Method and apparatus for automated image analysis of biological specimens
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United States of America Patent
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Aug 24, 2010
Grant Date -
Mar 5, 2009
app pub date -
Aug 29, 2008
filing date -
Nov 30, 1995
priority date (Note) -
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Abstract
A method including acquiring images of medical slides at a plurality of different focus positions, determining a position which produces a maximum value of pixel values relative to a pixel value mean, wherein said determining comprises using a pixel value mean as a coarse estimate of coarse focus position, and subsequently refining said coarse focus position to find a fine focus position, and wherein said refining comprises fitting to a polynomial, and using a specified portion of the polynomial as a fine estimate of focus position, and producing a focus control signal that is related to said maximum value to control a focus position.
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