Biocatalytic manufacturing of (meth) acrylylcholine or 2-(N, N-dimethylamino) ethyl (meth) acrylate
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United States of America Patent
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Jul 13, 2010
Grant Date -
Oct 11, 2007
app pub date -
Mar 9, 2005
filing date -
Mar 19, 2004
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Abstract
A biocatalytic method for the synthesis of 2-(N,N-dimethyl amino)ethanol and/or choline esters of acrylic acid and/or methacrylic acid comprising reacting 2-(N,N-dimethylamino)ethanol and/or choline with acrylyl-CoA and/or methacrylyl-coA in the presence of a biocatalyst with choline acetyltransferase activity. The acrylyl-CoA and/or the methacrylyl CoA is formed by the reaction of acrylate and/or methacrylate with coenzyme A in the presence of ATP and a biocatalyst with S-acetyl coenzyme A synthetase activity.
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