Opioid agonist/antagonist combinations

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7749542
APP PUB NO 20080292694A1
SERIAL NO

12220760

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PURDUE PHARMA L.P.STAMFORD, CT463

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colucci, Robert D Newtown, US 21 1992
Kaiko, Robert F Weston, US 47 3236

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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5376662 Method of attenuating nerve injury induced pain 78 1993
2004/0092,542 Tamper-resistant oral opioid agonist formulations 58 2003
2005/0095,291 Tamper-resistant oral opioid agonist formulations 84 2003
2005/0181,046 Tamper-resistant oral opioid agonist formulations 75 2003
2006/0039,970 Tamper-resistant oral opioid agonist formulations 47 2003
 
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4889860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 99 1987
 
The Lynx Project Limited (1)
6310072 Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist 79 1997
 
VIRGINIA COMMONWEALTH UNIVERSITY (4)
5352683 Method for the treatment of chronic pain 132 1993
5321012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance 217 1993
5502058 Method for the treatment of pain 194 1994
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5409944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase 135 1993
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5552422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents 174 1995
5536752 Phenyl heterocycles as COX-2 inhibitors 151 1995
5550142 Phenyl heterocycles as cox-2 inhibitors 155 1995
5510368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs 153 1995
5604253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 142 1995
5639780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 138 1995
 
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5508043 Controlled release matrix for pharmaceuticals 101 1995
5670172 Pharmaceutical spheroid formulation 116 1995
6024982 Immediate release tablet cores of insoluble drugs having sustained-release coating 177 1995
5811126 Controlled release matrix for pharmaceuticals 176 1995
5763452 Pharmaceutical compositions and usages 63 1996
5849240 Method of preparing sustained release pharmaceutical compositions 247 1996
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6143328 Sustained release compositions and a method of preparing pharmaceutical compositions 88 1999
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6210714 Immediate release tablet cores of acetaminophen having sustained-release coating 135 2000
6387404 Immediate release tablet cores of insoluble drugs having sustained-release coating 136 2001
6627635 Method of preventing abuse of opioid dosage forms 185 2001
 
PURDUE PHARMA L.P. (40)
4828836 Controlled release pharmaceutical composition 244 1987
4834985 Controlled release pharmaceutical composition 250 1987
4990341 Controlled release hydromorphone composition 232 1989
5266331 Controlled release oxycodone compositions 330 1991
5273760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 334 1991
5286493 Stabilized controlled release formulations having acrylic polymer coating 328 1992
5549912 Controlled release oxycodone compositions 320 1993
5472712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 320 1993
5478577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level 336 1993
5411745 Powder-layered morphine sulfate formulations 211 1994
5965161 Extruded multi-particulates 270 1994
5639476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 654 1995
5508042 Controlled release oxycodone compositions 361 1995
5968551 Orally administrable opioid formulations having extended duration of effect 344 1995
5958459 Opioid formulations having extended controlled released 229 1995
5656295 Controlled release oxycodone compositions 307 1996
5681585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 193 1996
5672360 Method of treating pain by administering 24 hour oral opioid formulations 309 1996
6143322 Method of treating humans with opioid formulations having extended controlled release 233 1997
5958452 Extruded orally administrable opioid formulations 314 1997
5968547 Method of providing sustained analgesia with buprenorphine 129 1997
6077533 Powder-layered oral dosage forms 98 1998
6228863 Method of preventing abuse of opioid dosage forms 289 1998
* 6277384 Opioid agonist/antagonist combinations 182 1998
6103261 Opioid formulations having extended controlled release 215 1999
6335033 Melt-extrusion multiparticulates 162 1999
6261599 Melt-extruded orally administrable opioid formulations 237 1999
6294195 Orally administrable opioid formulations having extended duration of effect 194 1999
6375957 Opioid agonist/opioid antagonist/acetaminophen combinations 302 2000
6696088 Tamper-resistant oral opioid agonist formulations 243 2001
6716449 Controlled-release compositions containing opioid agonist and antagonist 137 2001
* 6475494 Opioid agonist/antagonist combinations 154 2001
2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone 96 2002
2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist 89 2002
* 6696066 Opioid agonist/antagonist combinations 211 2002
2003/0229,111 Naltrexone hydrochloride compositions 45 2003
2004/0186,121 Tamper-resistant oral opioid agonist formulations 68 2003
* 7172767 Opioid agonist / antagonist combinations 124 2003
2006/0182,801 Sequestered antagonist formulations 85 2006
* 7419686 Opioid agonist/antagonist combinations 78 2006
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (2)
4844909 Controlled release hydromorphone composition 226 1987
4844910 Spheroids 75 1987
 
McGinnis; Carolyn (1)
4608376 Opiate agonists and antagonists 75 1982
 
AMINOTEK SCIENCES, INC. A CORP. OF NEW JERSEY (1)
5256669 Methods and compositions for treating acute or chronic pain and drug addiction 83 1992
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
4464378 Method of administering narcotic antagonists and analgesics and novel dosage forms containing same 237 1981
 
PEPTECH (UK) LIMITED (1)
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The United States of America as represented by the Secretary of the Army (1)
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ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (5)
5472943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists 181 1993
5585348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 106 1993
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6194382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 82 1999
6765010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 69 2002
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (2)
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GENERAL ELECTRIC COMPANY (1)
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RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
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ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (6)
* 5512578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists 135 1994
5767125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 121 1996
6096756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 157 1998
2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS 56 1999
6362194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 70 2000
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5457208 Kappa opioid receptor antagonists 98 1993
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Ortho-McNeil Pharmaceutical, Inc. (1)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
RECRO GAINESVILLE LLC (4)
9132096 Abuse resistant pharmaceutical compositions 2 2014
9486451 Abuse resistant pharmaceutical compositions 0 2015
9452163 Abuse resistant pharmaceutical compositions 0 2015
9713611 Abuse resistant pharmaceutical compositions 0 2016
 
Other [Check patent profile for assignment information] (2)
9993433 Manufacturing of active-free granules and tablets comprising the same 0 2011
9943513 Opioid abuse deterrent dosage forms 0 2016
 
BANNER LIFE SCIENCES LLC (1)
9861629 Opioid abuse deterrent dosage forms 0 2016
 
EURO-CELTIQUE S.A. (2)
9901540 Combination of active loaded granules with additional actives 0 2011
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PURDUE PHARMA L.P. (30)
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* 2010/0056,554 USE OF OPIOID FORMULATIONS IN NEEDLE-LESS DRUG DELIVERY DEVICES 0 2007
9271940 Immediate release pharmaceutical compositions comprising oxycodone and naloxone 0 2010
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8673355 Opioid agonist/antagonist combinations 24 2011
8846090 Matrix for sustained, invariant and independent release of active compounds 26 2012
8822487 Opioid agonist/opioid antagonist/acetaminophen combinations 24 2012
8846091 Matrix for sustained, invariant and independent release of active compounds 25 2013
9084729 Abuse-resistant controlled-release opioid dosage form 7 2013
8969369 Abuse-resistant controlled-release opioid dosage form 25 2013
9056051 Abuse-resistant controlled-release opioid dosage form 9 2014
9205082 Opioid agonist/antagonist combinations 5 2014
9555000 Pharmaceutical preparation containing oxycodone and naloxone 3 2014
9474750 Opioid agonist/opioid antagonist/acetaminophen combinations 3 2014
9655855 Matrix for sustained, invariant and independent release of active compounds 3 2014
8936808 Opioid agonist/opioid antagonist/acetaminophen combinations 9 2014
8932630 Opioid agonist/antagonist combinations 9 2014
9168252 Abuse-resistant controlled-release opioid dosage form 5 2015
9161937 Abuse-resistant controlled-release opioid dosage form 7 2015
9283216 Abuse-resistant controlled-release opioid dosage form 3 2015
9283221 Abuse-resistant controlled-release opioid dosage form 3 2015
9820983 Immediate release pharmaceutical compositions comprising oxycodone and naloxone 0 2016
9358230 Abuse-resistant controlled-release opioid dosage form 3 2016
9345701 Abuse-resistant controlled-release opioid dosage form 3 2016
9763931 Buprenorphine-wafer for drug substitution therapy 0 2016
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9480685 Abuse-resistant controlled-release opioid dosage form 3 2016
9907793 Pharmaceutical preparation containing oxycodone and naloxone 0 2017
 
QRxPHARMA Ltd. (1)
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9370512 Buprenorphine-wafer for drug substitution therapy 1 2015
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8877241 Morphine controlled release system 5 2004
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9694080 Polymer release system 0 2013
8808745 Morphine polymer release system 9 2013
9044402 Abuse-deterrent pharmaceutical compositions for controlled release 7 2014
9707179 Opioid polymer release system 0 2014
9642809 Controlled release pharmaceutical compositions for prolonged effect 0 2014
9375428 Morphine controlled release system 2 2014
9358295 Immediate release composition resistant to abuse by intake of alcohol 4 2015
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* Cited By Examiner

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