Radio-opaque compounds, compositions containing same and methods of their synthesis and use
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United States of America Patent
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Sep 7, 2010
Grant Date -
Feb 17, 2005
app pub date -
Aug 9, 2004
filing date -
Aug 11, 2003
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Abstract
Radio-opaque biodegradable compositions are formed by modifying terminal groups of synthetic and natural biodegradable polymers such as polylactones with iodinated moieties. The biodegradable property of the compositions renders them suitable for use in medical field such as drug delivery, imaging. Compounds disclosed in this invention exist as neat liquid. Certain compositions disclosed in this invention form hydrophobic iodine rich domains when dissolved in water, such domains provide better contrasting properties as well as ability to dissolve hydrophobic bioactive drugs. Certain iodinated moieties disclosed in the invention are capable of cross linking natural proteins in situ in presence of suitable catalysts and co-catalysts.
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