SLO2 and SLO4, novel potassium channel proteins from human brain
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United States of America Patent
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Aug 3, 2010
Grant Date -
Jan 15, 2009
app pub date -
Jul 22, 2008
filing date -
Nov 15, 2000
priority date (Note) -
Expired
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Abstract
The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.
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