-bisphosphonate derivatives

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United States of America Patent

PATENT NO 7780953
APP PUB NO 20040253181A1
SERIAL NO

10739400

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: X-L-CH(PO.sub.3H.sub.2).sub.2 (I) in which: L represents an organic group connecting the X group to the gem-bisphosphonate group --CH(PO.sub.3H.sub.2).sub.2; X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates, also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).

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Patent Owner(s)

Patent OwnerAddress
GUERBETFRANCE VILLEPINTE VILLEURBANNE RHONE

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Corot, Claire Lyons, FR 16 108
Port, Marc Deuil la Barre, FR 33 226
Raynal, Isabelle Saint Maur des Fosses, FR 3 35
Rousseaux, Olivier Senlis, FR 24 130

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