 | 1996 | |
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| 4,987,136 Method for controlling gastrointestinal dysmotility | 81 | 1986 | |
| 4,769,372 Method of treating patients suffering from chronic pain or chronic cough | 57 | 1986 | |
| 4,785,000 Method of treating patients suffering from chronic pain or chronic cough | 39 | 1987 | |
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| 4,806,558 Diarylacetylenes and their use in treating acne | 34 | 1985 | |
| 4,957,681 Preparation of pharmaceutical mixtures | 65 | 1989 | |
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| 4,451,470 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans | 41 | 1982 | |
| 5,593,994 Prostaglandin synthase inhibitors | 43 | 1994 | |
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| 4,293,539 Controlled release formulations and method of treatment | 74 | 1979 | |
| 5,998,434 Composition for treating pain | 28 | 1998 | |
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| 4,844,909 Controlled release hydromorphone composition | 78 | 1987 | |
| 4,844,910 Spheroids | 33 | 1987 | |
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| 4,760,069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists | 44 | 1985 | |
| 4,889,860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists | 48 | 1987 | |
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| 5,858,017 Urologic irrigation solution and method for inhibition of pain, inflammation and spasm | 82 | 1996 | |
| 5,860,950 Arthroscopic irrigation solution and method for inhibition of pain and inflammation | 66 | 1996 | |
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| 4,861,598 Controlled release bases for pharmaceuticals | 97 | 1986 | |
| 4,970,075 Controlled release bases for pharmaceuticals | 75 | 1989 | |
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| 4,582,835 Analgesic compositions | 63 | 1984 | |
| 4,661,492 Analgesic compositions | 47 | 1985 | |
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| 5,316,759 Agonist-antagonist combination to reduce the use of nicotine and other drugs | 43 | 1992 | |
| 5,574,052 Agonist-antagonist combination to reduce the use of nicotine and other drugs | 87 | 1994 | |
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| 5,130,311 Oxazolopyridine compounds, compositions and use | 29 | 1991 | |
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| 5,256,669 Methods and compositions for treating acute or chronic pain and drug addiction | 39 | 1992 | |
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| 4,873,076 Method of safely providing anesthesia or conscious sedation | 38 | 1989 | |
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| 4,457,933 Prevention of analgesic abuse | 63 | 1981 | |
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| 4,935,428 Treating opiate dependence | 50 | 1988 | |
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| 4,722,928 N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes | 15 | 1985 | |
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| 4,237,140 Analgesic mixture of nalbuphine and acetaminophen | 36 | 1979 | |
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| 5,486,362 Controlled, sustained release delivery system for treating drug dependency | 67 | 1993 | |
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| 5,869,097 Method of therapy comprising an osmotic caplet | 38 | 1992 | |
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| 5,616,601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation | 94 | 1995 | |
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| 5,225,440 Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase | 37 | 1991 | |
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| 5,514,680 Glycine receptor antagonists and the use thereof | 44 | 1993 | |
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| 5,426,112 Growth regulation and related applications of opioid antagonists | 50 | 1993 | |
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| 4,803,208 Opiate agonists and antagonists | 36 | 1985 | |
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| 5,149,538 Misuse-resistive transdermal opioid dosage form | 98 | 1991 | |
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| 5,356,900 Method of treating chronic herpes virus infections using an opiate receptor antagonist | 37 | 1993 | |
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| 4,443,428 Extended action controlled release compositions | 53 | 1982 | |
| 5,376,662 Method of attenuating nerve injury induced pain | 34 | 1993 | |
| 2004/0092,542 Tamper-resistant oral opioid agonist formulations | 11 | 2003 | |
| 2005/0095,291 Tamper-resistant oral opioid agonist formulations | 22 | 2003 | |
| 2005/0181,046 Tamper-resistant oral opioid agonist formulations | 11 | 2003 | |
| 2006/0039,970 Tamper-resistant oral opioid agonist formulations | 8 | 2003 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Jan 6, 2014 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jan 6, 2018 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 6, 2022 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |