Method for extending the dynamic detection range of assay devices
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United States of America Patent
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Aug 24, 2010
Grant Date -
May 26, 2005
app pub date -
Nov 21, 2003
filing date -
Nov 21, 2003
priority date (Note) -
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Abstract
A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a detection zone and compensation zone within which are immobilized capture reagents. The present inventor has discovered that the presence of a compensation zone may enable the detection of an analyte over extended concentration ranges. In particular, the compensation zone facilitates the binding of probes that would otherwise bind within the interior of assay device or that would exhibit “self-quenching”.
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