Antisense oligonucleotides with increased RNase sensitivity

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United States of America Patent

PATENT NO 7790877
APP PUB NO 20030119016A1
SERIAL NO

10142566

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Abstract

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Combinatorial libraries comprise first oligonucleotide analogs and second oligonucleotide analogs which are coupled together to form antisense molecules capable of binding target polynucleotides and activating an RNase, and ribozymes capable of cleaving polynucleotides.

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Patent Owner(s)

Patent OwnerAddress
GEN-PROBE INCORPORATED9620 CHESAPEAKE DRIVE #210 SAN DIEGO CALIFORNIA 92123 U S A
BIOLUCENT LLC250 CAMPUS DRIVE MARLBOROUGH MA 01752
CYTYC CORPORATION250 CAMPUS DRIVE MARLBOROUGH MA 01752
HOLOGIC INC250 CAMPUS DRIVE MARLBOROUGH MA 01752
SUROS SURGICAL SYSTEMS INC6100 TECHNOLOGY CENTER DRIVE NORTHWEST TECHNOLOGY CENTER INDIANAPOLIS IN 46278
THIRD WAVE TECHNOLOGIES INC250 CAMPUS DRIVE MARLBOROUGH MA 01752
CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP250 CAMPUS DRIVE MARLBOROUGH MA 01752

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnold, Lyle J San Diego, US 19 172
Brown, Bob D San Diego, US 76 494
Riley, Timothy A San Diego, US 61 827

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