OX40R binding agents
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United States of America Patent
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Jul 20, 2010
Grant Date -
Jan 11, 2007
app pub date -
Apr 2, 2003
filing date -
Apr 3, 2002
priority date (Note) -
Expired
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Abstract
The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with natural OX40L for blocking OX40R-mediated cell signaling in the prophylaxis and/or treatment of diseases related to activated T cells.
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