US Patent No: 7,754,444

Number of patents in Portfolio can not be more than 2000

Biofunctional magnetic nanoparticles for pathogen detection

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ALSO PUBLISHED AS: 20060292555
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Abstract

This invention provides a method of detecting pathogens comprising the steps of: (a) contacting a sufficient amount of biofunctional magnetic nanoparticles with an appropriate sample for an appropriate period of time to permit the formation of complexes between the pathogens in the sample and the nanoparticles; (b) using a magnetic field to aggregate said complexes; and (c) detecting said complexes. The method may further comprise the additional step of removing said complexes. The biofunctional magnetic nanoparticles are preferably a conjugate of vancomycin and FePt. The pathogens may be bacteria or viruses, and the sample may be a solid, liquid, or gas. Detection may involve conventional fluorescence assay, enzyme-linked immunosorbent assay (ELISA), optical microscope, electron microscope, or a combination thereof. The sensitivity of detection for the method is at least as low as 10 colony forming units (cfu) of the pathogens in one milliliter of solution within one hour.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGYHONG KONG224
THE UNIVERSITY OF HONG KONGHONG KONG101

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gu, Hongwei Kowloon, HK 5 0
Ho, Pak Leung Kwai Chung, HK 2 0
Xu, Bing Tempe, AZ 66 77

Cited Art

Patent Info (Count) # Cites Year
 
HGST NETHERLANDS B.V. (2)
6,254,662 Chemical synthesis of monodisperse and magnetic alloy nanocrystal containing thin films 40 1999
6,302,940 Chemical synthesis of monodisperse and magnetic alloy nanocrystal containing thin films 20 2001
 
DADE BEHRING MARBURG GMBH (1)
5,279,936 Method of separation employing magnetic particles and second medium 41 1989
 
GORDON, DAVID, SKOKIE, ILLINOIS (1)
4,590,922 Use of ferromagnetic, paramagnetic and diamagnetic particles in the treatment of infectious diseases 28 1983
 
INTERNATIONAL BUSINESS MACHINES CORPORATION (1)
6,262,129 Method for producing nanoparticles of transition metals 107 1998
 
PURDUE RESEARCH FOUNDATION (1)
7,186,398 Fe/Au nanoparticles and methods 7 2003
 
SINVENT VENTURES A S (1)
2006/0188,876 Binding a target substance 5 2003
 
VERIDEX, LLC (1)
6,620,627 Increased separation efficiency via controlled aggregation of magnetic nanoparticles 13 2000

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