Chemically modified small molecules
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United States of America Patent
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Aug 31, 2010
Grant Date -
Jun 23, 2005
app pub date -
Dec 16, 2004
filing date -
Dec 16, 2003
priority date (Note) -
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Abstract
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.
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