Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease
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United States of America Patent
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Aug 31, 2010
Grant Date -
Nov 8, 2007
app pub date -
Apr 30, 2007
filing date -
May 3, 2006
priority date (Note) -
Expired
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Abstract
The present invention provides compounds having a chelating moiety and an oligonucleotide sequence wherein the oligonucleotide includes one or more modified nucleobases, such as hydroxynucleobases. The disclosed compounds are suitable for antisense therapy. The chelating moiety can be complexed to an ion of a lanthanide metal. These compounds are efficient translation inhibitors of nucleic acids and have increased binding affinity for target nucleic acids. The invention also includes compositions and methods of using these compositions as antisense therapy.
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