US Patent No: 7,749,542

Number of patents in Portfolio can not be more than 2000

Opioid agonist/antagonist combinations

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ALSO PUBLISHED AS: 20080292694
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Abstract

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The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

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Patent Owner(s)

Patent OwnerAddressTotal Patents
PURDUE PHARMA L.P.STAMFORD, CT252

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Colucci, Robert D Newtown, CT 21 554
Kaiko, Robert F Weston, CT 44 946

Cited Art Landscape

Patent Info (Count) # Cites Year
 
PURDUE PHARMA L.P. (39)
4,828,836 Controlled release pharmaceutical composition 146 1987
4,834,985 Controlled release pharmaceutical composition 175 1987
4,990,341 Controlled release hydromorphone composition 98 1989
5,266,331 Controlled release oxycodone compositions 109 1991
5,273,760 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 149 1991
5,286,493 Stabilized controlled release formulations having acrylic polymer coating 147 1992
5,549,912 Controlled release oxycodone compositions 100 1993
5,472,712 Controlled-release formulations coated with aqueous dispersions of ethylcellulose 131 1993
5,478,577 Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level 110 1993
5,411,745 Powder-layered morphine sulfate formulations 74 1994
5,965,161 Extruded multi-particulates 81 1994
5,639,476 Controlled release formulations coated with aqueous dispersions of acrylic polymers 288 1995
5,508,042 Controlled release oxycodone compositions 102 1995
5,968,551 Orally administrable opioid formulations having extended duration of effect 111 1995
5,958,459 Opioid formulations having extended controlled released 70 1995
5,656,295 Controlled release oxycodone compositions 87 1996
5,681,585 Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer 71 1996
5,672,360 Method of treating pain by administering 24 hour oral opioid formulations 112 1996
6,143,322 Method of treating humans with opioid formulations having extended controlled release 79 1997
5,958,452 Extruded orally administrable opioid formulations 102 1997
5,968,547 Method of providing sustained analgesia with buprenorphine 60 1997
6,077,533 Powder-layered oral dosage forms 46 1998
6,228,863 Method of preventing abuse of opioid dosage forms 92 1998
6,277,384 Opioid agonist/antagonist combinations 67 1998
6,103,261 Opioid formulations having extended controlled release 74 1999
6,335,033 Melt-extrusion multiparticulates 52 1999
6,261,599 Melt-extruded orally administrable opioid formulations 84 1999
6,294,195 Orally administrable opioid formulations having extended duration of effect 77 1999
6,375,957 Opioid agonist/opioid antagonist/acetaminophen combinations 84 2000
6,696,088 Tamper-resistant oral opioid agonist formulations 71 2001
6,475,494 Opioid agonist/antagonist combinations 48 2001
2003/0069,263 Pharmaceutical combinations of oxycodone and naloxone 33 2002
2003/0073,714 Opioid agonist formulations with releasable and sequestered antagonist 36 2002
6,696,066 Opioid agonist/antagonist combinations 61 2002
2003/0229,111 Naltrexone hydrochloride compositions 12 2003
2004/0186,121 Tamper-resistant oral opioid agonist formulations 28 2003
7,172,767 Opioid agonist / antagonist combinations 33 2003
2006/0182,801 Sequestered antagonist formulations 28 2006
7,419,686 Opioid agonist/antagonist combinations 17 2006
 
EURO-CELTIQUE S.A. (35)
4,366,310 Controlled release compositions 37 1980
4,940,587 Oral pharmaceutical composition through mucosa 89 1986
4,844,907 Pharmaceutical composition comprising analgesic and anti-inflammatory agent 110 1986
4,834,965 Controlled release pharmaceutical composition 67 1987
4,867,985 Spheroids 72 1988
5,071,646 Pharmaceutical ion exchange resin composition 89 1989
5,091,189 Controlled release dosage forms having a defined water content 33 1991
5,215,758 Controlled release matrix suppository for pharmaceuticals 65 1991
5,324,351 Aqueous dispersions of zein and preparation thereof 75 1992
5,356,467 Controlled release coatings derived from aqueous dispersions of zein 111 1993
5,500,227 Immediate release tablet cores of insoluble drugs having sustained-release coating 116 1993
5,622,722 Spheroid formulation 32 1994
5,508,043 Controlled release matrix for pharmaceuticals 39 1995
5,670,172 Pharmaceutical spheroid formulation 55 1995
6,024,982 Immediate release tablet cores of insoluble drugs having sustained-release coating 71 1995
5,811,126 Controlled release matrix for pharmaceuticals 60 1995
5,763,452 Pharmaceutical compositions and usages 31 1996
5,849,240 Method of preparing sustained release pharmaceutical compositions 76 1996
5,891,471 Pharmaceutical multiparticulates 70 1996
5,601,845 Pharmaceutical spheroid formulation 66 1996
5,843,480 Controlled release diamorphine formulation 55 1996
5,879,705 Sustained release compositions of morphine and a method of preparing pharmaceutical compositions 71 1997
5,908,848 Synergistic composition of codine and ibuprofen to treat arthritis 33 1997
5,942,241 Formulations and methods for providing prolonged local anesthesia 95 1997
6,068,855 Pharmaceutical composition containing a fusible carrier and method for producing the same 51 1997
5,965,163 Substained release compositions and a method of preparing pharmaceutical compositions 80 1997
6,077,532 Pharmaceutical ion exchange resin composition 38 1998
6,306,438 Stabilized sustained release tramadol formulations 47 1998
6,399,096 Pharmaceutical formulation 44 1998
6,143,328 Sustained release compositions and a method of preparing pharmaceutical compositions 37 1999
6,162,467 Sustained release compositions and a method of preparing pharmaceutical compositions 56 1999
6,210,714 Immediate release tablet cores of acetaminophen having sustained-release coating 50 2000
6,387,404 Immediate release tablet cores of insoluble drugs having sustained-release coating 52 2001
6,716,449 Controlled-release compositions containing opioid agonist and antagonist 52 2001
6,627,635 Method of preventing abuse of opioid dosage forms 60 2001
 
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (12)
5,472,943 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other opioid agonists 66 1993
5,585,348 Use of excitatory opioid receptor antagonists to prevent growth factor-induced hyperalgesia 57 1993
5,512,578 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opiod agonists 77 1994
5,624,932 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 37 1995
5,580,876 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 58 1995
5,767,125 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 62 1996
6,096,756 Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 53 1998
6,194,382 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 36 1999
2001/0006,967 METHOD OF SIMULTANEOUSLY ENHANCING ANALGESIC POTENCY AND ATTENUATING ADVERSE SIDE EFFECTS CAUSED BY TRAMADOL AND OTHER BIMODALLY-ACTING OPIOID AGONISTS 12 1999
6,362,194 Method and simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists 22 2000
6,395,705 Method and composition for treating irritable bowel syndrome using low doses of opioid receptor antagonists 32 2001
6,765,010 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects 28 2002
 
MERCK FROSST CANADA LTD. (10)
5,409,944 Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase 58 1993
5,604,260 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 70 1993
5,436,265 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents 70 1993
5,521,213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 82 1994
5,552,422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents 88 1995
5,536,752 Phenyl heterocycles as COX-2 inhibitors 66 1995
5,550,142 Phenyl heterocycles as cox-2 inhibitors 72 1995
5,510,368 N-benzyl-3-indoleacetic acids as antiinflammatory drugs 76 1995
5,604,253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors 60 1995
5,639,780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors 58 1995
 
ALZA CORPORATION (6)
4,200,098 Osmotic system with distribution zone for dispensing beneficial agent 291 1978
4,285,987 Process for manufacturing device with dispersion zone 260 1979
4,573,995 Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine 116 1984
5,236,714 Abusable substance dosage form having reduced abuse potential 71 1988
5,460,826 Morphine therapy 73 1994
5,866,164 Composition and dosage form comprising opioid antagonist 88 1997
 
REGENTS OF THE UNIVERSITY OF MINNESOTA (6)
4,401,672 Non-addictive narcotic antitussive preparation 49 1981
4,730,048 Gut-selective opiates 66 1985
5,352,680 Delta opioid receptor antagonists to block opioid agonist tolerance and dependence 82 1992
5,457,208 Kappa opioid receptor antagonists 60 1993
5,578,725 Delta opioid receptor antagonists 44 1995
5,780,479 Use of opioid antagonists to treat impulse-control disorders 40 1997
 
UNIVERSITY OF CHICAGO, THE (4)
4,719,215 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 68 1986
4,861,781 Quaternary derivatives of noroxymorphone which relieve nausea and emesis 63 1987
5,102,887 Method for reducing emesis and nausea induced by the administration of an emesis causing agent 65 1990
5,972,954 Use of methylnaltrexone and related compounds 75 1997
 
VIRGINIA COMMONWEALTH UNIVERSITY (4)
5,352,683 Method for the treatment of chronic pain 69 1993
5,321,012 Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance 105 1993
5,502,058 Method for the treatment of pain 87 1994
5,556,838 Inhibiting the development of tolerance to and/or dependence on an addictive substance 99 1994
 
CONTRAL CLINICS OY (3)
4,882,335 Method for treating alcohol-drinking response 61 1988
5,096,715 Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist 47 1989
5,086,058 Method for treating alcoholism with nalmefene 59 1990
 
NAPP PHARMACEUTICAL GROUP LIMITED (3)
5,591,452 Controlled release formulation 68 1994
6,326,027 Controlled release formulation 53 1995
6,254,887 Controlled release tramadol 51 1996
 
The Rockefeller University (3)
4,987,136 Method for controlling gastrointestinal dysmotility 97 1986
4,769,372 Method of treating patients suffering from chronic pain or chronic cough 70 1986
4,785,000 Method of treating patients suffering from chronic pain or chronic cough 49 1987
 
BASF AKTIENGESELLSCHAFT (2)
4,806,558 Diarylacetylenes and their use in treating acne 42 1985
4,957,681 Preparation of pharmaceutical mixtures 77 1989
 
E. I. DU PONT DE NEMOURS AND COMPANY (2)
4,451,470 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans 49 1982
5,593,994 Prostaglandin synthase inhibitors 54 1994
 
Eli Lilly and Company (2)
4,293,539 Controlled release formulations and method of treatment 85 1979
5,998,434 Composition for treating pain 36 1998
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (2)
4,844,909 Controlled release hydromorphone composition 92 1987
4,844,910 Spheroids 41 1987
 
NOVA PHARMACEUTICAL CORPORATION (2)
4,760,069 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 52 1985
4,889,860 Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists 56 1987
 
OMEROS CORPORATION (2)
5,858,017 Urologic irrigation solution and method for inhibition of pain, inflammation and spasm 92 1996
5,860,950 Arthroscopic irrigation solution and method for inhibition of pain and inflammation 77 1996
 
PURDUE PHARMA COMPANY, THE (2)
4,861,598 Controlled release bases for pharmaceuticals 112 1986
4,970,075 Controlled release bases for pharmaceuticals 91 1989
 
RECKITT BENCKISER HEALTHCARE (UK) LIMITED (2)
4,582,835 Analgesic compositions 80 1984
4,661,492 Analgesic compositions 56 1985
 
Schaap; Robert J. (2)
5,316,759 Agonist-antagonist combination to reduce the use of nicotine and other drugs 52 1992
5,574,052 Agonist-antagonist combination to reduce the use of nicotine and other drugs 100 1994
 
ADIR ET COMPAGNIE (1)
5,130,311 Oxazolopyridine compounds, compositions and use 38 1991
 
Aminotek Sciences, Inc. (1)
5,256,669 Methods and compositions for treating acute or chronic pain and drug addiction 47 1992
 
BAKER NORTON PHARMACEUTICALS, INC. (1)
4,873,076 Method of safely providing anesthesia or conscious sedation 47 1989
 
BRISTOL-MYERS SQUIBB COMPANY (1)
4,457,933 Prevention of analgesic abuse 78 1981
 
COLMAN PRODUCTS LIMITED (1)
4,935,428 Treating opiate dependence 59 1988
 
DUPONT MERCK PHARMACEUTICAL COMPANY, THE (1)
4,722,928 N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes 17 1985
 
DUPONT PHARMACEUTICALS COMPANY (1)
4,237,140 Analgesic mixture of nalbuphine and acetaminophen 44 1979
 
DYNAGEN, INC. (1)
5,486,362 Controlled, sustained release delivery system for treating drug dependency 78 1993
 
ENCINAL PHARMACEUTICAL INVESTMENTS, LLC (1)
5,869,097 Method of therapy comprising an osmotic caplet 49 1992
 
G. D. Searle & Co. (1)
5,616,601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation 104 1995
 
GENERAL ELECTRIC COMPANY (1)
5,226,331 Apparatus and method for measuring the particle number rate and the velocity distribution of a sprayed stream 36 1991
 
ICN HUNGARY RT. (1)
5,317,022 Pharmaceutical composition and use 47 1992
 
LIFESHIELD SCIENCES LLC (1)
2004/0158,312 Braided endoluminal device having tapered filaments 3 2003
 
McGinnis; Carolyn (1)
4,608,376 Opiate agonists and antagonists 40 1982
 
MERCK FROSST COMPANY (1)
5,474,995 Phenyl heterocycles as cox-2 inhibitors 140 1994
 
MERCK SHARP & DOHME LTD. (1)
5,880,132 Tachykinin antagonist and an opioid analgesic effective at treating pain or nociception 47 1997
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
5,225,440 Attenuation of the opioid withdrawal syndrome by inhibitors of nitric oxide synthase 46 1991
 
OREGON, UNIVERSITY OF (1)
5,514,680 Glycine receptor antagonists and the use thereof 54 1993
 
ORTHO-MCNEIL PHARMACEUTICAL, INC. (1)
5,336,691 Composition comprising a tramadol material and acetaminophen and its use 55 1992
 
PEPTECH LIMITED (1)
5,534,492 Muramyl peptide for the treatment of toxicity 37 1995
 
PUREUE PHARMA L.P. (1)
4,834,984 Controlled release dihydrocodeine composition 87 1987
 
RUTGERS, STATE UNIVERSITY OF NEW JERSEY, THE, OLD QUEEN BUILDING, SOMERSET AND GEORGE STREETS, NEW BRUNSWICK, NJ 08903 (1)
4,806,341 Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration 89 1986
 
SCULLY SCOTT MURPHY & PRESSER, PC (1)
5,426,112 Growth regulation and related applications of opioid antagonists 65 1993
 
SIMON, DAVID L. (1)
6,103,258 Salts and bases of the 17-(Cyclopropylmethyl)-4,5 alpha-epoxy-6-Methylenemorphinan-3,14 diol molecule for optimizing dopamine homeostasis during administration of opioid analgesics 34 1998
 
SLOAN-KETTERING INSTITUTE FOR CANCER RES (1)
4,803,208 Opiate agonists and antagonists 44 1985
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (1)
4,806,543 Method and compositions for reducing neurotoxic injury 66 1986
 
The Lynx Project Limited (1)
6,310,072 Production of analgesic synergy by co-administration of sub-analgesic doses of a MU opioid agonist and a kappa-2 opioid agonist 33 1997
 
THE MCLEAN HOSPITAL CORPORATION (1)
5,075,341 Treatment for cocaine abuse 102 1989
 
The United States of America as represented by the Secretary of the Army (1)
5,834,477 Opiate analgesic formulation with improved safety 32 1994
 
United Biomedical, Inc. (1)
5,633,259 Method for identification of low/non-addictive opioid analgesics and the use of said analgesics for treatment of opioid addiction 39 1995
 
Warner-Lambert Company (1)
5,149,538 Misuse-resistive transdermal opioid dosage form 116 1991
 
YOUNG, JACQUELINE, MS. (1)
5,356,900 Method of treating chronic herpes virus infections using an opiate receptor antagonist 45 1993
 
Other [Check patent profile for assignment information] (7)
4,464,378 Method of administering narcotic antagonists and analgesics and novel dosage forms containing same 125 1981
4,443,428 Extended action controlled release compositions 67 1982
5,376,662 Method of attenuating nerve injury induced pain 42 1993
2004/0092,542 Tamper-resistant oral opioid agonist formulations 22 2003
2005/0095,291 Tamper-resistant oral opioid agonist formulations 32 2003
2005/0181,046 Tamper-resistant oral opioid agonist formulations 23 2003
2006/0039,970 Tamper-resistant oral opioid agonist formulations 15 2003

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
PURDUE PHARMA L.P. (2)
8,105,631 Opioid agonist/antagonist combinations 2 2010
8,673,355 Opioid agonist/antagonist combinations 0 2011
 
EURO-CELTIQUE S.A. (1)
8,518,925 Opioids for the treatment of the chronic obstructive pulmonary disease (COPD) 0 2005

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