MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting

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United States of America Patent

PATENT NO 7769423
APP PUB NO 20070197904A1
SERIAL NO

11648148

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Abstract

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Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
DUKE UNIVERSITY2812 ERWIN ROAD SUITE 306 DURHAM NC 27710

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dewhirst, Mark W Durham, US 40 404
Ponce, Ana M Durham, US 1 30
Viglianti, Benjamin L Durham, US 4 42

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