Compositions and methods for inhibiting expression of anti-apoptotic genes
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United States of America Patent
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Aug 3, 2010
Grant Date -
Aug 11, 2005
app pub date -
Sep 15, 2004
filing date -
Jan 9, 2001
priority date (Note) -
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Abstract
The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of an apoptotic gene, such as a Bcl gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell.
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