Gastric retention controlled drug delivery system
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United States of America Patent
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Aug 17, 2010
Grant Date -
Sep 16, 2004
app pub date -
Jul 4, 2002
filing date -
Jul 4, 2001
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention provides a gastric retention controlled drug delivery system comprising: (a) a controlled release core comprising a drug, a highly swellable polymer and a gas generating agent, said core being capable of swelling and achieving floatation rapidly while maintaining its physical integrity in gastrointestinal fluids for prolonged periods, and (b) a rapidly releasing coat composition comprising the same drug as in the core and pharmaceutically acceptable excipients, wherein the coating composition surrounds the core such that the system provides a biphasic release of the drug in gastrointestinal fluids.
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